Reactome: A Curated Pathway Database

Phosphorylation of PF2K-Pase by PKA catalytic subunit

Stable Identifier
R-HSA-163773
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Activated PKA (protein kinase A) phosphorylates serine 36 of the bifunctional 6-Phosphofructo-2-kinase /Fructose-2,6-bisphosphatase (PFKFB1) enzyme. This phosphorylation inhibits the enzyme's phosphofructokinase (PFK-2) activity while activating its phosphatase activity. As a result, cytosolic levels of Fructose-2,6-bisphosphate (F-2,6-P2) are reduced. F-2,6-P2 in turn is a key positive regulator of the committed step of glycolysis, so the net effect of this phosphorylation event is a reduced rate of glycolysis.

Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
cAMP-dependent protein kinase activity of PKA catalytic subunit [cytosol] PKA catalytic subunit [cytosol] cAMP-dependent protein kinase activity (0004691)
Inferred From