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PPP2R5E [cytosol]
Stable Identifier
R-HSA-1638770
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PP2A -56 kDa regulatory subunit B epsilon isoform
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by WNT in cancer (Homo sapiens)
Signaling by AMER1 mutants (Homo sapiens)
Truncations of AMER1 destabilize the destruction complex (Homo sapiens)
Truncated AMER1 mutants destabilize the destruction complex (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Signaling by APC mutants (Homo sapiens)
APC truncation mutants have impaired AXIN binding (Homo sapiens)
APC truncation mutants have impaired AXIN binding (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Signaling by AXIN mutants (Homo sapiens)
AXIN missense mutants destabilize the destruction complex (Homo sapiens)
AXIN mutants destabilize the destruction complex (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Signaling by CTNNB1 phospho-site mutants (Homo sapiens)
CTNNB1 S33 mutants aren't phosphorylated (Homo sapiens)
CTNNB1 S33 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
pS37,T41,S45-CTNNB1 S33 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
CTNNB1 S37 mutants aren't phosphorylated (Homo sapiens)
CTNNB1 S37 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
pT41,S45-CTNNB1 S37 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
CTNNB1 S45 mutants aren't phosphorylated (Homo sapiens)
CTNNB1 S45 mutants aren't phosphorylated by CK1alpha (Homo sapiens)
CTNNB1 S45 mutants:AXIN:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
CTNNB1 T41 mutants aren't phosphorylated (Homo sapiens)
CTNNB1 T41 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
pS45-CTNNB1 T41 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Signaling by GSK3beta mutants (Homo sapiens)
Misspliced GSK3beta mutants stabilize beta-catenin levels (Homo sapiens)
pS45-beta-catenin:p-Axin:GSK3 del304-316:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3 del304-316:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet sensitization by LDL (Homo sapiens)
PECAM-1 binds PP2A (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-PECAM:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-inhibition by CTLA4 (Homo sapiens)
CTLA-4 binds B7-1/B7-2 (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Dephosphorylation of AKT by PP2A (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
PP2A binds CTLA4 dimer (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Phosphorylation of CTLA-4 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Co-stimulation by CD28 (Homo sapiens)
CD28 homodimer binds B7-1 homodimer (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
CD28 homodimer binds B7-2 monomer (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-Y307-PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
PP2A dephosphorylates RAF1 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
RAF activation (Homo sapiens)
PP2A dephosphorylates KSR1 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
PP2A dephosphorylates inactive RAFs (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
AXIN is phosphorylated in the destruction complex (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Assembly of the destruction complex (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Homo sapiens)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Association of beta-catenin with the destruction complex (Homo sapiens)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Beta-catenin phosphorylation cascade (Homo sapiens)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Homo sapiens)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Homo sapiens)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Homo sapiens)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Homo sapiens)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Degradation of ubiquitinated beta catenin by the proteasome (Homo sapiens)
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Homo sapiens)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Homo sapiens)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Homo sapiens)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Phosphorylation of APC component of the destruction complex (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
Beta-catenin is released from the destruction complex (Homo sapiens)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex (Homo sapiens)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16537 PPP2R5E
Gene Names
PPP2R5E
Chain
initiator methionine:, chain:2-467
Reference Genes
BioGPS Gene:5529 PPP2R5E
COSMIC (genes):PPP2R5E PPP2R5E
CTD Gene:5529 PPP2R5E
dbSNP Gene:5529 PPP2R5E
ENSEMBL:ENSG00000154001 PPP2R5E
HGNC:9313 PPP2R5E
KEGG:hsa:5529 PPP2R5E
Monarch:5529 PPP2R5E
NCBI Gene:5529 PPP2R5E
OMIM:601647 PPP2R5E
UCSC:Q16537 PPP2R5E
Reference Transcript
RefSeq:XM_047431543.1 PPP2R5E
RefSeq:NM_001282179.3 PPP2R5E
RefSeq:NM_001282180.3 PPP2R5E
RefSeq:XM_047431544.1 PPP2R5E
RefSeq:NM_001282181.3 PPP2R5E
RefSeq:XM_024449647.2 PPP2R5E
RefSeq:XM_054376318.1 PPP2R5E
RefSeq:NM_006246.5 PPP2R5E
RefSeq:NM_001282182.3 PPP2R5E
RefSeq:XM_054376319.1 PPP2R5E
Other Identifiers
11730271_at
11730272_a_at
11748296_a_at
11748297_s_at
11759023_at
11759024_at
11759025_s_at
16793721
203338_PM_at
203338_at
227630_PM_at
227630_at
228070_PM_at
228070_at
229322_PM_at
229322_at
2361184
3051984
3051987
3051990
3051991
3051992
32734_at
3567985
3567986
3567987
3567988
3567989
3567990
3567992
3567993
3567994
3567995
3567996
3567997
3567998
3568005
3568009
3568017
3568018
3568019
3568035
3568036
3568037
3568038
3568039
3568040
3568041
3568049
3568050
3568051
53735_at
5529
56629_at
56638_g_at
76264_at
7979551
A_23_P3042
A_24_P5026
GE57793
GO:0000159
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0007165
GO:0019888
GO:0043226
GO:0072542
GO:0098772
HMNXSV003032848
Hs.122684.1.S1_3p_at
Hs.283362.0.A1_3p_at
Hs.319817.0.A1_3p_at
ILMN_1666761
L76703_at
PH_hs_0027933
TC14001206.hg
g5453955_3p_at
Participates
as a candidate of
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
Inferred To
ppp2r5e [cytosol]
(Xenopus tropicalis)
par1 [cytosol]
(Schizosaccharomyces pombe)
Homologues of PPP2R5E [cytosol]
(Schizosaccharomyces pombe)
PPP2R5E [cytosol]
(Bos taurus)
PPP2R5E [cytosol]
(Canis familiaris)
PPP2R5E [cytosol]
(Gallus gallus)
PPP2R5E [cytosol]
(Sus scrofa)
Ppp2r5e [cytosol]
(Mus musculus)
Ppp2r5e [cytosol]
(Rattus norvegicus)
psrA [cytosol]
(Dictyostelium discoideum)
RTS1 [cytosol]
(Saccharomyces cerevisiae)
par2 [cytosol]
(Schizosaccharomyces pombe)
wdb [cytosol]
(Drosophila melanogaster)
pptr-1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_054232294.1
,
NP_001269110.1
,
XP_054232293.1
,
XP_024305415.1
,
NP_001269111.1
,
XP_047287500.1
,
XP_047287499.1
,
NP_006237.1
,
NP_001269108.1
,
NP_001269109.1
OpenTargets
ENSG00000154001
ENSEMBL
ENST00000555899
,
ENSG00000154001
,
ENSP00000452396
,
ENSP00000337641
,
ENST00000422769
,
ENST00000337537
,
ENSP00000404632
HPA
ENSG00000154001-PPP2R5E
GeneCards
PPP2R5E
PRO
Q16537
Pharos - Targets
Q16537
PDB
8UWB
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P67775 PPP2CA
4
PPP2CA [cytosol]
(R-HSA-165971)
PPP2CA [nucleoplasm]
(R-HSA-165978)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
0.855
7
UniProt:P56704 WNT3A
10
N4GlycoAsn-PalmS WNT3A [plasma membrane]
(R-HSA-3247807)
N4GlycoAsn-PalmS WNT3A [extracellular region]
(R-HSA-3247784)
N4GlycoAsn-PalmS WNT3A [Golgi lumen]
(R-HSA-3247832)
N4GlycoAsn-PalmS WNT3A [endoplasmic reticulum lumen]
(R-HSA-3238344)
N4GlycoAsn-WNT3A [endoplasmic reticulum lumen]
(R-HSA-3238231)
WNT3A [endoplasmic reticulum lumen]
(R-HSA-3238292)
N4GlycoAsn-PalmS WNT3A [early endosome membrane]
(R-HSA-5368483)
N4GlycoAsn-PalmS WNT3A [endocytic vesicle membrane]
(R-HSA-3781944)
N4GlycoAsn-PalmS WNT3A [extracellular exosome]
(R-HSA-3781968)
WNT3A [extracellular region]
(R-HSA-201710)
0.643
4
UniProt:Q9H0H5 RACGAP1
1
RACGAP1 [cytosol]
(R-HSA-195122)
0.593
5
UniProt:Q86YF9 DZIP1
1
DZIP1 [nucleoplasm]
(R-HSA-5635020)
0.581
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
15
UniProt:P51959 CCNG1
1
CCNG1 [nucleoplasm]
(R-HSA-6792489)
0.527
2
UniProt:Q5FBB7 SGO1
3
SGOL1 [cytosol]
(R-HSA-376227)
SGO1 [nucleoplasm]
(R-HSA-2468161)
p-S-SGO1 [nucleoplasm]
(R-HSA-9929718)
0.527
3
UniProt:Q9UIH9 KLF15
1
KLF15 [nucleoplasm]
(R-HSA-8878735)
0.527
2
UniProt:Q99677 LPAR4
1
LPAR4 [plasma membrane]
(R-HSA-418020)
0.527
2
UniProt:O96017 CHEK2
3
p-S,3T-CHEK2 [nucleoplasm]
(R-HSA-5683784)
CHEK2 [nucleoplasm]
(R-HSA-113824)
p-T68-CHEK2 [nucleoplasm]
(R-HSA-113825)
0.508
3
UniProt:Q9HC29 NOD2
1
NOD2 [cytosol]
(R-HSA-168411)
0.508
2
UniProt:P05919 vpu
6
VPU (P05919) protein [cytosol]
(R-HIV-173223)
VPU (P05919) [endoplasmic reticulum membrane]
(R-HIV-180550)
VPU (P05919) protein [extracellular region]
(R-HIV-175522)
VPU (P05919) protein [nucleoplasm]
(R-HIV-175200)
VPU (P05919) [Golgi membrane]
(R-HIV-3149439)
VPU (P05919) [plasma membrane]
(R-HIV-3149423)
0.462
2
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