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MT-CO1 [mitochondrial inner membrane]
Stable Identifier
R-HSA-164314
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Cytoprotection by HMOX1 (Homo sapiens)
CO binds to Cytochrome c oxidase (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
MT-CO1 [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
MT-CO1 [mitochondrial inner membrane] (Homo sapiens)
Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
MT-CO1 [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
MT-CO1 [mitochondrial inner membrane] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
MT-CO1 [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
MT-CO1 [mitochondrial inner membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
MT-CO1 [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
MT-CO1 [mitochondrial inner membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Mitochondrial protein degradation (Homo sapiens)
AFG3L2 binds mitochondrial inner membrane proteins (Homo sapiens)
AFG3L2:substrate protein (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
Substrate of AFG3L2 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
MT-CO1 [mitochondrial inner membrane] (Homo sapiens)
Substrate of AFG3L2 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
MT-CO1 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 degrades mitochondrial inner membrane proteins (Homo sapiens)
AFG3L2:substrate protein (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
Substrate of AFG3L2 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
MT-CO1 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00395 MT-CO1
Gene Names
MT-CO1, COI, COXI, MTCO1
Chain
chain:1-513
Reference Genes
BioGPS Gene:4512 MT-CO1
COSMIC (genes):MT-CO1 MT-CO1
CTD Gene:4512 MT-CO1
dbSNP Gene:4512 MT-CO1
ENSEMBL:ENSG00000198804 MT-CO1
ENSEMBL_homo_sapiens_GENE:ENSG00000198804.2 MT-CO1
HGNC:7419 MT-CO1
KEGG Gene (Homo sapiens):4512 MT-CO1
Monarch:4512 MT-CO1
NCBI Gene:4512 MT-CO1
OMIM:516030 MT-CO1
Reference Transcript
RefSeq:NC_012920.1 MT-CO1
Other Identifiers
11758423_s_at
11762992_at
1553538_PM_s_at
1553538_s_at
1553567_3p_s_at
1553567_PM_s_at
1553567_s_at
1553569_PM_at
1553569_at
1553570_PM_x_at
1553570_x_at
17100657
17100659
17100661
17100663
17126266
17126268
2315227
2315229
2315230
2315231
2315232
2315316
2315317
2315318
2315319
2492706
2492708
2552564
2868799
3560048
3727290
3990047
4037616
4037618
4037620
4037622
4037624
4037625
4037626
4037627
4037628
4037629
4037631
4037633
4037634
4037635
4037637
4037639
4037640
4037641
4037642
4037643
4037644
4512
7896750
7896752
8043375
8113356
8165661
8165663
8165665
8165667
A_23_P301925
A_23_P337726
A_23_P402751
A_33_P3410700
GO:0001666
GO:0003824
GO:0004129
GO:0005215
GO:0005515
GO:0005739
GO:0005743
GO:0005750
GO:0005751
GO:0006091
GO:0006119
GO:0006123
GO:0006979
GO:0009060
GO:0015990
GO:0016020
GO:0016491
GO:0020037
GO:0021549
GO:0022900
GO:0031966
GO:0043226
GO:0045277
GO:0045333
GO:0046688
GO:0046872
GO:0048856
GO:0051602
GO:0055085
GO:0070469
GO:1902600
HMNXSV003022003
HMNXSV003032141
HMNXSV003039026
HMNXSV003041642
Hs2Affx.1.24.S1_3p_x_at
Hs2Affx.1.41.S1_3p_s_at
Hs2Affx.1.43.S1_3p_x_at
PH_hs_0033947
PH_hs_0036541
RNA143496|tRNA_413_70
RNA143539|tRNA_456_68
TC01000013.hg
TC01004110.hg
TC0M000004.hg
TC0M000005.hg
TC0M000021.hg
TC0M000022.hg
p26926
Participates
as a member of
Substrate of AFG3L2 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
as a component of
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
Inferred To
mt-co1 [mitochondrial inner membrane]
(Xenopus tropicalis)
COX1 [mitochondrial inner membrane]
(Bos taurus)
Ghost homologue of MT-CO1 [mitochondrial inner membrane]
(Canis familiaris)
MT-CO1 [mitochondrial inner membrane]
(Caenorhabditis elegans)
MT-CO1 [mitochondrial inner membrane]
(Danio rerio)
MT-CO1 [mitochondrial inner membrane]
(Dictyostelium discoideum)
MT-CO1 [mitochondrial inner membrane]
(Drosophila melanogaster)
MT-CO1 [mitochondrial inner membrane]
(Gallus gallus)
MT-CO1 [mitochondrial inner membrane]
(Mus musculus)
MT-CO1 [mitochondrial inner membrane]
(Rattus norvegicus)
MT-CO1 [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
MT-CO1 [mitochondrial inner membrane]
(Schizosaccharomyces pombe)
MT-CO1 [mitochondrial inner membrane]
(Sus scrofa)
Cross References
RefSeq
YP_003024028.1
OpenTargets
ENSG00000198804
ZINC - Substances
COX1_HUMAN
ZINC target
P00395
PRO
P00395
PDB
5Z62
GeneCards
P00395
HPA
ENSG00000198804-MT-CO1
Ensembl
ENSP00000354499
,
ENST00000361624
,
ENSG00000198804
Pharos - Targets
P00395
Orphanet
16471
ZINC - Predictions - Purchasable
COX1_HUMAN
HMDB Protein
HMDBP01630
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