FGFR2 W290C [plasma membrane]

Stable Identifier
R-HSA-1637929
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
FGFR2 W290C [plasma membrane] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
17344846 Patterns of somatic mutation in human cancer genomes

Easton, DF, Dicks, E, Stratton, MR, Davies, H, Louis, DN, Tofts, C, Teh, BT, Edkins, S, Teague, J, Futreal, PA, Forbes, S, Vastrik, I, Varian, J, Wooster, R, Birney, E, Gray, K, Jones, D, Hinton, J, Hunter, C, Schmidt, EE, Yates, A, Greenman, C, Halliday, K, Yuen, ST, Hills, K, O'Meara, S, Khoo, SK, Green, AR, Jenkinson, A, Greaves, MF, Perry, J, Menzies, A, DeFazio, A, Nicholson, AG, Clements, J, Dalgliesh, GL, Chiew, YE, Choudhury, B, Chenevix-Trench, G, Harrison, R, Campbell, P, Cahill, DP, Leung, SY, Bhamra, G, Butler, A, Stephens, P, Stevens, C, Cole, J, Small, A, Brasseur, F, Smith, R, Buck, G, Raine, K, Barthorpe, S, Shepherd, R, Bignell, G, Webb, T, Tan, MH, Mironenko, T, Richardson, D, Avis, T, Looijenga, L, Weber, BL, West, S, Widaa, S, Goldstraw, P

Nature 2007
9150725 Trp290Cys mutation in exon IIIa of the fibroblast growth factor receptor 2 (FGFR2) gene is associated with Pfeiffer syndrome

Di Rocco, C, Tartaglia, M, Valeri, S, Battaglia, PA, Velardi, F

Hum Genet 1997
16140923 Somatic mutations of the protein kinase gene family in human lung cancer

Easton, DF, Dicks, E, Stratton, MR, Davies, H, Cooper, CS, Tofts, C, Teh, BT, Edkins, S, Teague, J, Pierotti, MA, Futreal, PA, Webb, A, Forbes, S, Flanagan, AM, Kosmidou, V, Lakhani, SR, Laman, R, Jones, D, Knowles, M, Hinton, J, Hunter, C, Yates, A, Greenman, C, Halliday, K, Yuen, ST, Hills, K, O'Meara, S, Perry, J, Malkowicz, B, Menzies, A, Parker, A, Nicholson, AG, Clements, J, Edwards, K, Green, A, Looijenga, LH, Harrison, R, Lugg, R, Leung, SY, Butler, A, Stephens, P, Stephens, Y, Stevens, C, Cole, J, Brackenbury, L, Small, A, Brasseur, F, Smith, R, Buck, G, Solomon, H, Raine, K, Barthorpe, S, Shepherd, R, Bignell, G, Petty, R, Avis, T, Weber, BL, West, S, Widaa, S, Goldstraw, P, Gorton, M, Gray, K, Wooster, R, Varian, J

Cancer Res 2005
18552176 Drug-sensitive FGFR2 mutations in endometrial carcinoma

Akslen, LA, Cibulskis, K, Greulich, H, Dutt, A, Sellers, WR, Chen, TH, Winckler, W, Wyhs, N, Ziaugra, L, Zody, MC, Salvesen, HB, Meyerson, M, Stefansson, IM, Trovik, J, Wong, KK, Ramos, AH, Richter, DJ, Gabriel, S, Nicoletti, R, Onofrio, RC, Grewal, R, Hanna, M, Hatton, C, Engelsen, IB, Fennell, T

Proc Natl Acad Sci U S A 2008
External Reference Information
External Reference
Gene Names
FGFR2, BEK, KGFR, KSAM
Chain
signal peptide:1-21, chain:22-821
Participates
Other forms of this molecule
Modified Residues
Name
L-tryptophan 290 replaced with L-cysteine
Coordinate
290
PsiMod
A protein modification that effectively converts a source amino acid residue to an L-cysteine.
A protein modification that effectively removes or replaces an L-tryptophan.
Disease
Name Identifier Synonyms
lung cancer DOID:1324
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
bone development disease DOID:0080006
Pfeiffer syndrome DOID:14705 acrocephalosyndactylia type V
Cross References
COSMIC
Interactors (30)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P09038 FGF2  1 0.779 5
 UniProt:P51812 RPS6KA3  7 0.745 5
 UniProt:P62993 GRB2  1 0.735 6
 ChEBI:73280 SSR      0.683 8
 UniProt:P05230 FGF1  1 0.675 3
 UniProt:P11362 FGFR1  9 0.623 3
 UniProt:O15520 FGF10  1 0.571 2
 UniProt:P19174 PLCG1  6 0.528 3
 UniProt:Q3MIR4 CC50B      0.527 2
 UniProt:O60637 TSN3      0.527 2
 UniProt:Q96LL9 DJC30      0.527 2
 UniProt:Q6P047 CH074      0.527 2
 UniProt:Q99732 LITAF      0.527 2
 UniProt:Q8N7X8 SIGL1      0.527 2
 UniProt:Q5T9A4 ATAD3B  3 0.527 2
 UniProt:Q96HB5 CC120      0.527 2
 UniProt:Q8IWX8 CHERP  1 0.527 2
 UniProt:Q92551 IP6K1  2 0.527 2
 UniProt:Q6P995 F171B      0.527 2
 UniProt:P34741 SDC2  20 0.527 2
 UniProt:Q92575 UBXN4      0.527 2
 UniProt:Q96L94 SNX22      0.527 2
 UniProt:P01033 TIMP1  4 0.527 2
 UniProt:Q96G30 MRAP2      0.527 2
 UniProt:P55899 FCGRN      0.527 2
 UniProt:Q5TF58 IFFO2      0.527 2
 UniProt:Q06124 PTPN11  4 0.519 2
 UniProt:Q9ULH0 KIDINS220  2 0.483 2
 UniProt:Q9UBH6 S53A1      0.483 2
 UniProt:Q86VI4 LAP4B      0.463 2
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