Reactome | NDUFV2 [mitochondrial inner membrane]

NDUFV2 [mitochondrial inner membrane]

Stable Identifier

R-HSA-163939

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

NADH-ubiquinone oxidoreductase 24 kDa subunit

Locations in the PathwayBrowser for interactor UniProt:Q8IWL3

Expand all

Metabolism (Homo sapiens)

- The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
    - Respiratory electron transport (Homo sapiens)
      - Complex I biogenesis (Homo sapiens)
        
        NUBPL transfers 4Fe-4S to NDUFV1, V2 (Homo sapiens)
        
        NDUFV2 [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P19404 NDUFV2

Gene Names

NDUFV2

Chain

transit peptide:1-32, chain:33-249

Reference Genes

BioGPS Gene:4729 NDUFV2

COSMIC (genes):NDUFV2 NDUFV2

CTD Gene:4729 NDUFV2

dbSNP Gene:4729 NDUFV2

ENSEMBL:ENSG00000178127 NDUFV2

HGNC:7717 NDUFV2

KEGG Gene (Homo sapiens):4729 NDUFV2

Monarch:4729 NDUFV2

NCBI Gene:4729 NDUFV2

OMIM:600532 NDUFV2

UCSC:P19404 NDUFV2

Reference Transcript

RefSeq:NM_021074.4 NDUFV2

Other Identifiers

0005570162

11718282_s_at

16850849

202941_at

34893_at

3778208

3778209

3778225

3778226

3778228

3778229

3778231

3778234

3778237

3778246

3778247

4729

8020058

8039068

A_23_P130418

GE82585

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005743

GO:0005747

GO:0005829

GO:0006091

GO:0006120

GO:0007005

GO:0007399

GO:0008137

GO:0008150

GO:0009055

GO:0016020

GO:0016491

GO:0022607

GO:0032981

GO:0032991

GO:0043167

GO:0043226

GO:0046872

GO:0048738

GO:0048856

GO:0051536

GO:0051537

GO:0055114

GO:0065003

GO:0070469

HMNXSV003048082

ILMN_1766496

ILMN_2086417

M22538_at

PH_hs_0028904

TC18000041.hg

g10835024_3p_at

Participates

as an input of

NUBPL transfers 4Fe-4S to NDUFV1, V2 (Homo sapiens)

as a component of

NDUFV2:4Fe-4S [mitochondrial inner membrane] (Homo sapiens)

Inferred To

ND-24 [mitochondrial inner membrane] (Drosophila melanogaster)

Ghost homologue of NDUFV2 [mitochondrial inner membrane] (Canis familiaris)

Ndufv2 [mitochondrial inner membrane] (Mus musculus)

Ndufv2 [mitochondrial inner membrane] (Rattus norvegicus)

NDUFV2 [mitochondrial inner membrane] (Bos taurus)

NDUFV2 [mitochondrial inner membrane] (Caenorhabditis elegans)

NDUFV2 [mitochondrial inner membrane] (Gallus gallus)

NDUFV2 [mitochondrial inner membrane] (Sus scrofa)

ndufv2 [mitochondrial inner membrane] (Danio rerio)

ndufv2 [mitochondrial inner membrane] (Dictyostelium discoideum)

Cross References

RefSeq

NP_066552.2

Target Pathogen

5b354852be737e166372eb1c

OpenTargets

ENSG00000178127

GeneCards

P19404

HPA

ENSG00000178127-NDUFV2

Ensembl

ENST00000318388, ENSG00000178127, ENSP00000327268

PRO

P19404

Orphanet

16534

HMDB Protein

HMDBP00142

PDB

5XTD, 5XTI, 5XTB, 5XTH

Interactors (90)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75489 NDUFS3	2	NDUFS3 [cytosol] (R-HSA-9714751) NDUFS3 [mitochondrial matrix] (R-HSA-163927)	0.725	9
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.718	6
UniProt:Q16795 NDUFA9	1	NDUFA9 [mitochondrial matrix] (R-HSA-163942)	0.564	3
UniProt:Q8IWL3 HSCB	5	HSCB [mitochondrial inner membrane] (R-HSA-1299447) HSCB [mitochondrial matrix] (R-HSA-1299438) HSCB(1-235) [mitochondrial inner membrane] (R-HSA-1299443) HSCB(1-30) [mitochondrial matrix] (R-HSA-8986120) HSCB(1-235) [mitochondrial intermembrane space] (R-HSA-1299456)	0.558	6
UniProt:Q8IUI8 CRLF3			0.556	3
UniProt:Q96HD1-2 Q96HD12			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [cytosol] (R-HSA-5654207) SPRED1 [plasma membrane] (R-HSA-5658225)	0.556	3
UniProt:Q8N7B6-2 PACRGL			0.556	3
UniProt:Q7Z698 SPRED2	2	SPRED2 [plasma membrane] (R-HSA-5658229) SPRED2 [cytosol] (R-HSA-5654211)	0.556	3
IntAct:EBI-25850457 CCSB			0.556	3
UniProt:Q5T6S3 PHF19	1	PHF19 [nucleoplasm] (R-HSA-5084115)	0.556	3
UniProt:Q9Y261-2 Q9Y2612			0.556	3
IntAct:EBI-25850770 CCSB			0.556	3
UniProt:Q86V28 Q86V28			0.556	3
UniProt:Q9Y2M5 KLHL20	1	KLHL20 [cytosol] (R-HSA-976032)	0.556	3
UniProt:O15381-5 O153815			0.556	3
UniProt:Q96QF0-7 RAB3IP			0.556	3
UniProt:Q8WXF7 ATLA1			0.556	3
UniProt:Q86WT6-2 TRIM69			0.556	3
UniProt:Q9NRY5 FAM114A2	2	FAM114A2-BRAF fusion [cytosol] (R-HSA-6802321) p-FAM114A2-BRAF fusion [cytosol] (R-HSA-6802525)	0.556	3
UniProt:P17023 ZNF19	1	ZNF19 [nucleoplasm] (R-HSA-974992)	0.556	3
UniProt:Q8NBJ4 GOLM1	2	GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710) p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938)	0.556	3
UniProt:Q7L7L0 H2AW	11	Ub-HIST3H2A [nucleoplasm] (R-HSA-6782531) K63polyUb-HIST3H2A [nucleoplasm] (R-HSA-6783249) HIST3H2A [nucleoplasm] (R-HSA-4549209) MeR12-HIST3H2A [nucleoplasm] (R-HSA-5229220) Me2aR12-HIST3H2A [nucleoplasm] (R-HSA-5229302) MeR4-HIST3H2A [nucleoplasm] (R-HSA-5244613) Me2aR4-HIST3H2A [nucleoplasm] (R-HSA-5244626) MeR30-HIST3H2A [nucleoplasm] (R-HSA-5244566) Me2aR30-HIST3H2A [nucleoplasm] (R-HSA-5244532) AcK-HIST3H2A [nucleoplasm] (R-HSA-4551313) AcK6-HIST3H2A [nucleoplasm] (R-HSA-4568608)	0.556	3
UniProt:Q71DI3 H3C15	57	MeK-HIST2H3A [nucleoplasm] (R-HSA-417240) HIST2H3A [extracellular region] (R-HSA-977578) 2xAcK-HIST2H3A [nucleoplasm] (R-HSA-427525) AcK24-HIST2H3A [nucleoplasm] (R-HSA-4568747) AcK19-HIST2H3A [nucleoplasm] (R-HSA-4568750) AcK15-HIST2H3A [nucleoplasm] (R-HSA-4568755) AcK5-HIST2H3A [nucleoplasm] (R-HSA-4568752) Ack15-HIST2H3A [nucleoplasm] (R-HSA-4549224) Me2aR27-HIST2H3A [nucleoplasm] (R-HSA-5229057) MeR27-HIST2H3A [nucleoplasm] (R-HSA-5229060) Me2aR18-HIST2H3A [nucleoplasm] (R-HSA-5229063) Me2sR9-HIST2H3A [nucleoplasm] (R-HSA-5211327) Me2sR3-HIST2H3A [nucleoplasm] (R-HSA-5218930) AcK9,14-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8870892) AcK14,18,79-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8871273) AcK9,14,18-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871304) AcK14,18-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871292) AcK9,14,18,79-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8865607) AcK14,18-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8871296) AcK14,18,79-p-T11-HIST2H3A [nucleoplasm] (R-HSA-8871290) AcK14,18-p-T11-HIST2H3A [nucleoplasm] (R-HSA-8871302) AcK14,18,79-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871289) Me3K10-HIST2H3A [nucleoplasm] (R-HSA-4754191) Me3K28-HIST2H3A [nucleoplasm] (R-HSA-4754178) Me2K28-HIST2H3A [nucleoplasm] (R-HSA-4754197) Me2K10-HIST2H3A [nucleoplasm] (R-HSA-4724280) MeK37-HIST2H3A [nucleoplasm] (R-HSA-4722131) MeK80-HIST2H3A [nucleoplasm] (R-HSA-5649805) Me3K80-HIST2H3A [nucleoplasm] (R-HSA-5649798) Me2K80-HIST2H3A [nucleoplasm] (R-HSA-5649803) Me3K37-HIST2H3A [nucleoplasm] (R-HSA-5638140) Me2K37-HIST2H3A [nucleoplasm] (R-HSA-4722126) MeK10-HIST2H3A [nucleoplasm] (R-HSA-4724283) MeK28-HIST2H3A [nucleoplasm] (R-HSA-5638326) MeK10-HIST2H3A [cytosol] (R-HSA-8943828) HIST2H3A [cytosol] (R-HSA-8943831) Me2aR3-HIST2H3A [nucleoplasm] (R-HSA-5244518) MeK5-HIST2H3A [nucleoplasm] (R-HSA-4687009) Cit27-HIST2H3A [nucleoplasm] (R-HSA-5246539) Cit9-HIST2H3A [nucleoplasm] (R-HSA-5246545) Cit18-HIST2H3A [nucleoplasm] (R-HSA-5246536) MeR18-HIST2H3A [nucleoplasm] (R-HSA-5229044) MeR3-HIST2H3A [nucleoplasm] (R-HSA-5244520) MeR27-HIST2H3A [nucleoplasm] (R-HSA-5244804) MeR9-HIST2H3A [nucleoplasm] (R-HSA-5244803) Ack10-HIST2H3A [nucleoplasm] (R-HSA-4568924) Me2K5,Me2aR3-HIST2H3A [nucleoplasm] (R-HSA-8936570) Me2K-10-HIST2H3A [nucleoplasm] (R-HSA-427407) p-T12-HIST2H3A [nucleoplasm] (R-HSA-5625871) p-T12,MeK-HIST2H3A [nucleoplasm] (R-HSA-5625857) Me3K-10-HIST2H3A [nucleoplasm] (R-HSA-427744) p-T12, Me3K-10-HIST2H3A [nucleoplasm] (R-HSA-5625754) p-T12, Me2K-10-HIST2H3A [nucleoplasm] (R-HSA-5625792) Me3K5-HIST2H3A [nucleoplasm] (R-HSA-1214223) HIST2H3A [nucleoplasm] (R-HSA-212281) Me3K-28-HIST2H3A [nucleoplasm] (R-HSA-212253) Me2K5-HIST2H3A [nucleoplasm] (R-HSA-1214225)	0.556	3
UniProt:Q9GZS3 WDR61	2	WDR61 [nucleoplasm] (R-HSA-8866696) WDR61 [cytosol] (R-HSA-8931534)	0.556	3
UniProt:P0DP25 CALM			0.556	3
UniProt:Q8N6F8 MET27			0.556	3
UniProt:Q9NVV9 THAP1			0.556	3
UniProt:Q9Y3D2 MSRB2	1	MSRB2 [cytosol] (R-HSA-5676906)	0.556	3
UniProt:Q96D59 RN183			0.556	3
UniProt:Q96FT7-4 ASIC4			0.556	3
UniProt:Q96I34 PP16A			0.556	3
UniProt:Q8IUW3 SPA2L			0.556	3
UniProt:P43356 MAGA2			0.556	3
UniProt:Q8WWW0-2 RASSF5			0.556	3
UniProt:Q92613 JADE3	1	PHF16 [nucleoplasm] (R-HSA-3321851)	0.556	3
UniProt:Q8N0Y2-2 ZNF444			0.556	3
UniProt:Q9UNY5 ZN232			0.556	3
UniProt:Q5T2W1 NHRF3			0.556	3
UniProt:P57052 RBM11			0.556	3
UniProt:Q8NHS9 SPT22			0.556	3
UniProt:Q99457 NP1L3			0.556	3
UniProt:P58304 VSX2			0.556	3
UniProt:Q96PV6 LENG8			0.556	3
UniProt:Q9NS23-4 RASSF1			0.556	6
UniProt:O75436 VPS26A	1	VPS26A [cytosol] (R-HSA-3247739)	0.556	3
UniProt:Q9NZC7-5 WWOX			0.556	3
UniProt:Q9BZZ5-2 API5			0.556	3
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.556	3
UniProt:P20042 EIF2S2	1	EIF2S2 [cytosol] (R-HSA-72512)	0.556	3
UniProt:Q5VYS8-5 TUT7			0.556	3
UniProt:P63010-2 AP2B1			0.556	3
UniProt:Q86VK4-3 ZNF410			0.556	3
UniProt:Q9Y575-3 ASB3			0.556	3
UniProt:Q96FW1 OTUB1	2	OTUB1 [nucleoplasm] (R-HSA-6783242) OTUB1 [cytosol] (R-HSA-933411)	0.556	3
UniProt:Q6ZMI0-5 PPP1R21			0.556	3
UniProt:Q16549 PCSK7			0.556	3
UniProt:Q14525 KRT33B	1	KRT33B [cytosol] (R-HSA-6809594)	0.556	3
UniProt:Q8N6K7-2 SAMD3			0.556	3
UniProt:Q6GQQ9-2 Q6GQQ92			0.556	3
UniProt:Q6AZY7-2 Q6AZY72			0.556	3
IntAct:EBI-25831465 CCSB			0.556	3
UniProt:Q9ULX5 RN112			0.556	3
UniProt:P10073 ZSC22			0.556	3
UniProt:P32242 OTX1			0.556	3
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q9BR01-2 Q9BR012			0.556	3
UniProt:Q96GM5 SMARCD1	1	SMARCD1 [nucleoplasm] (R-HSA-389255)	0.556	3
UniProt:Q6X4W1-6 NSMF			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q86UV6-2 TRIM74			0.556	3
UniProt:Q8WUW1 BRK1	1	BRK1 [cytosol] (R-HSA-1671645)	0.556	3
UniProt:Q9BRX9 WDR83	1	WDR83 [endosome membrane] (R-HSA-5672942)	0.556	3
UniProt:P57729 RAB38	3	GGC-RAB38 [cytosol] (R-HSA-8873999) GGC-RAB38 [melanosome membrane] (R-HSA-8877740) RAB38 [cytosol] (R-HSA-8873711)	0.556	3
UniProt:O95391 SLU7	1	hSLU7 [nucleoplasm] (R-HSA-72073)	0.556	3
UniProt:P10599 TXN	4	TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [nucleoplasm] (R-HSA-9617733) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [cytosol] (R-HSA-66000)	0.556	3
UniProt:Q16625 OCLN	4	OCLN(1-320) [plasma membrane] (R-HSA-351854) OCLN [cell junction] (R-HSA-2160944) OCLN(321-522) [plasma membrane] (R-HSA-351873) OCLN [plasma membrane] (R-HSA-351846)	0.556	3
UniProt:P07437 TUBB	3	TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [cytosol] (R-HSA-9020816) TUBB [extracellular region] (R-HSA-380317)	0.556	3
UniProt:O15287 FANCG	1	FANCG [nucleoplasm] (R-HSA-419532)	0.556	3
UniProt:P35222 CTNNB1	33	CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) Ub-K,p-Y-CTNNB1 [cytosol] (R-HSA-8877006) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1 [nucleoplasm] (R-HSA-3451168)	0.556	3
UniProt:Q92673 SORL1	2	SORL1 [Golgi membrane] (R-HSA-8871510) SORL1 [endosome membrane] (R-HSA-8871475)	0.556	3
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) SUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.556	3
UniProt:Q9UNS2 COPS3	2	COPS3 [cytosol] (R-HSA-416973) COPS3 [nucleoplasm] (R-HSA-5697017)	0.556	3
UniProt:P06241-3 FYN			0.556	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3
UniProt:Q96EY1-3 DNAJA3			0.556	3
UniProt:Q6DKI2 LEG9C			0.556	3
UniProt:Q6P1J6-2 PLB1			0.556	3
UniProt:O75306 NDUFS2	1	NDUFS2 [mitochondrial matrix] (R-HSA-6788520)	0.527	2
UniProt:O75380 NDUFS6	1	NDUFS6 [mitochondrial inner membrane] (R-HSA-163922)	0.527	2

Cite Us!