ChREBP activates metabolic gene expression

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R-HSA-163765
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Homo sapiens
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ChREBP (Carbohydrate Response Element Binding Protein) is a large multidomain protein containing a nuclear localization signal near its amino terminus, polyproline domains, a basic helix-loop-helix-leucine zipper domain, and a leucine-zipper-like domain (Uyeda et al., 2002). Its dephosphorylation in response to molecular signals associated with the well-fed state allows it to enter the nucleus, interact with MLX protein, and bind to ChRE DNA sequence motifs near Acetyl-CoA carboxylase, Fatty acid synthase, and Pyruvate kinase (L isoform) genes (Ishi et al.2004). This sequence of events is outlined schematically in the picture below (adapted from Kawaguchi et al. (2001) - copyright (2001) National Academy of Sciences, U.S.A.).

Literature References
PubMed ID Title Journal Year
11698644 Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein

Kawaguchi, T, Takenoshita, M, Kabashima, T, Uyeda, K

Proc Natl Acad Sci U S A 2001
15118080 Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis

Iizuka, K, Bruick, RK, Liang, G, Horton, JD, Uyeda, K

Proc Natl Acad Sci U S A 2004
15664996 Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.

Ma, L, Tsatsos, NG, Towle, HC

J Biol Chem 2005
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