Reactome | COX5B [mitochondrial inner membrane]

COX5B [mitochondrial inner membrane]

Stable Identifier

R-HSA-164307

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Cytochrome c oxidase polypeptide Vb

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX5B:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
        
        COX5B [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX5B:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
        
        COX5B [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P10606 COX5B

Gene Names

COX5B

Chain

transit peptide:1-31, chain:32-129

Reference Genes

BioGPS Gene:1329 COX5B

COSMIC (genes):COX5B COX5B

CTD Gene:1329 COX5B

dbSNP Gene:1329 COX5B

ENSEMBL:ENSG00000135940 COX5B

HGNC:2269 COX5B

KEGG:hsa:1329 COX5B

Monarch:1329 COX5B

NCBI Gene:1329 COX5B

OMIM:123866 COX5B

UCSC:P10606 COX5B

Reference Transcript

RefSeq:NM_001862.2 COX5B

Other Identifiers

11718764_at

1329

16883205

202343_PM_x_at

202343_x_at

211025_PM_x_at

211025_x_at

213735_PM_s_at

213735_s_at

2495123

2495124

2495125

2495126

2495127

2495128

2495129

2495130

2495131

2495132

2495133

2495134

2495135

2495136

39443_s_at

39921_at

8043718

A_14_P105717

A_14_P201068

A_23_P51069

A_33_P3274851

GE81079

GE85270

GO:0004129

GO:0005515

GO:0005739

GO:0005740

GO:0005743

GO:0006091

GO:0006119

GO:0006123

GO:0007585

GO:0016020

GO:0016491

GO:0031966

GO:0045277

GO:0045333

GO:0046872

GO:0055085

GO:1902600

HMNXSV003042250

Hs.1342.1.S1_3p_s_at

ILMN_1663512

ILMN_1894862

M19961_at

PH_hs_0028697

TC02000592.hg

Participates

as a member of

Substrate of LONP1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)

as a component of

COX5B:Zn2+ [mitochondrial inner membrane] (Homo sapiens)

Inferred To

cox5ba [mitochondrial inner membrane] (Danio rerio)

cxeA [mitochondrial inner membrane] (Dictyostelium discoideum)

COX4 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

COX5B [mitochondrial inner membrane] (Bos taurus)

COX5B [mitochondrial inner membrane] (Canis familiaris)

COX5B [mitochondrial inner membrane] (Drosophila melanogaster)

COX5B [mitochondrial inner membrane] (Gallus gallus)

COX5B [mitochondrial inner membrane] (Sus scrofa)

cox5b [mitochondrial inner membrane] (Xenopus tropicalis)

cox4 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

cox-5b [mitochondrial inner membrane] (Caenorhabditis elegans)

Cox5b [mitochondrial inner membrane] (Mus musculus)

Cox5b [mitochondrial inner membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001853.2

ENSEMBL

ENST00000708077, ENSG00000135940, ENSP00000517083, ENST00000258424, ENSP00000258424, ENSG00000291596

OpenTargets

ENSG00000135940

GeneCards

COX5B

HPA

ENSG00000135940-COX5B

PRO

P10606

Pharos - Targets

P10606

HMDB Protein

HMDBP03170

PDB

5Z62

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	7
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.666	5
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.666	4
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q9BXU0 TEX12	1	TEX12 [nucleoplasm] (R-HSA-912441)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:P15954 COX7C	1	COX7C [mitochondrial inner membrane] (R-HSA-164306)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.527	4
UniProt:P11182 DBT	11	Lipo-K105-DBT [mitochondrial matrix] (R-HSA-70017) Isobutyryl-lipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859151) Isovaleryl-lipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859144) 2-Methylbutyryl-lipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859145) LipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859167) DBT [mitochondrial matrix] (R-HSA-6792584) P276C Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865046) S399C Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865036) K313_Y338del Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865051) I98M Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865057) DBT [cytosol] (R-HSA-9714663)	0.527	2