Reactome | CAV1 [lipid droplet]

CAV1 [lipid droplet]

Stable Identifier

R-HSA-163510

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lipid droplet

Synonyms

caveolin-1

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q03135 CAV1

Gene Names

CAV1, CAV

Chain

initiator methionine:1, initiator methionine:, chain:2-178

Reference Genes

BioGPS Gene:857 CAV1

COSMIC (genes):CAV1 CAV1

CTD Gene:857 CAV1

dbSNP Gene:857 CAV1

ENSEMBL:ENSG00000105974 CAV1

ENSEMBL:ENSG00000105974.13 CAV1

HGNC:1527 CAV1

KEGG Gene (Homo sapiens):857 CAV1

Monarch:857 CAV1

NCBI Gene:857 CAV1

OMIM:601047 CAV1

UCSC:Q03135 CAV1

Reference Transcript

RefSeq:NM_001753.4 CAV1

Other Identifiers

11715584_a_at

11745715_a_at

11745716_s_at

11757013_x_at

17050578

203065_PM_s_at

203065_s_at

212097_PM_at

212097_at

3020304

3020305

3020306

3020307

3020308

3020309

3020310

3020311

3020320

3020321

3020322

3020323

3020324

36119_at

8135594

857

A_24_P12626

GE54670

GO:0000122

GO:0000139

GO:0000165

GO:0001525

GO:0001570

GO:0001666

GO:0001935

GO:0001937

GO:0001960

GO:0002026

GO:0002067

GO:0002080

GO:0002095

GO:0002376

GO:0002931

GO:0003012

GO:0003013

GO:0003057

GO:0005102

GO:0005113

GO:0005515

GO:0005768

GO:0005783

GO:0005789

GO:0005794

GO:0005811

GO:0005886

GO:0005901

GO:0005925

GO:0005929

GO:0005938

GO:0006351

GO:0006355

GO:0006629

GO:0006641

GO:0006809

GO:0006816

GO:0006874

GO:0006940

GO:0007155

GO:0007260

GO:0007519

GO:0007595

GO:0008104

GO:0008283

GO:0008285

GO:0008289

GO:0009267

GO:0009617

GO:0009968

GO:0010524

GO:0010608

GO:0010628

GO:0010875

GO:0012501

GO:0015031

GO:0015485

GO:0016020

GO:0016050

GO:0016192

GO:0016323

GO:0016324

GO:0016504

GO:0019065

GO:0019217

GO:0019221

GO:0019899

GO:0019901

GO:0019915

GO:0023052

GO:0030154

GO:0030163

GO:0030193

GO:0030198

GO:0030301

GO:0030335

GO:0030512

GO:0030514

GO:0030666

GO:0030674

GO:0030857

GO:0030879

GO:0031267

GO:0031295

GO:0031397

GO:0031398

GO:0031410

GO:0031623

GO:0031901

GO:0032091

GO:0032092

GO:0032507

GO:0032570

GO:0032991

GO:0033137

GO:0033138

GO:0033484

GO:0034141

GO:0034330

GO:0036211

GO:0038016

GO:0042060

GO:0042310

GO:0042383

GO:0042532

GO:0042632

GO:0042802

GO:0043085

GO:0043226

GO:0043407

GO:0043409

GO:0043627

GO:0044325

GO:0044860

GO:0044877

GO:0045019

GO:0045121

GO:0045907

GO:0046426

GO:0046716

GO:0046982

GO:0048144

GO:0048147

GO:0048471

GO:0048550

GO:0048856

GO:0048870

GO:0050998

GO:0051001

GO:0051092

GO:0051117

GO:0051480

GO:0051592

GO:0051649

GO:0051899

GO:0052547

GO:0055065

GO:0055074

GO:0055085

GO:0060056

GO:0060090

GO:0060355

GO:0060546

GO:0061024

GO:0061099

GO:0070320

GO:0070836

GO:0071360

GO:0071375

GO:0071455

GO:0071560

GO:0071711

GO:0072584

GO:0086091

GO:0086098

GO:0090090

GO:0090263

GO:0097190

GO:0098772

GO:0098903

GO:0098909

GO:0098911

GO:0120162

GO:1900027

GO:1900085

GO:1901380

GO:1901844

GO:1903071

GO:1903361

GO:1903598

GO:1903609

GO:2000286

GO:2000535

GO:2000811

GO:2001238

GO:2001244

HMNXSV003015048

Hs.74034.1.S1_3p_at

ILMN_1687583

ILMN_2149226

PH_hs_0004233

TC07003339.hg

Z18951_at

g4580417_3p_s_at

Participates

as an output of

Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Homo sapiens)

as an input of

eNOS associates with Caveolin-1 (Homo sapiens)

This entity regulates

Positively

perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP (Homo sapiens)

Other forms of this molecule

CAV1 [Golgi membrane]

CAV1 [plasma membrane]

CAV1 [endocytic vesicle membrane]

CAV1 [early endosome membrane]

Inferred To

cav-1 [lipid droplet] (Caenorhabditis elegans)

cav1 [lipid droplet] (Xenopus tropicalis)

CAV1 [lipid droplet] (Bos taurus)

CAV1 [lipid droplet] (Canis familiaris)

CAV1 [lipid droplet] (Danio rerio)

CAV1 [lipid droplet] (Gallus gallus)

CAV1 [lipid droplet] (Sus scrofa)

Cav1 [lipid droplet] (Mus musculus)

Cav1 [lipid droplet] (Rattus norvegicus)

Homologues of CAV1 [lipid droplet] (Caenorhabditis elegans)

cav-2 [lipid droplet] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001744.2

OpenTargets

ENSG00000105974

GeneCards

Q03135

HPA

ENSG00000105974-CAV1

Ensembl

ENSP00000339191, ENSP00000384348, ENSP00000377111, ENST00000405348, ENST00000341049, ENSG00000105974, ENST00000393467, ENSP00000377110, ENST00000393468

PRO

Q03135

Pharos - Targets

Q03135

Orphanet

17896

PDB

7SC0

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.813	7
UniProt:P18031 PTPN1	2	PTPN1 [cytosol] (R-HSA-210625) PTPN1 [endosome membrane] (R-HSA-9815895)	0.697	5
UniProt:P51636 CAV2	2	CAV2 [plasma membrane] (R-HSA-9021035) CAV2 [Golgi membrane] (R-HSA-9021032)	0.669	4
UniProt:P0DTD1-PRO_0000449624 REP			0.659	3
UniProt:Q969G5 CAVN3			0.649	11
UniProt:Q6NZI2 CAVIN1	2	CAVIN1 [plasma membrane] (R-HSA-9714278) PTRF [nucleoplasm] (R-HSA-74981)	0.641	10
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.641	3
UniProt:P48995 TRPC1	1	TRPC1 [plasma membrane] (R-HSA-2089937)	0.633	7
UniProt:Q16881 TXNRD1	1	TXNRD1 [cytosol] (R-HSA-73531)	0.632	4
UniProt:P41134 ID1	1	ID1 [nucleoplasm] (R-HSA-2534101)	0.602	6
UniProt:O95810 CAVN2			0.602	6
UniProt:P20936 RASA1	1	RASA1 [cytosol] (R-HSA-186833)	0.59	2
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:O75581 LRP6	8	p-T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-205884) p-S1490-LRP6 [plasma membrane] (R-HSA-206156) LRP6 [early endosome membrane] (R-HSA-5368481) p-LRP6 [early endosome membrane] (R-HSA-5368496) LRP6N [extracellular region] (R-HSA-5334021) p-2S,S1490,2T-LRP6 [plasma membrane] (R-HSA-1458894) p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-1458895) LRP6 [plasma membrane] (R-HSA-206252)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P52735-1 VAV2			0.544	3
UniProt:Q03160	1	Grb7 [cytosol] (R-MMU-204819)	0.532	3
UniProt:P19174 PLCG1	6	p-Y-PLCG1 [cytosol] (R-HSA-9029082) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [plasma membrane] (R-HSA-167682) PLCG1 [cytosol] (R-HSA-202320) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084)	0.525	2
UniProt:O00194 RAB27B	5	GGC-RAB27B [melanosome membrane] (R-HSA-8877280) GGC-RAB27B [cytosol] (R-HSA-8873786) RAB27B [cytosol] (R-HSA-8873706) RAB27B [plasma membrane] (R-HSA-8862952) RAB27B [platelet dense granule membrane] (R-HSA-8862955)	0.524	2
UniProt:P0DOE7 MATRX			0.524	2
UniProt:P01112 HRAS	20	HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS Q61L [plasma membrane] (R-HSA-6802452) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS G12C [plasma membrane] (R-HSA-9656561) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788)	0.508	2
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.499	2
UniProt:P10586 PTPRF	2	PTPRF [plasma membrane] (R-HSA-6786486) PTPRF [endosome membrane] (R-HSA-9815889)	0.499	2
UniProt:P52735 VAV2	2	VAV2 [cytosol] (R-HSA-195012) p-Y172-VAV2 [cytosol] (R-HSA-442307)	0.499	2
UniProt:Q15208 STK38	1	STK38 [cytosol] (R-HSA-9715143)	0.499	3
UniProt:Q06124 PTPN11	4	p-Y542-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [nucleoplasm] (R-HSA-8937745) PTPN11 [cytosol] (R-HSA-162563) p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573)	0.499	2
UniProt:P29350 PTPN6	5	PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938)	0.499	2
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.483	2
UniProt:A0A0H3NFP4 A0A0H3NFP4			0.471	2
UniProt:Q07820 MCL1	1	MCL1 [cytosol] (R-HSA-5661490)	0.463	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.463	3
UniProt:P25445 FAS	1	FAS [plasma membrane] (R-HSA-66248)	0.463	3
UniProt:P55957 BID	4	MYS-BID(62-195) [mitochondrial outer membrane] (R-HSA-114266) MYS-BID(62-195) [cytosol] (R-HSA-141373) BID(1-195) [cytosol] (R-HSA-50825) BID(62-195) [cytosol] (R-HSA-139953)	0.463	3
UniProt:O70239	5	Axin1 [cytosol] (R-RNO-4641133) phospho-Axin1 [cytosol] (R-RNO-3640864) phospho-Axin1 [cytosol] (R-RNO-3640841) phospho-Axin1 [cytosol] (R-RNO-206040) Axin1 [cytosol] (R-RNO-195249)	0.463	5
UniProt:O15118 NPC1	1	NPC1 [lysosomal membrane] (R-HSA-5216153)	0.463	3
UniProt:P22307 SCP2	4	SCP2(425-547) [peroxisomal matrix] (R-HSA-9033522) SCP2(1-424) [peroxisomal matrix] (R-HSA-9033486) SCP2 [cytosol] (R-HSA-9033130) SCP2 [peroxisomal matrix] (R-HSA-2046067)	0.454	3

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