D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate

Stable Identifier
R-HSA-163764
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
TALDO1 transforms Fru(6)P and E4P to sedoheptulose 7-phosphate and GA3P
ReviewStatus
5/5
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D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
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Dimeric cytosolic transaldolase (TALDO1) catalyzes the reversible reaction of D-erythrose 4-phosphate and D-fructose 6-phosphate to form D-glyceraldehyde 3-phosphate and sedoheptulose 7-phosphate. Protein expressed from the cloned gene has been characterized biochemically and crystallographically (Banki et al. 1994; Thorell et al. 2000) and transaldolase deficiency in a patient has been correlated with a mutation in the TALDO1 gene (Verhoeven et al. 2001).
Literature References
PubMed ID Title Journal Year
11283793 Transaldolase deficiency: liver cirrhosis associated with a new inborn error in the pentose phosphate pathway.

Verhoeven, NM, van der Knaap, MS, Salomons, GS, Struys, EA, Douwes, AC, Jakobs, C, Huck, JHJ, Roos, B

Am J Hum Genet 2001
10869557 The three-dimensional structure of human transaldolase

Schneider, G, Banki, K, Thorell, S, Gergely, P, Perl, A

FEBS Lett. 2000
8300619 Cloning and expression of the human gene for transaldolase. A novel highly repetitive element constitutes an integral part of the coding sequence

Banki, K, Perl, A, Halladay, D

J Biol Chem 1994
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Event Information
Reverse Reaction
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Homo sapiens)
Catalyst Activity

transaldolase activity of TALDO1 dimer [cytosol]

Physical Entity
TALDO1 dimer [cytosol] (Homo sapiens)
Activity
transaldolase activity (GO:0004801)
Orthologous Events
D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Bos taurus)
D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)
D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Canis familiaris)
D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Danio rerio)
D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)
D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Drosophila melanogaster)
D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Gallus gallus)
D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Mus musculus)
D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Rattus norvegicus)
D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Saccharomyces cerevisiae)
D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Schizosaccharomyces pombe)
D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Sus scrofa)
D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Xenopus tropicalis)
Cross References
Rhea
Created
Gopinathrao, G  (2005-05-06)
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