UGCG transfers glucose to ceramide

Stable Identifier
Reaction [transition]
Homo sapiens
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Ceramide glucosyltransferase (UGCG, CGT, GCS) catalyzes the first glycosylation step in glycosphingolipid biosynthesis by transferring glucose to ceramide (Ichikawa et al. 1996). UGCG is localized on the cytosolic part of the cis-Golgi membrane. The cytosolic PLEKHA8 (FAPP2) will transport the product GlcCer to the plasma membrane. GlcCer is also transported to the inside of the Golgi membrane by MDR1 ("flipping"; Fabiana de Rosa et al., 2004; Eckford & Sharom, 2005; reviewed by Liu & Li, 2013).
Literature References
PubMed ID Title Journal Year
8643456 Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis

Suzuki, G, Hidari, KI, Hirabayashi, Y, Sakiyama, H, Ichikawa, S

Proc Natl Acad Sci U S A 1996
23290777 Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance

Liu, YY, Hill, RA, Li, YT

Adv. Cancer Res. 2013
15799713 The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids

Eckford, PD, Sharom, FJ

Biochem J 2005
14662772 Role of multiple drug resistance protein 1 in neutral but not acidic glycosphingolipid biosynthesis

Sillence, D, Lingwood, C, De Rosa, MF, Ackerley, C

J Biol Chem 2004
Catalyst Activity

ceramide glucosyltransferase activity of UGCG [Golgi membrane]

Orthologous Events
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