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Phosphorylation of PF2K-Pase by PKA catalytic subunit

Stable Identifier
R-HSA-163773
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Activated PKA (protein kinase A) phosphorylates serine 36 of the bifunctional 6-Phosphofructo-2-kinase /Fructose-2,6-bisphosphatase (PFKFB1) enzyme. This phosphorylation inhibits the enzyme's phosphofructokinase (PFK-2) activity while activating its phosphatase activity. As a result, cytosolic levels of Fructose-2,6-bisphosphate (F-2,6-P2) are reduced. F-2,6-P2 in turn is a key positive regulator of the committed step of glycolysis, so the net effect of this phosphorylation event is a reduced rate of glycolysis.

Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
cAMP-dependent protein kinase activity of PKA catalytic subunit [cytosol]
Physical Entity
Activity
Inferred From