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PRKAB2 [nucleoplasm]
Stable Identifier
R-HSA-164096
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
AMPK beta2
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
AMPK phosphorylates TP53 (Homo sapiens)
Activated AMPK heterotrimer [nucleoplasm] (Homo sapiens)
AMPK beta [nucleoplasm] (Homo sapiens)
PRKAB2 [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
AMPK inhibits chREBP transcriptional activation activity (Homo sapiens)
AMP binds to gamma subunit of AMP kinase heterotrimer (Homo sapiens)
AMPK heterotrimer (inactive) [nucleoplasm] (Homo sapiens)
PRKAB2 [nucleoplasm] (Homo sapiens)
AMPK heterotrimer:AMP [nucleoplasm] (Homo sapiens)
PRKAB2 [nucleoplasm] (Homo sapiens)
LKB1 phosphorylates the alpha subunit of AMPK heterotrimer (Homo sapiens)
AMPK heterotrimer:AMP [nucleoplasm] (Homo sapiens)
PRKAB2 [nucleoplasm] (Homo sapiens)
Activated AMPK heterotrimer [nucleoplasm] (Homo sapiens)
PRKAB2 [nucleoplasm] (Homo sapiens)
Phosphorylation of ChREBP at Serine 556 by AMPK (Homo sapiens)
Activated AMPK heterotrimer [nucleoplasm] (Homo sapiens)
PRKAB2 [nucleoplasm] (Homo sapiens)
Organelle biogenesis and maintenance (Homo sapiens)
Mitochondrial biogenesis (Homo sapiens)
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (Homo sapiens)
AMPK phosphorylates PPARGC1A (Homo sapiens)
p-AMPK heterotrimer:AMP [nucleoplasm] (Homo sapiens)
p-AMPK heterotrimer [nucleoplasm] (Homo sapiens)
AMPK beta [nucleoplasm] (Homo sapiens)
PRKAB2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43741 PRKAB2
Gene Names
PRKAB2
Chain
chain:1-272
Reference Genes
BioGPS Gene:5565 PRKAB2
COSMIC (genes):PRKAB2 PRKAB2
CTD Gene:5565 PRKAB2
dbSNP Gene:5565 PRKAB2
ENSEMBL:ENSG00000131791 PRKAB2
HGNC:9379 PRKAB2
KEGG:hsa:5565 PRKAB2
Monarch:5565 PRKAB2
NCBI Gene:5565 PRKAB2
OMIM:602741 PRKAB2
UCSC:O43741 PRKAB2
Reference Transcript
RefSeq:NM_005399.4 PRKAB2
Other Identifiers
11718956_a_at
11718957_at
11718958_s_at
1558027_PM_s_at
1558027_s_at
16692297
214474_PM_at
214474_at
225278_PM_at
225278_at
2433210
2433211
2433212
2433213
2433215
2433216
2433217
2433218
2433219
2433220
2433221
2433224
2433225
36705_at
51254_at
5565
78707_at
7919305
A_23_P350704
A_24_P105564
A_24_P917711
GE55250
GO:0003824
GO:0004679
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006629
GO:0006633
GO:0007165
GO:0016740
GO:0019901
GO:0031588
GO:0031669
GO:0043226
GO:0120162
GO:0140096
HMNXSV003016384
Hs.35304.0.S1_3p_at
Hs.50732.0.S1_3p_at
Hs2.399853.1.S1_3p_s_at
ILMN_1786021
PH_hs_0003495
TC01003124.hg
Participates
as a component of
Activated AMPK heterotrimer [nucleoplasm] (Homo sapiens)
AMPK heterotrimer:AMP [nucleoplasm] (Homo sapiens)
AMPK heterotrimer (inactive) [nucleoplasm] (Homo sapiens)
as a member of
AMPK beta [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PRKAB2 [cytosol]
Inferred To
CRP1 [nucleoplasm]
(Saccharomyces cerevisiae)
aakb-1 [nucleoplasm]
(Caenorhabditis elegans)
prkab [nucleoplasm]
(Dictyostelium discoideum)
SIP2 [nucleoplasm]
(Saccharomyces cerevisiae)
aakb-2 [nucleoplasm]
(Caenorhabditis elegans)
PRKAB2 [nucleoplasm]
(Bos taurus)
PRKAB2 [nucleoplasm]
(Canis familiaris)
PRKAB2 [nucleoplasm]
(Gallus gallus)
PRKAB2 [nucleoplasm]
(Schizosaccharomyces pombe)
PRKAB2 [nucleoplasm]
(Sus scrofa)
Prkab2 [nucleoplasm]
(Mus musculus)
Prkab2 [nucleoplasm]
(Rattus norvegicus)
GAL83 [nucleoplasm]
(Saccharomyces cerevisiae)
MDG1 [nucleoplasm]
(Saccharomyces cerevisiae)
SIP1 [nucleoplasm]
(Saccharomyces cerevisiae)
alc [nucleoplasm]
(Drosophila melanogaster)
Homologues of PRKAB2 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of PRKAB2 [nucleoplasm]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_005390.1
Guide to Pharmacology - Targets
1544
OpenTargets
ENSG00000131791
ENSEMBL
ENST00000254101
,
ENSP00000254101
HPA
ENSG00000131791-PRKAB2
PRO
O43741
Pharos - Targets
O43741
PDB
2V8Q
,
2V9J
,
2Y8L
,
4EAJ
,
4CFH
,
4EAI
,
4RER
,
2YA3
,
4REW
,
2Y8Q
,
7JHG
,
2F15
,
7JHH
,
7M74
,
6B2E
,
2V92
,
7JIJ
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.933
17
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.879
10
UniProt:Q9UIH9 KLF15
1
KLF15 [nucleoplasm]
(R-HSA-8878735)
0.87
9
UniProt:P61289 PSME3
1
PSME3 [cytosol]
(R-HSA-68816)
0.841
9
UniProt:Q12933 TRAF2
5
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
0.83
8
UniProt:Q9Y5V3 MAGED1
1
MAGED1 [cytosol]
(R-HSA-196002)
0.666
4
UniProt:Q9GZV8 PRDM14
1
PRDM14 [nucleoplasm]
(R-HSA-1112608)
0.666
4
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.666
4
UniProt:O43597 SPRY2
8
p-S112,S115-SPRY2 [cytosol]
(R-HSA-1295619)
SPRY2 [cytosol]
(R-HSA-182949)
SPRY2 [plasma membrane]
(R-HSA-182924)
p-S112,S121-SPRY2 [plasma membrane]
(R-HSA-934595)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-934555)
p-S111,S120-SPRY2 [cytosol]
(R-HSA-1295590)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-1295629)
p-Y55-SPRY2 [cytosol]
(R-HSA-182950)
0.666
4
UniProt:Q15742 NAB2
1
NAB2 [nucleoplasm]
(R-HSA-9612177)
0.556
3
UniProt:O75928 PIAS2
1
PIAS2 [nucleoplasm]
(R-HSA-2993787)
0.556
3
UniProt:O00231 PSMD11
5
PSMD11 [cytosol]
(R-HSA-68790)
PSMD11 [nucleoplasm]
(R-HSA-174327)
PSMD11 [secretory granule lumen]
(R-HSA-6800943)
PSMD11 [extracellular region]
(R-HSA-6806441)
PSMD11 [ficolin-1-rich granule lumen]
(R-HSA-6800436)
0.556
3
UniProt:Q8N9N5 BANP
1
BANP [nucleoplasm]
(R-HSA-3221973)
0.556
3
UniProt:P42575 CASP2
3
CASP2(170-325) [cytosol]
(R-HSA-2976746)
CASP2(348-452) [cytosol]
(R-HSA-2976745)
CASP2(2-452) [cytosol]
(R-HSA-622412)
0.556
3
UniProt:Q01974 ROR2
2
ROR2 [plasma membrane]
(R-HSA-197731)
ROR2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5140729)
0.556
3
UniProt:Q8TDS5 OXER1
1
OXER1 [plasma membrane]
(R-HSA-416425)
0.556
3
UniProt:Q14957 GRIN2C
3
GRIN2C [plasma membrane]
(R-HSA-419560)
GRIN2C [endoplasmic reticulum membrane]
(R-HSA-9609761)
p-Y-GRIN2C [plasma membrane]
(R-HSA-9612189)
0.556
3
UniProt:Q96RU7 TRIB3
3
TRIB3 [plasma membrane]
(R-HSA-199447)
TRIB3 [cytosol]
(R-HSA-162411)
TRIB3 [nucleoplasm]
(R-HSA-9635877)
0.556
3
UniProt:P01185 AVP
10
AVP(20-28) [extracellular region]
(R-HSA-388474)
AVP(20-28) [cytosol]
(R-HSA-879509)
AVP E47del [extracellular region]
(R-HSA-5621396)
AVP P7L [extracellular region]
(R-HSA-5621460)
AVP C67* [extracellular region]
(R-HSA-5621431)
AVP V67A [extracellular region]
(R-HSA-5621446)
AVP A1T [extracellular region]
(R-HSA-5621473)
AVP Y2H [extracellular region]
(R-HSA-5621449)
AVP G23R [extracellular region]
(R-HSA-5621464)
AVP(20-28) [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869075)
0.556
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:Q9NZH6 IL37
6
IL37(?-218) [extracellular region]
(R-HSA-9008607)
IL37 [extracellular region]
(R-HSA-8848334)
IL37(?-218) [cytosol]
(R-HSA-9008584)
IL37 [cytosol]
(R-HSA-9008596)
IL37(1-?) [cytosol]
(R-HSA-9008602)
IL37(?-218) [nucleoplasm]
(R-HSA-9008702)
0.556
5
UniProt:P06396 GSN
7
GSN [cytosol]
(R-HSA-350275)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(200-270) [extracellular region]
(R-HSA-976940)
0.556
3
UniProt:Q07820 MCL1
1
MCL1 [cytosol]
(R-HSA-5661490)
0.527
2
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.488
2
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.488
2
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