G alpha (s) activates adenylate cyclase

Stable Identifier
R-HSA-163617
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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G(s)-alpha:GTP binds to inactive adenylate cyclase, causing a conformational transition in adenylate cyclase exposing the catalytic site and activating it.

Literature References
PubMed ID Title Journal Year
9417641 Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS

Tesmer, JJ, Sunahara, RK, Gilman, AG, Sprang, SR

Science 1997
12058044 Mechanism of Galpha i-mediated inhibition of type V adenylyl cyclase

Dessauer, CW, Chen-Goodspeed, M, Chen, J

J. Biol. Chem. 2002
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