Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
PPP2R5E [cytosol]
Stable Identifier
R-HSA-1638770
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PP2A -56 kDa regulatory subunit B epsilon isoform
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction (Homo sapiens)
Signaling by WNT in cancer (Homo sapiens)
AMER1 mutants destabilize the destruction complex (Homo sapiens)
Truncations of AMER1 destabilize the destruction complex (Homo sapiens)
Truncated AMER1 mutants destabilize the destruction complex (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
AXIN mutants destabilize the destruction complex, activating WNT signaling (Homo sapiens)
AXIN missense mutants destabilize the destruction complex (Homo sapiens)
AXIN mutants destabilize the destruction complex (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Misspliced GSK3beta mutants stabilize beta-catenin (Homo sapiens)
Misspliced GSK3beta mutants stabilize beta-catenin levels (Homo sapiens)
pS45-beta-catenin:p-Axin:GSK3 del304-316:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3 del304-316:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex (Homo sapiens)
S33 mutants of beta-catenin aren't phosphorylated (Homo sapiens)
CTNNB1 S33 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
pS37,T41,S45-CTNNB1 S33 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
S37 mutants of beta-catenin aren't phosphorylated (Homo sapiens)
CTNNB1 S37 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
pT41,S45-CTNNB1 S37 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
S45 mutants of beta-catenin aren't phosphorylated (Homo sapiens)
CTNNB1 S45 mutants aren't phosphorylated by CK1alpha (Homo sapiens)
CTNNB1 S45 mutants:AXIN:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
T41 mutants of beta-catenin aren't phosphorylated (Homo sapiens)
CTNNB1 T41 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
pS45-CTNNB1 T41 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
truncated APC mutants destabilize the destruction complex (Homo sapiens)
APC truncation mutants have impaired AXIN binding (Homo sapiens)
APC truncation mutants have impaired AXIN binding (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet sensitization by LDL (Homo sapiens)
PECAM-1 binds PP2A (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-PECAM:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CTLA4 inhibitory signaling (Homo sapiens)
CTLA-4 binds B7-1/B7-2 (Homo sapiens)
CTLA-4:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
CTLA-4:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Dephosphorylation of AKT by PP2A (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
PP2A binds CTLA4 homodimer (Homo sapiens)
CTLA-4:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Phosphorylation of CTLA-4 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
CTLA-4:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
PP2A dephosphorylates RAF1 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
RAF activation (Homo sapiens)
PP2A dephosphorylates KSR1 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
PP2A dephosphorylates inactive RAFs (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-Y307-PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
PP2A dephosphorylates RAF1 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
RAF activation (Homo sapiens)
PP2A dephosphorylates KSR1 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
PP2A dephosphorylates inactive RAFs (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
AXIN is phosphorylated in the destruction complex (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Assembly of the destruction complex (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Homo sapiens)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Association of beta-catenin with the destruction complex (Homo sapiens)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Beta-catenin phosphorylation cascade (Homo sapiens)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Homo sapiens)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Homo sapiens)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Homo sapiens)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Homo sapiens)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Degradation of ubiquitinated beta catenin by the proteasome (Homo sapiens)
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Homo sapiens)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Homo sapiens)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Homo sapiens)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
Phosphorylation of APC component of the destruction complex (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
Beta-catenin is released from the destruction complex (Homo sapiens)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex (Homo sapiens)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5E [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16537 PPP2R5E
Gene Names
PPP2R5E
Chain
initiator methionine:1, chain:2-467
Reference Genes
BioGPS Gene:5529 PPP2R5E
COSMIC (genes):PPP2R5E PPP2R5E
CTD Gene:5529 PPP2R5E
dbSNP Gene:5529 PPP2R5E
ENSEMBL:ENSG00000154001 PPP2R5E
HGNC:9313 PPP2R5E
KEGG Gene (Homo sapiens):5529 PPP2R5E
Monarch:5529 PPP2R5E
NCBI Gene:5529 PPP2R5E
OMIM:601647 PPP2R5E
UCSC:Q16537 PPP2R5E
Reference Transcript
RefSeq:NM_001282182.1 PPP2R5E
RefSeq:NM_001282181.1 PPP2R5E
RefSeq:NM_001282179.1 PPP2R5E
RefSeq:NM_006246.3 PPP2R5E
RefSeq:NM_001282180.1 PPP2R5E
Other Identifiers
0001230711
11730271_at
11730272_a_at
11748296_a_at
11748297_s_at
11759023_at
11759024_at
11759025_s_at
16793721
203338_at
227630_at
228070_at
229322_at
2361184
3051984
3051987
3051990
3051991
3051992
32734_at
3567985
3567986
3567987
3567988
3567989
3567990
3567992
3567993
3567994
3567995
3567996
3567997
3567998
3568005
3568009
3568018
3568035
3568036
3568037
3568038
3568039
3568040
3568041
3568049
3568050
3568051
53735_at
5529
56629_at
56638_g_at
6034
72342
76264_at
7979551
A_23_P3042
A_24_P5026
AAB69752
AAH93766
AAI01480
AAI43232
AAI43235
AK316430
AL118555
AL132992
AL136038
BAH14801
BC093766
BC101479
BC143231
BC143234
CAA93153
CAB072342
CCDS61467
CCDS61468
CCDS9758
ENSG00000154001
ENSP00000337641
ENSP00000404632
ENSP00000452396
ENST00000337537
ENST00000337537.7
ENST00000422769
ENST00000422769.6
ENST00000555899
ENST00000555899.1
EntrezGene:5529
EntrezGene:PPP2R5E
g5453955_3p_at
GE57793
GO:0000159
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005829
GO:0006464
GO:0006470
GO:0007165
GO:0008150
GO:0019888
GO:0030234
GO:0031952
GO:0032991
GO:0043226
GO:0043666
GO:0072542
HGNC:9313
HPA006034
Hs.122684.1.S1_3p_at
Hs.283362.0.A1_3p_at
Hs.319817.0.A1_3p_at
ILMN_1666761
IPR002554
IPR011989
IPR016024
L76703
L76703_at
MIM:601647
NM_001282179
NM_001282180
NM_001282181
NM_001282182
NM_006246
NP_001269108
NP_001269109
NP_001269110
NP_001269111
NP_006237
NR_104104
PF01603
PH_hs_0027933
PPP2R5E
PPP2R5E-201
PPP2R5E-202
PPP2R5E-204
TC14001206.hg
UPI0000124E94
UPI000189A785
UPI00020659E9
XM_024449647
XP_024305415
Z69029
Participant Of
hasCandidate
PP2A regulatory subunit B56 [cytosol]
Inferred To
Homologues of PPP2R5E [cytosol] (Schizosaccharomyces pombe)
PPP2R5E [cytosol] (Bos taurus)
PPP2R5E [cytosol] (Caenorhabditis elegans)
PPP2R5E [cytosol] (Canis familiaris)
PPP2R5E [cytosol] (Danio rerio)
PPP2R5E [cytosol] (Dictyostelium discoideum)
PPP2R5E [cytosol] (Drosophila melanogaster)
PPP2R5E [cytosol] (Gallus gallus)
PPP2R5E [cytosol] (Mus musculus)
PPP2R5E [cytosol] (Rattus norvegicus)
PPP2R5E [cytosol] (Saccharomyces cerevisiae)
PPP2R5E [cytosol] (Schizosaccharomyces pombe)
PPP2R5E [cytosol] (Sus scrofa)
PPP2R5E [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_001269109.1
,
NP_001269110.1
,
NP_006237.1
,
NP_001269108.1
,
NP_001269111.1
OpenTargets
ENSG00000154001
GeneCards
Q16537
PRO
Q16537
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H0H5 RACGAP1
1
RACGAP1 [cytosol]
(R-HSA-195122)
0.593
5
UniProt:Q86YF9 DZIP1
1
DZIP1 [nucleoplasm]
(R-HSA-5635020)
0.581
3
UniProt:Q9HC29 NOD2
1
NOD2 [cytosol]
(R-HSA-168411)
0.508
2
UniProt:O96017 CHEK2
3
p-T68-CHEK2 [nucleoplasm]
(R-HSA-113825)
p-S,3T-CHEK2 [nucleoplasm]
(R-HSA-5683784)
CHEK2 [nucleoplasm]
(R-HSA-113824)
0.508
3
UniProt:P05919 vpu
6
VPU (P05919) protein [cytosol]
(R-HIV-173223)
VPU (P05919) protein [extracellular region]
(R-HIV-175522)
VPU (P05919) protein [nucleoplasm]
(R-HIV-175200)
VPU (P05919) [endoplasmic reticulum membrane]
(R-HIV-180550)
VPU (P05919) [Golgi membrane]
(R-HIV-3149439)
VPU (P05919) [plasma membrane]
(R-HIV-3149423)
0.462
2
© 2019
Reactome