D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate

Stable Identifier
R-HSA-163741
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic transketolase (TKT) catalyzes the reversible reaction of D-glyceraldehyde 3-phosphate and sedoheptulose 7-phosphate to form D-xylulose 5-phosphate and D-ribose 5-phosphate. The active transketolase enzyme is a homodimer with one molecule of thiamine pyrophosphate and magnesium bound to each monomer (Wang et al. 1997).

Literature References
PubMed ID Title Journal Year
9357955 Aspartate 155 of human transketolase is essential for thiamine diphosphate-magnesium binding, and cofactor binding is required for dimer formation

Wang, JJ, Martin, PR, Singleton, CK

Biochim Biophys Acta 1997
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
transketolase activity of TKT dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Created