Reactome | UQCRFS1(79-274) [mitochondrial inner membrane]

UQCRFS1(79-274) [mitochondrial inner membrane]

Stable Identifier

R-HSA-164278

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Rieske protein subunit pf complex III

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Aerobic respiration and respiratory electron transport (Homo sapiens)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
    - Respiratory electron transport (Homo sapiens)
      - Electron transfer from ubiquinol to cytochrome c of complex III (Homo sapiens)
        
        Ubiquinol-cytochrome c reductase [mitochondrial inner membrane] (Homo sapiens)
        
        Complex III - Rieske protein-2Fe-2S cluster complex [mitochondrial inner membrane] (Homo sapiens)
        
        UQCRFS1(79-274) [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P47985 UQCRFS1

Gene Names

UQCRFS1

Chain

chain:1-78, chain:79-274

Reference Genes

BioGPS Gene:7386 UQCRFS1

COSMIC (genes):UQCRFS1 UQCRFS1

CTD Gene:7386 UQCRFS1

dbSNP Gene:7386 UQCRFS1

ENSEMBL:ENSG00000169021 UQCRFS1

ENSEMBL_homo_sapiens_GENE:ENSG00000169021.6 UQCRFS1

HGNC:12587 UQCRFS1

KEGG Gene (Homo sapiens):7386 UQCRFS1

Monarch:7386 UQCRFS1

NCBI Gene:7386 UQCRFS1

OMIM:191327 UQCRFS1

UCSC:P47985 UQCRFS1

Reference Transcript

RefSeq:NM_006003.2 UQCRFS1

Other Identifiers

11757847_s_at

16871051

208909_PM_at

208909_at

34401_at

3857690

3857692

3857693

3857694

3857695

3857696

3857699

3946089

3946091

3946093

3946094

71020_at

7386

8035880

8073192

A_23_P153586

GE60494

GE840777

GO:0003824

GO:0005215

GO:0005515

GO:0005739

GO:0005743

GO:0005750

GO:0005751

GO:0006091

GO:0006122

GO:0007005

GO:0008121

GO:0016020

GO:0016491

GO:0022904

GO:0034551

GO:0043226

GO:0046872

GO:0051536

GO:0051537

GO:0055085

GO:0065003

GO:0070469

GO:1902600

HMNXSV003008829

ILMN_1701749

L32977_at

PH_hs_0027398

TC19001379.hg

g12653726_3p_at

Participates

as a component of

Complex III - Rieske protein-2Fe-2S cluster complex [mitochondrial inner membrane] (Homo sapiens)

Inferred To

isp-1 [mitochondrial inner membrane] (Caenorhabditis elegans)

UQCRFS1(79-274) [mitochondrial inner membrane] (Bos taurus)

UQCRFS1(79-274) [mitochondrial inner membrane] (Gallus gallus)

UQCRFS1(79-274) [mitochondrial inner membrane] (Mus musculus)

UQCRFS1(79-274) [mitochondrial inner membrane] (Rattus norvegicus)

UQCRFS1(79-274) [mitochondrial inner membrane] (Saccharomyces cerevisiae)

UQCRFS1(79-274) [mitochondrial inner membrane] (Schizosaccharomyces pombe)

ucr [mitochondrial inner membrane] (Dictyostelium discoideum)

fb78f10 [mitochondrial inner membrane] (Danio rerio)

UQCRFS1 [mitochondrial inner membrane] (Sus scrofa)

RFeSP [mitochondrial inner membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_005994.2

OpenTargets

ENSG00000169021

HPA

ENSG00000169021-UQCRFS1

GeneCards

P47985

Ensembl

ENST00000304863, ENSG00000169021, ENSP00000306397

PRO

P47985

Pharos - Targets

P47985

Orphanet

25022

HMDB Protein

HMDBP00990

PDB

5XTI, 5XTE, 5XTH

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IWL3 HSCB	5	HSCB [mitochondrial matrix] (R-HSA-1299438) HSCB [mitochondrial inner membrane] (R-HSA-1299447) HSCB(1-235) [mitochondrial inner membrane] (R-HSA-1299443) HSCB(1-30) [mitochondrial matrix] (R-HSA-8986120) HSCB(1-235) [mitochondrial intermembrane space] (R-HSA-1299456)	0.462	6
UniProt:Q9H1K1 ISCU	1	ISCU [cytosol] (R-HSA-9771680)	0.462	4
UniProt:P38646 HSPA9	6	HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993) HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964)	0.462	4

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