Reactome | NDUFB11 [mitochondrial inner membrane]

NDUFB11 [mitochondrial inner membrane]

Stable Identifier

R-HSA-163933

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

NADH-ubiquinone oxidoreductase ESSS subunit

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
    - Respiratory electron transport (Homo sapiens)
      - Complex I biogenesis (Homo sapiens)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB11 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB11 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB11 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB11 [mitochondrial inner membrane] (Homo sapiens)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB11 [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB11 [mitochondrial inner membrane] (Homo sapiens)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB11 [mitochondrial inner membrane] (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB11 [mitochondrial inner membrane] (Homo sapiens)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB11 [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB11 [mitochondrial inner membrane] (Homo sapiens)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB11 [mitochondrial inner membrane] (Homo sapiens)
        
        Complex I [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB11 [mitochondrial inner membrane] (Homo sapiens)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Homo sapiens)
        
        Complex I [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB11 [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NX14 NDUFB11

Gene Names

NDUFB11, UNQ111/PRO1064

Chain

transit peptide:1-29, chain:30-153

Reference Genes

BioGPS Gene:54539 NDUFB11

COSMIC (genes):NDUFB11 NDUFB11

CTD Gene:54539 NDUFB11

dbSNP Gene:54539 NDUFB11

ENSEMBL:ENSG00000147123 NDUFB11

HGNC:20372 NDUFB11

KEGG Gene (Homo sapiens):54539 NDUFB11

Monarch:54539 NDUFB11

NCBI Gene:54539 NDUFB11

OMIM:300403 NDUFB11

UCSC:Q9NX14 NDUFB11

Reference Transcript

Other Identifiers

11717251_s_at

11717252_x_at

17110429

218320_s_at

30367

3386460

4007010

4007011

4007013

4007014

4007017

4007018

4007019

54539

56467_s_at

5XTC

5XTD

5XTH

5XTI

8172296

A_23_P22765

AAH10665

AAI07806

AAK34953

AAL32064

AAQ89415

AF044213

AF251063

AK000501

AL513366

AY359056

BAA91208

BC010665

BC107805

CAG33520

CCDS14273

CCDS48100

CR457239

ENSG00000147123

ENSP00000276062

ENSP00000367042

ENST00000276062

ENST00000276062.8

ENST00000377811

ENST00000377811.3

EntrezGene:54539

EntrezGene:NDUFB11

g9506682_3p_s_at

GE55524

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005739

GO:0005743

GO:0005747

GO:0006091

GO:0006120

GO:0007005

GO:0008150

GO:0016020

GO:0016021

GO:0022607

GO:0032981

GO:0032991

GO:0043226

GO:0055114

GO:0065003

GO:0070469

HGNC:20372

HPA030367

ILMN_1749709

IPR019329

MIM:300403

MIM:300952

MIM:301021

MIM:309801

NDUFB11

NDUFB11-201

NDUFB11-202

NM_001135998

NM_019056

NP_001129470

NP_061929

PF10183

PH_hs_0020112

TC0X000994.hg

TC0X002052.hg

UPI0000048EEE

UPI0000072489

Participant Of

hasComponent

HP subcomplex [mitochondrial inner membrane]

Inferred To

NDUFB11 [mitochondrial inner membrane] (Bos taurus)

NDUFB11 [mitochondrial inner membrane] (Caenorhabditis elegans)

NDUFB11 [mitochondrial inner membrane] (Canis familiaris)

NDUFB11 [mitochondrial inner membrane] (Danio rerio)

NDUFB11 [mitochondrial inner membrane] (Drosophila melanogaster)

NDUFB11 [mitochondrial inner membrane] (Mus musculus)

NDUFB11 [mitochondrial inner membrane] (Rattus norvegicus)

NDUFB11 [mitochondrial inner membrane] (Sus scrofa)

Ghost homologue of NDUFB11 [mitochondrial inner membrane] (Gallus gallus)

Ghost homologue of NDUFB11 [mitochondrial inner membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001129470.1, NP_061929.2

OpenTargets

ENSG00000147123

GeneCards

Q9NX14

PRO

Q9NX14

Orphanet

23222

HMDB Protein

HMDBP01106

PDB

5XTC, 5XTH, 5XTD, 5XTI

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75489 NDUFS3	1	NDUFS3 [mitochondrial matrix] (R-HSA-163927)	0.527	4
UniProt:P08034 GJB1	2	GJB1 [endoplasmic reticulum membrane] (R-HSA-190656) GJB1 [endoplasmic reticulum-Golgi intermediate compartment] (R-HSA-190636)	0.488	2
UniProt:Q9NPL8 TIMMDC1	1	TIMMDC1 [mitochondrial inner membrane] (R-HSA-5689720)	0.488	2
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.488	2