Reactome | p-STAG2 [chromosome]

p-STAG2 [chromosome]

Stable Identifier

R-HSA-1638793

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

chromosome

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - Resolution of Sister Chromatid Cohesion (Homo sapiens)
        
        Phosphorylation of cohesin by PLK1 at chromosomal arms (Homo sapiens)
        
        Sister Chromosomal Arms:p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin [chromosome] (Homo sapiens)
        
        p-STAG2 [chromosome] (Homo sapiens)
        
        Resolution of sister chromatids (Homo sapiens)
        
        Sister Chromosomal Arms:p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin [chromosome] (Homo sapiens)
        
        p-STAG2 [chromosome] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8N3U4 STAG2

Gene Names

STAG2, SA2

Chain

chain:1-1231

Reference Genes

COSMIC (genes):STAG2 STAG2

dbSNP Gene:10735 STAG2

ENSEMBL:ENSG00000101972 STAG2

Participates

as a component of

p-STAG2,RAD21-Ac-Cohesin [chromosome] (Homo sapiens)

Other forms of this molecule

monoSUMO1-K-STAG2 [nucleoplasm]

STAG2 [cytosol]

p-STAG2 [cytosol]

p-STAG2 [chromosome, centromeric region]

STAG2 [chromosome]

STAG2 [chromosome, centromeric region]

STAG2 [nucleoplasm]

Inferred To

phospho-IRR1 [chromosome] (Saccharomyces cerevisiae)

phospho-scc-3 [chromosome] (Caenorhabditis elegans)

phospho-Stag2 [chromosome] (Mus musculus)

phospho-Stag2 [chromosome] (Rattus norvegicus)

phospho-SA2 [chromosome] (Drosophila melanogaster)

phospho-SA1 [chromosome] (Drosophila melanogaster)

phospho-p-STAG2 [chromosome] (Canis familiaris)

phospho-p-STAG2 [chromosome] (Dictyostelium discoideum)

phospho-p-STAG2 [chromosome] (Gallus gallus)

Homologues of p-STAG2 [chromosome] (Drosophila melanogaster)

Homologues of p-STAG2 [chromosome] (Schizosaccharomyces pombe)

phospho-psc3 [chromosome] (Schizosaccharomyces pombe)

phospho-stag2b [chromosome] (Danio rerio)

phospho-rec11 [chromosome] (Schizosaccharomyces pombe)

phospho-stag2 [chromosome] (Xenopus tropicalis)

phospho-STAG2 [chromosome] (Bos taurus)

phospho-STAG2 [chromosome] (Sus scrofa)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60216 RAD21	14	RAD21 [nucleoplasm] (R-HSA-163042) RAD21 [chromosome, centromeric region] (R-HSA-2466012) RAD21 [chromosome] (R-HSA-1638775) p-S454-RAD21 [chromosome, centromeric region] (R-HSA-2485163) p-S454-RAD21 [cytosol] (R-HSA-2500310) p-S454-RAD21 [chromosome] (R-HSA-2485164) RAD21(1-172) [cytosol] (R-HSA-2484901) RAD21(173-450) [cytosol] (R-HSA-2500308) p-S454-RAD21(451-631) [cytosol] (R-HSA-2500309) RAD21 [cytosol] (R-HSA-2484795) RAD21(1-172) [chromosome, centromeric region] (R-HSA-2467793) p-S454-RAD21(451-631) [chromosome, centromeric region] (R-HSA-2467790) RAD21(173-450) [chromosome, centromeric region] (R-HSA-2500296) monoSUMO1-K-RAD21 [nucleoplasm] (R-HSA-3108183)	0.967	23
UniProt:Q7Z5K2 WAPL	4	WAPAL [cytosol] (R-HSA-2484802) WAPAL [chromosome] (R-HSA-2577090) WAPAL [chromosome, centromeric region] (R-HSA-2577088) WAPAL [nucleoplasm] (R-HSA-2466355)	0.922	14
UniProt:Q5FBB7 SGO1	3	SGOL1 [cytosol] (R-HSA-376227) SGO1 [nucleoplasm] (R-HSA-2468161) p-S-SGO1 [nucleoplasm] (R-HSA-9929718)	0.774	7
UniProt:Q9CPY3	6	phospho-Cdca5 [cytosol] (R-MMU-2484804) phospho-Cdca5 [chromosome, centromeric region] (R-MMU-2468269) phospho-Cdca5 [chromosome] (R-MMU-2468266) Cdca5 [chromosome] (R-MMU-2468149) Cdca5 [chromosome, centromeric region] (R-MMU-2468260) Cdca5 [nucleoplasm] (R-MMU-2466357)	0.669	3
UniProt:Q96FF9 CDCA5	6	p-S21,S75,T159-CDCA5 [cytosol] (R-HSA-2484804) p-S21,S75,T159-CDCA5 [chromosome, centromeric region] (R-HSA-2468269) p-S21,S75,T159-CDCA5 [chromosome] (R-HSA-2468266) CDCA5 [chromosome] (R-HSA-2468149) CDCA5 [chromosome, centromeric region] (R-HSA-2468260) CDCA5 [nucleoplasm] (R-HSA-2466357)	0.643	5
UniProt:Q9NP77 SSU72	1	SSU72 [nucleoplasm] (R-HSA-6814915)	0.577	4
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.539	3

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