Glucagon binds to Glucagon receptor

Stable Identifier
R-HSA-163625
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Glucagon (Thomsen J et al, 1972) is an important peptide hormone produced by the pancreas. It is released when the glucose level in the blood is low (hypoglycemia), causing the liver to convert stored glycogen into glucose and release it into the bloodstream. The action of glucagon is thus opposite to that of insulin. Glucagon, together with glucagon-like peptide 1 (GLP-1) and glucagon-like peptide 2 (GLP-2), are peptide hormones encoded by a single common prohormone precursor, proglucagon.The glucagon receptor (Lok S et al, 1994) plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by coupling to Gs and q, which stimulate adenylyl cyclase and a phosphatidylinositol-calcium second messenger system respectively.

Literature References
PubMed ID Title Journal Year
15464082 Hepatic glucagon receptor binding and glucose-lowering in vivo by peptidyl and non-peptidyl glucagon receptor antagonists

Dallas-Yang, Q, Shen, X, Strowski, M, Brady, E, Saperstein, R, Gibson, RE, Szalkowski, D, Qureshi, SA, Candelore, MR, Fenyk-Melody, JE, Parmee, ER, Zhang, BB, Jiang, G

Eur J Pharmacol 2004
11946536 The amino acid sequence of human glucagon

Thomsen, J, Kristiansen, K, Brunfeldt, K, Sundby, F

FEBS Lett 1972
2826231 Identification of the lesion in the stimulatory GTP-binding protein of the uncoupled S49 lymphoma

Rall, T, Harris, BA

FEBS Lett 1987
8144028 The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization

Lok, S, Kuijper, JL, Jelinek, LJ, Kramer, JM, Whitmore, TE, Sprecher, CA, Mathewes, S, Grant, FJ, Biggs, SH, Rosenberg, GB

Gene 1994
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