PKA activation

Stable Identifier
R-HSA-163615
Type
Pathway
Species
Homo sapiens
Compartment
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Summation

A number of inactive tetrameric PKA holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. When cAMP binds to two specific binding sites on the regulatory subunits, these undergo a conformational change that causes the dissociation of a dimer of regulatory subunits bound to four cAMP from two monomeric, catalytically active PKA subunits.

Literature References
PubMed ID Title Journal Year
2165385 cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes

Taylor, SS, Buechler, JA, Yonemoto, W

Annu Rev Biochem 1990
Participants
Participant Of
Event Information
Orthologous Events
Cross References
BioModels Database
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