Reactome | CAV1 [lipid droplet]

CAV1 [lipid droplet]

Stable Identifier

R-HSA-163510

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lipid droplet

Synonyms

caveolin-1

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External Reference Information

External Reference

UniProt:Q03135 CAV1

Gene Names

CAV1, CAV

Chain

initiator methionine:1, chain:2-178

Reference Genes

BioGPS Gene:857 CAV1

COSMIC (genes):CAV1 CAV1

CTD Gene:857 CAV1

dbSNP Gene:857 CAV1

ENSEMBL:ENSG00000105974 CAV1

HGNC:1527 CAV1

KEGG Gene (Homo sapiens):857 CAV1

Monarch:857 CAV1

NCBI Gene:857 CAV1

OMIM:601047 CAV1

UCSC:Q03135 CAV1

Reference Transcript

RefSeq:NM_001753.4 CAV1

Other Identifiers

0003140039

11715584_a_at

11745715_a_at

11745716_s_at

11757013_x_at

17050578

203065_s_at

212097_at

3020303

3020304

3020305

3020306

3020307

3020308

3020309

3020310

3020311

3020320

3020321

3020322

3020323

3020324

36119_at

3791

49326

8135594

857

A0A024R757

A_24_P12626

AAD23745

AAD34722

AAH09685

AAH82246

AAP35807

AAX07830

AB451284

AB451416

AF095591

AF095592

AF095593

AF125348

AJ133269

AK290871

AY762103

BAF83560

BAG70098

BAG70230

BC009685

BC082246

BT007143

C9JKI3

CAA79476

CAB003791

CAB63654

CAV1

CAV1-201

CAV1-202

CAV1-203

CAV1-205

CAV1-209

CCDS55156

CCDS5767

CH236947

CH471070

E9PCT5

EAL24360

EAW83503

EAW83504

EAW83505

ENSG00000105974

ENSP00000339191

ENSP00000377110

ENSP00000377111

ENSP00000384348

ENSP00000479447

ENST00000341049

ENST00000341049.6

ENST00000393467

ENST00000393467.1

ENST00000393468

ENST00000393468.1

ENST00000405348

ENST00000405348.5

ENST00000614113

ENST00000614113.4

EntrezGene:857

EntrezGene:CAV1

F8WDM7

g4580417_3p_s_at

GE54670

GO:0000122

GO:0000139

GO:0000188

GO:0001525

GO:0001570

GO:0001666

GO:0001937

GO:0001960

GO:0002026

GO:0002080

GO:0002376

GO:0002931

GO:0003013

GO:0003057

GO:0003674

GO:0005102

GO:0005113

GO:0005198

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005768

GO:0005783

GO:0005789

GO:0005794

GO:0005811

GO:0005886

GO:0005887

GO:0005901

GO:0005925

GO:0005929

GO:0005938

GO:0006464

GO:0006629

GO:0006641

GO:0006810

GO:0006816

GO:0006874

GO:0006940

GO:0006950

GO:0007009

GO:0007155

GO:0007165

GO:0007267

GO:0007519

GO:0007595

GO:0008104

GO:0008150

GO:0008219

GO:0008283

GO:0008285

GO:0008289

GO:0009056

GO:0009058

GO:0009617

GO:0009968

GO:0010524

GO:0010608

GO:0010628

GO:0010952

GO:0015485

GO:0016020

GO:0016021

GO:0016032

GO:0016050

GO:0016192

GO:0016504

GO:0019065

GO:0019217

GO:0019899

GO:0019901

GO:0019915

GO:0022607

GO:0030154

GO:0030193

GO:0030234

GO:0030301

GO:0030335

GO:0030512

GO:0030666

GO:0030674

GO:0030857

GO:0030879

GO:0031295

GO:0031397

GO:0031398

GO:0031410

GO:0031623

GO:0031901

GO:0032091

GO:0032092

GO:0032507

GO:0032570

GO:0032991

GO:0033137

GO:0033138

GO:0033484

GO:0034141

GO:0034330

GO:0034641

GO:0040011

GO:0042310

GO:0042383

GO:0042532

GO:0042592

GO:0042632

GO:0042802

GO:0043085

GO:0043226

GO:0043407

GO:0043409

GO:0043627

GO:0044281

GO:0044325

GO:0044403

GO:0044860

GO:0044877

GO:0045019

GO:0045121

GO:0045907

GO:0046426

GO:0046982

GO:0048365

GO:0048471

GO:0048550

GO:0048646

GO:0048856

GO:0048870

GO:0050900

GO:0050998

GO:0050999

GO:0051001

GO:0051092

GO:0051117

GO:0051259

GO:0051260

GO:0051480

GO:0051592

GO:0051899

GO:0052547

GO:0055074

GO:0055085

GO:0060056

GO:0060090

GO:0060355

GO:0060546

GO:0061024

GO:0061099

GO:0065003

GO:0070320

GO:0070836

GO:0071360

GO:0071375

GO:0071455

GO:0071560

GO:0072584

GO:0086091

GO:0086098

GO:0090090

GO:0090263

GO:0097190

GO:0098903

GO:0098909

GO:0098911

GO:0120162

GO:1900027

GO:1900085

GO:1901380

GO:1901844

GO:1903071

GO:1903361

GO:1903598

GO:1903609

GO:1904886

GO:2000286

GO:2000535

GO:2000811

GO:2001238

GO:2001244

HGNC:1527

HPA049326

Hs.74034.1.S1_3p_at

ILMN_1687583

ILMN_2149226

IPR001612

IPR015504

IPR018361

MIM:601047

MIM:606721

MIM:612526

MIM:615343

NM_001172895

NM_001172896

NM_001172897

NM_001753

NP_001166366

NP_001166367

NP_001166368

NP_001744

PF01146

PH_hs_0004233

Q2TNI1

TC07003339.hg

UPI0000071F3D

UPI00001270ED

Z18951

Z18951_at

Participant Of

input

eNOS associates with Caveolin-1

output

Caveolin-1 dissociates from eNOS:CaM:HSP90 complex

This entity regulates

Positively

perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP

Other forms of this molecule

CAV1 [plasma membrane]

CAV1 [early endosome membrane]

CAV1 [Golgi membrane]

CAV1 [endocytic vesicle membrane]

Inferred To

CAV1 [lipid droplet] (Bos taurus)

CAV1 [lipid droplet] (Caenorhabditis elegans)

CAV1 [lipid droplet] (Canis familiaris)

CAV1 [lipid droplet] (Mus musculus)

CAV1 [lipid droplet] (Rattus norvegicus)

CAV1 [lipid droplet] (Xenopus tropicalis)

Homologues of CAV1 [lipid droplet] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001744.2

OpenTargets

ENSG00000105974

GeneCards

Q03135

PRO

Q03135

Orphanet

17896

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.752	6
UniProt:P18031 PTPN1	1	PTPN1 [cytosol] (R-HSA-210625)	0.697	5
UniProt:Q969G5 CAVN3			0.649	11
UniProt:P48995 TRPC1	2	TRPC1 [plasma membrane] (R-HSA-2089937) TRPC1 [plasma membrane] (R-HSA-612168)	0.633	7
UniProt:Q16881 TXNRD1	1	TXNRD1 [cytosol] (R-HSA-73531)	0.632	4
UniProt:P41134 ID1	1	ID1 [nucleoplasm] (R-HSA-2534101)	0.602	6
UniProt:O95810 CAVN2			0.602	6
UniProt:P20936 RASA1	1	RASA1 [cytosol] (R-HSA-186833)	0.59	2
UniProt:P51636 CAV2	2	CAV2 [Golgi membrane] (R-HSA-9021032) CAV2 [plasma membrane] (R-HSA-9021035)	0.564	2
UniProt:O75581 LRP6	8	p-S1490-LRP6 [plasma membrane] (R-HSA-206156) p-T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-205884) LRP6 [early endosome membrane] (R-HSA-5368481) LRP6 [plasma membrane] (R-HSA-206252) p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-1458895) p-LRP6 [early endosome membrane] (R-HSA-5368496) p-2S,S1490,2T-LRP6 [plasma membrane] (R-HSA-1458894) LRP6N [extracellular region] (R-HSA-5334021)	0.556	3
UniProt:P52735-1 VAV2			0.544	3
UniProt:Q03160	1	GRB7 [cytosol] (R-MMU-204819)	0.532	3
UniProt:P19174 PLCG1	6	p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.525	2
UniProt:O00194 RAB27B	5	GGC-RAB27B [cytosol] (R-HSA-8873786) GGC-RAB27B [melanosome membrane] (R-HSA-8877280) RAB27B [cytosol] (R-HSA-8873706) RAB27B [plasma membrane] (R-HSA-8862952) RAB27B [platelet dense granule membrane] (R-HSA-8862955)	0.524	2
UniProt:P0DOE7 MATRX			0.524	2
UniProt:P01112 HRAS	17	HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS [plasma membrane] (R-HSA-62717) HRAS Q61L [plasma membrane] (R-HSA-6802452) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS G12C [plasma membrane] (R-HSA-9656561) S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912)	0.508	2
UniProt:P10586 PTPRF	1	PTPRF [plasma membrane] (R-HSA-6786486)	0.499	2
UniProt:Q06124 PTPN11	4	PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y546-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [cytosol] (R-HSA-162563) p-Y546,Y584-PTPN11 [cytosol] (R-HSA-162573)	0.499	2
UniProt:Q6NZI2 CAVIN1	1	PTRF [nucleoplasm] (R-HSA-74981)	0.499	8
UniProt:P60484 PTEN	41	PTEN [nucleoplasm] (R-HSA-5690148) K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379) PTEN C124Y [cytosol] (R-HSA-2317464) PTEN R130P [cytosol] (R-HSA-2317432) PTEN C124F [cytosol] (R-HSA-2317461) PTEN G129V [cytosol] (R-HSA-2318503) PTEN S170I [cytosol] (R-HSA-2318455) PTEN S170G [cytosol] (R-HSA-2318465) PTEN R233* [cytosol] (R-HSA-2318573) PTEN R335* [cytosol] (R-HSA-2318568) PTEN R130* [cytosol] (R-HSA-2318571) p-Y336-PTEN [cytosol] (R-HSA-8847980) PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol] (R-HSA-8948841) RibC-E40,E150,D326-PTEN [cytosol] (R-HSA-8948798) p-3S,2T-PTEN [cytosol] (R-HSA-8850936) PTEN [cytosol] (R-HSA-199420) PTEN [nucleoplasm] (R-HSA-6807273) MonoUb-K13,K289-PTEN [nucleoplasm] (R-HSA-6807264) MonoUb-K13,K289-PTEN [cytosol] (R-HSA-6807247) K48polyUb-K289-PTEN [cytosol] (R-HSA-8948777) PolyUb-PTEN [cytosol] (R-HSA-6807280) K27polyUb-PTEN [cytosol] (R-HSA-8851009)	0.499	2
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.499	2
UniProt:P29350 PTPN6	5	PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938) PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [tertiary granule lumen] (R-HSA-6800952)	0.499	2
UniProt:P52735 VAV2	2	p-Y172-VAV2 [cytosol] (R-HSA-442307) VAV2 [cytosol] (R-HSA-195012)	0.499	2
UniProt:P22307 SCP2	4	SCP2(1-424) [peroxisomal matrix] (R-HSA-9033486) SCP2(425-547) [peroxisomal matrix] (R-HSA-9033522) SCP2 [cytosol] (R-HSA-9033130) SCP2 [peroxisomal matrix] (R-HSA-2046067)	0.482	3
UniProt:Q07820 MCL1	1	MCL1 [cytosol] (R-HSA-5661490)	0.463	3
UniProt:O70239 AXIN1			0.463	5
UniProt:O15118 NPC1	1	NPC1 [lysosomal membrane] (R-HSA-5216153)	0.463	3
UniProt:P25445 FAS	1	FAS [plasma membrane] (R-HSA-66248)	0.463	3
UniProt:P55957 BID	4	BID(62-195) [cytosol] (R-HSA-139953) BID(1-195) [cytosol] (R-HSA-50825) MYS-BID(62-195) [mitochondrial outer membrane] (R-HSA-114266) MYS-BID(62-195) [cytosol] (R-HSA-141373)	0.463	3
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848)	0.463	3