triacylglycerol + H2O -> diacylglycerol + fatty acid

Stable Identifier
R-HSA-163551
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated rat HSL at the lipid particle hydrolyzes triacylglycerol to yield diacylglycerol + fatty acid. In vitro, activated partially purified HSL catalyzes this reaction at only about two times the rate measured with non-activated enzyme (Fredrikson et al. 1981). The much greater rate increase caused by HSL phosphorylation in vivo appears to be due to its phosphorylation-dependent translocation to the surface of the lipid particle (Birnbaum 2003).

HSL-mediated triacylglycerol hydrolysis in humans has not been studied in detail, so the human reaction is inferred from the well-studied rat one.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
triglyceride lipase activity of phosphorylated HSL dimer:FABP4 complex [lipid droplet]
Physical Entity
Activity
Inferred From
Authored
Created