G alpha (s) activates adenylate cyclase

Stable Identifier
R-HSA-163617
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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G(s)-alpha:GTP binds to inactive adenylate cyclase, causing a conformational transition in adenylate cyclase exposing the catalytic site and activating it.
Literature References
PubMed ID Title Journal Year
12058044 Mechanism of Galpha i-mediated inhibition of type V adenylyl cyclase

Chen-Goodspeed, M, Chen, J, Dessauer, CW

J. Biol. Chem. 2002
9417641 Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS

Sunahara, RK, Tesmer, JJ, Gilman, AG, Sprang, SR

Science 1997
Participants
Participates
Catalyst Activity

adenylate cyclase activator activity of G alpha (s):GTP [plasma membrane]

Orthologous Events
Authored
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Created
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