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PPP1CB [cytosol]
Stable Identifier
R-HSA-163405
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PP1CB, Serine/threonine protein phosphatase PP1-beta catalytic subunit , PP-1B
Icon
Locations in the PathwayBrowser
Expand all
Circadian Clock (Homo sapiens)
CSNK1E,CSNK1D phosphorylate CRY and PER proteins (Homo sapiens)
PP1 catalytic subunit [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Signaling by MRAS-complex mutants (Homo sapiens)
Gain-of-function MRAS complexes activate RAF signaling (Homo sapiens)
Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
mutant MRAS:SHOC2:PP1 complexes [plasma membrane] (Homo sapiens)
S-GCC MRAS mutants:GTP:SHOC2:PP1 [plasma membrane] (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
S-GCC MRAS:GTP:SHOC2 S2G:PP1 [plasma membrane] (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
SHOC2 M1731 mutant abolishes MRAS complex function (Homo sapiens)
SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
SHOC2 M173I:MRAS:PP1 [plasma membrane] (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
Respiratory syncytial virus (RSV) genome replication, transcription and translation (Homo sapiens)
Maturation of hRSV A proteins (Homo sapiens)
P binds to PPP1C complex (Homo sapiens)
P:PP1 [cytosol] (Homo sapiens)
PP1 [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
PP1 [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
P:PP1 dephosphorylates M2-1 (Homo sapiens)
P:PP1 [cytosol] (Homo sapiens)
PP1 [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Triglyceride metabolism (Homo sapiens)
Triglyceride catabolism (Homo sapiens)
phosphorylated perilipin + H2O -> perilipin + orthophosphate (Homo sapiens)
PP1 catalytic subunit [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAF activation (Homo sapiens)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
S-GCC MRAS:GTP:SHOC2:PP1 [plasma membrane] (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate ROCKs (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
Myosin phosphatase inactivation by ROCK (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
p-T696,S852-MYPT1-Myosin Phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
RHO GTPases activate CIT (Homo sapiens)
Activated CIT phosphorylates MRLCs (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
RHO GTPases activate PAKs (Homo sapiens)
MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
PAK1 phosphorylates myosin phosphatase (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
p-T696-PPP1R12A-Myosin phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
RHO GTPases activate PKNs (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
p-T38-PPP1R14A binds MLCP (Homo sapiens)
MLCP:p-T38-PPP1R14A [cytosol] (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
PP1 dephosphorylates TGFBR1 (Homo sapiens)
GADD34:PP1 [cytosol] (Homo sapiens)
PP1 catalytic subunit [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:ZFYVE9 [early endosome membrane] (Homo sapiens)
GADD34:PP1 [cytosol] (Homo sapiens)
PP1 catalytic subunit [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR (Homo sapiens)
GADD34:PP1 [cytosol] (Homo sapiens)
PP1 catalytic subunit [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:ZFYVE9 [early endosome membrane] (Homo sapiens)
GADD34:PP1 [cytosol] (Homo sapiens)
PP1 catalytic subunit [cytosol] (Homo sapiens)
PPP1CB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62140 PPP1CB
Gene Names
PPP1CB
Chain
initiator methionine:, chain:2-327
Reference Genes
BioGPS Gene:5500 PPP1CB
COSMIC (genes):PPP1CB PPP1CB
CTD Gene:5500 PPP1CB
dbSNP Gene:5500 PPP1CB
ENSEMBL:ENSG00000213639 PPP1CB
HGNC:9282 PPP1CB
KEGG:hsa:5500 PPP1CB
Monarch:5500 PPP1CB
NCBI Gene:5500 PPP1CB
OMIM:600590 PPP1CB
UCSC:P62140 PPP1CB
Reference Transcript
RefSeq:NM_206876.1 PPP1CB
RefSeq:NM_002709.2 PPP1CB
Other Identifiers
11725614_s_at
11725615_a_at
11725616_at
11746720_a_at
11757308_s_at
16878522
16878541
201407_PM_s_at
201407_s_at
201408_PM_at
201408_at
201409_PM_s_at
201409_s_at
2475210
2475211
2475212
2475213
2475214
2475216
2475226
2475227
2475228
2475232
2475233
2475234
2475235
2475237
2475241
2475242
2475244
2475245
2475246
2475247
2475248
2475249
2475250
2475251
5500
68234_r_at
78737_at
8041122
A_14_P125869
A_24_P396720
A_24_P405298
GE60066
GO:0000165
GO:0000781
GO:0003824
GO:0004721
GO:0004722
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0005925
GO:0005975
GO:0005977
GO:0006091
GO:0006470
GO:0016787
GO:0016791
GO:0017018
GO:0019901
GO:0030155
GO:0032922
GO:0042752
GO:0043153
GO:0043226
GO:0046872
GO:0048511
GO:0050115
GO:0051301
GO:0070062
GO:0072357
GO:0140096
HMNXSV003012482
Hs.21537.0.S2_3p_a_at
Hs.21537.0.S4_3p_s_at
ILMN_2405018
ILMN_2405023
PH_hs_0001870
TC02004955.hg
X80910_at
g4506004_3p_a_at
Participates
as a component of
PP1 [cytosol] (Homo sapiens)
p-T696,S852-MYPT1-Myosin Phosphatase [cytosol] (Homo sapiens)
p-T696-PPP1R12A-Myosin phosphatase [cytosol] (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
as a member of
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PP1 catalytic subunit [cytosol] (Homo sapiens)
Other forms of this molecule
PPP1CB P49R [cytosol]
PPP1CB A56P [cytosol]
PPP1CB [nucleoplasm]
Inferred To
PPP1CB [cytosol]
(Bos taurus)
PPP1CB [cytosol]
(Caenorhabditis elegans)
PPP1CB [cytosol]
(Canis familiaris)
PPP1CB [cytosol]
(Drosophila melanogaster)
PPP1CB [cytosol]
(Gallus gallus)
PPP1CB [cytosol]
(Mus musculus)
PPP1CB [cytosol]
(Rattus norvegicus)
PPP1CB [cytosol]
(Sus scrofa)
PPP1CB [cytosol]
(Xenopus tropicalis)
ppp1cbl [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_002700.1
,
NP_996759.1
ENSEMBL
ENST00000703173
,
ENSP00000398839
,
ENSP00000296122
,
ENSP00000515219
,
ENST00000395366
,
ENSP00000378769
,
ENSP00000414918
,
ENST00000441461
,
ENST00000296122
,
ENST00000420282
OpenTargets
ENSG00000213639
IntEnz
3.1.3.53
HPA
ENSG00000213639-PPP1CB
PRO
P62140
Pharos - Targets
P62140
GlyGen
P62140
Orphanet
PPP1CB
HMDB Protein
HMDBP01775
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8WUF5 PPP1R13L
1
PPP1R13L [nucleoplasm]
(R-HSA-6799738)
0.902
8
UniProt:Q12972 PPP1R8
1
PPP1R8 [nucleoplasm]
(R-HSA-9770253)
0.816
6
UniProt:Q9UQK1 PPP1R3C
2
K48polyUb-PPP1R3C [cytosol]
(R-HSA-3781005)
PPP1R3C [cytosol]
(R-HSA-3777102)
0.782
9
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.725
4
UniProt:Q5UIP0 RIF1
1
RIF1 [nucleoplasm]
(R-HSA-480742)
0.676
4
UniProt:Q6UXN9 WDR82
1
WDR82 [nucleoplasm]
(R-HSA-9821474)
0.671
4
UniProt:P38398 BRCA1
20
polySUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
monoSUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
BRCA1 M1411T [nucleoplasm]
(R-HSA-9702140)
BRCA1 M1400V [nucleoplasm]
(R-HSA-9701202)
BRCA1 L1407P [nucleoplasm]
(R-HSA-9702135)
BRCA1 Y777* [nucleoplasm]
(R-HSA-9702765)
BRCA1 S1009* [nucleoplasm]
(R-HSA-9702755)
BRCA1 P724Lfs*12 [nucleoplasm]
(R-HSA-9703778)
BRCA1 S451* [nucleoplasm]
(R-HSA-9702754)
BRCA1 S864* [nucleoplasm]
(R-HSA-9702752)
BRCA1 P897Kfs*5 [nucleoplasm]
(R-HSA-9703782)
BRCA1 N555Kfs*17 [nucleoplasm]
(R-HSA-9703781)
BRCA1 Y1127Sfs*6 [nucleoplasm]
(R-HSA-9703780)
BRCA1 S886Cfs*16 [nucleoplasm]
(R-HSA-9703802)
BRCA1 V83Cfs*2 [nucleoplasm]
(R-HSA-9703800)
BRCA1 T464Pfs*11 [nucleoplasm]
(R-HSA-9703807)
BRCA1 G813Dfs*2 [nucleoplasm]
(R-HSA-9703549)
BRCA1 V340Gfs*6 [nucleoplasm]
(R-HSA-9703804)
BRCA1 Y655* [nucleoplasm]
(R-HSA-9702769)
BRCA1 W372* [nucleoplasm]
(R-HSA-9702768)
0.581
3
UniProt:Q9BZF9 UACA
1
UACA [cytosol]
(R-HSA-6804636)
0.569
3
UniProt:Q9NX63 CHCHD3
3
CHCHD3 [mitochondrial intermembrane space]
(R-HSA-8874907)
4xHC-CHCHD3 [mitochondrial intermembrane space]
(R-HSA-8874910)
CHCHD3 (MIC19) [mitochondrial inner membrane]
(R-HSA-8949583)
0.556
3
UniProt:P36873 PPP1CC
1
PPP1CC [cytosol]
(R-HSA-163443)
0.527
4
UniProt:Q8NI77 KIF18A
1
KIF18A [cytosol]
(R-HSA-376239)
0.508
2
UniProt:O08785 Clock
2
p-S-Clock [nucleoplasm]
(R-MMU-508670)
Clock [cytosol]
(R-MMU-508720)
0.508
2
UniProt:P19388 POLR2E
2
POLR2E [cytosol]
(R-HSA-1964438)
POLR2E [nucleoplasm]
(R-HSA-83713)
0.508
2
UniProt:O60828 PQBP1
1
PQBP1 [nucleoplasm]
(R-HSA-8867889)
0.508
2
UniProt:Q9UBK9 UXT
1
UXT [nucleoplasm]
(R-HSA-9007484)
0.508
2
UniProt:Q9Y2W2 WBP11
1
WBP11 [nucleoplasm]
(R-HSA-8867887)
0.508
2
UniProt:P19338 NCL
3
NCL [plasma membrane]
(R-HSA-9836466)
NCL [macropinosome membrane]
(R-HSA-9837666)
NCL [nucleoplasm]
(R-HSA-6791213)
0.463
2
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