Reactome | UQCRB [mitochondrial inner membrane]

UQCRB [mitochondrial inner membrane]

Stable Identifier

R-HSA-164287

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Ubiquinol-cytochrome c reductase complex 14 kDa protein, Complex III subunit VI

Locations in the PathwayBrowser for interactor UniProt:Q13352 ITGB3BP

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External Reference Information

External Reference

UniProt:P14927 UQCRB

Gene Names

UQCRB, UQBP

Chain

initiator methionine:, chain:2-111

Reference Genes

BioGPS Gene:7381 UQCRB

COSMIC (genes):UQCRB UQCRB

CTD Gene:7381 UQCRB

dbSNP Gene:7381 UQCRB

ENSEMBL:ENSG00000156467 UQCRB

HGNC:12582 UQCRB

KEGG:hsa:7381 UQCRB

Monarch:7381 UQCRB

NCBI Gene:7381 UQCRB

OMIM:191330 UQCRB

UCSC:P14927 UQCRB

Reference Transcript

Other Identifiers

11716469_x_at

11716470_at

11751680_a_at

11762275_x_at

205849_PM_s_at

205849_s_at

209065_PM_at

209065_at

209066_PM_x_at

209066_x_at

244293_PM_at

244293_at

3145559

3145561

3145563

3145565

3145566

3145568

3145569

3145570

3145571

3145572

3145573

3145574

3145575

3145576

3145577

3145578

3145579

3145580

3145581

3145582

3145583

39427_at

4010095

50062_at

7381

8151909

84064_at

A_23_P31671

A_33_P3299882

GE57868

GO:0005515

GO:0005739

GO:0005743

GO:0005750

GO:0006091

GO:0006119

GO:0006122

GO:0009060

GO:0043226

GO:0045275

GO:0045333

GO:0098803

HMNXSV003017470

HMNXSV003031441

Hs.134946.0.A1_3p_at

ILMN_2128489

M22348_s_at

M26730_s_at

PH_hs_0007771

PH_hs_0037944

PH_hs_0038425

TC08001450.hg

g13528857_3p_at

g190803_3p_a_at

Participates

as an input of

Intermediate I binds second heme, UQCRB, UQCRQ (Homo sapiens)

as a component of

Inferred To

QCR7 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

UQCRB [mitochondrial inner membrane] (Bos taurus)

UQCRB [mitochondrial inner membrane] (Caenorhabditis elegans)

UQCRB [mitochondrial inner membrane] (Dictyostelium discoideum)

UQCRB [mitochondrial inner membrane] (Gallus gallus)

UQCRB [mitochondrial inner membrane] (Sus scrofa)

Uqcrb [mitochondrial inner membrane] (Mus musculus)

Uqcrb [mitochondrial inner membrane] (Rattus norvegicus)

UQCR-14 [mitochondrial inner membrane] (Drosophila melanogaster)

qcr7 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

uqcrb [mitochondrial inner membrane] (Danio rerio)

Cross References

OpenTargets

ENSG00000156467

ENSEMBL

ENSP00000287022, ENSP00000430494, ENST00000518406, ENST00000287022

HPA

ENSG00000156467-UQCRB

ZINC - Substances

QCR7_HUMAN

ZINC target

P14927

PRO

P14927

Pharos - Targets

P14927

Orphanet

UQCRB

GlyGen

P14927

ZINC - Predictions - Purchasable

QCR7_HUMAN

HMDB Protein

HMDBP00988

PDB

5XTH, 5XTI, 5XTE

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P43358 MAGA4			0.801	7
UniProt:P31930 UQCRC1	1	UQCRC1 [mitochondrial inner membrane] (R-HSA-164284)	0.669	5
UniProt:P08574 CYC1	3	CYC1(1-325) [mitochondrial intermembrane space] (R-HSA-1267962) CYC1(1-325) [cytosol] (R-HSA-1267995) CYC1 [mitochondrial inner membrane] (R-HSA-164277)	0.641	3
UniProt:Q14457 BECN1	4	BECN1 [cytosol] (R-HSA-1632841) p-S15-BECN1 [cytosol] (R-HSA-5682391) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.556	3
UniProt:Q13352 ITGB3BP	2	ITGB3BP [nucleoplasm] (R-HSA-606325) ITGB3BP [cytosol] (R-HSA-3006405)	0.556	3
UniProt:Q9BRX5 GINS3	1	GINS3 [nucleoplasm] (R-HSA-5688046)	0.556	3
UniProt:Q15027 ACAP1			0.556	3
UniProt:Q92615 LAR4B			0.556	3
UniProt:P06241-3 FYN			0.556	3
UniProt:Q1RN33 Q1RN33			0.556	3
UniProt:O15481 MAGB4			0.556	3
UniProt:Q96QU6 1A1L1			0.556	3
UniProt:Q86TI2-2 Q86TI22			0.556	3
UniProt:Q15012 LAP4A			0.556	3
UniProt:A1A512 A1A512			0.556	3
UniProt:Q19AV6 ZSWM7			0.556	3
UniProt:P84074 HPCA			0.556	3
UniProt:Q8WTV1 THAP3			0.556	3
UniProt:Q96T88 UHRF1	2	UHRF1 [nucleoplasm] (R-HSA-212103) UHRF1 [cytosol] (R-HSA-9818452)	0.527	2
UniProt:P07919 UQCRH	1	UQCRH [mitochondrial inner membrane] (R-HSA-164286)	0.527	3
UniProt:P22695 UQCRC2	1	UQCRC2 [mitochondrial inner membrane] (R-HSA-164280)	0.527	3
UniProt:O14949 UQCRQ	1	UQCRQ [mitochondrial inner membrane] (R-HSA-164283)	0.527	3
UniProt:O14548 COX7A2L	1	COX7A2L [mitochondrial inner membrane] (R-HSA-164310)	0.527	3
UniProt:P60903 S100A10	1	S100A10 [external side of plasma membrane] (R-HSA-5336168)	0.527	2
UniProt:P00156 MT-CYB	1	MT-CYB [mitochondrial inner membrane] (R-HSA-164281)	0.527	3

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