Reactome | nascent MT-CO1 [mitochondrial inner membrane]

nascent MT-CO1 [mitochondrial inner membrane]

Stable Identifier

R-HSA-164314

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

COX1, Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - Cytoprotection by HMOX1 (Homo sapiens)
      - CO binds to Cytochrome c oxidase (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
        
        nascent MT-CO1 [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
        
        nascent MT-CO1 [mitochondrial inner membrane] (Homo sapiens)
      - Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
        
        nascent MT-CO1 [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
        
        nascent MT-CO1 [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
        
        nascent MT-CO1 [mitochondrial inner membrane] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
        
        nascent MT-CO1 [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
        
        nascent MT-CO1 [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
        
        nascent MT-CO1 [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P00395 MT-CO1

Gene Names

MT-CO1, COI, COXI, MTCO1

Chain

chain:1-513

Reference Genes

BioGPS Gene:4512 MT-CO1

COSMIC (genes):MT-CO1 MT-CO1

CTD Gene:4512 MT-CO1

dbSNP Gene:4512 MT-CO1

ENSEMBL:ENSG00000198804 MT-CO1

HGNC:7419 MT-CO1

KEGG:hsa:4512 MT-CO1

Monarch:4512 MT-CO1

NCBI Gene:4512 MT-CO1

OMIM:516030 MT-CO1

UCSC:P00395 MT-CO1

Reference Transcript

RefSeq:NC_012920.1 MT-CYB

Other Identifiers

11762992_at

1553538_PM_s_at

1553538_s_at

1553569_PM_at

1553569_at

1553570_PM_x_at

1553570_x_at

17100657

17100659

17100661

17100663

2315227

2315229

2315230

2315231

2315232

2315316

2315317

2492706

2552564

2868799

3560048

3727290

3990047

4037616

4037618

4037620

4037622

4037624

4037625

4037626

4037627

4037628

4037629

4037631

4037633

4037634

4037635

4037637

4037639

4512

7896750

7896752

8043375

8113356

8165661

8165663

8165665

8165667

A_23_P301925

A_23_P402751

GO:0001666

GO:0004129

GO:0005515

GO:0005739

GO:0005743

GO:0006091

GO:0006119

GO:0006123

GO:0006979

GO:0009060

GO:0016020

GO:0016491

GO:0020037

GO:0021549

GO:0022904

GO:0031966

GO:0045277

GO:0045333

GO:0046688

GO:0046872

GO:0048856

GO:0051602

GO:0055085

GO:1902600

HMNXSV003032141

HMNXSV003039026

Hs2Affx.1.24.S1_3p_x_at

Hs2Affx.1.43.S1_3p_x_at

RNA143496|tRNA_413_70

RNA143539|tRNA_456_68

TC01000013.hg

TC01004110.hg

TC0M000004.hg

TC0M000021.hg

p26926

Participates

as a member of

as an output of

MT-CO1 mRNA is translated (Homo sapiens)

as a component of

as an input of

Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL (Homo sapiens)

Inferred To

Ghost homologue of nascent MT-CO1 [mitochondrial inner membrane] (Canis familiaris)

mt-co1 [mitochondrial inner membrane] (Danio rerio)

mt-co1 [mitochondrial inner membrane] (Xenopus tropicalis)

COI [mitochondrial inner membrane] (Gallus gallus)

COX1 [mitochondrial inner membrane] (Bos taurus)

COX1 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

Mt-co1 [mitochondrial inner membrane] (Rattus norvegicus)

Mtco1 [mitochondrial inner membrane] (Mus musculus)

mt:CoI [mitochondrial inner membrane] (Drosophila melanogaster)

cox1/2 [mitochondrial inner membrane] (Dictyostelium discoideum)

cox1 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

ctc-1 [mitochondrial inner membrane] (Caenorhabditis elegans)

MT-CO1 [mitochondrial inner membrane] (Sus scrofa)

Cross References

RefSeq

YP_003024028.1

ENSEMBL

ENSG00000198804, ENSP00000354499, ENST00000361624

OpenTargets

ENSG00000198804

ZINC - Substances

COX1_HUMAN

ZINC target

P00395

PRO

P00395

GlyGen

P00395

PDB

5Z62

GeneCards

MT-CO1

HPA

ENSG00000198804-MT-CO1

Pharos - Targets

P00395

Orphanet

MT-CO1

ZINC - Predictions - Purchasable

COX1_HUMAN

HMDB Protein

HMDBP01630

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y2R0 COA3	1	COA3 [mitochondrial inner membrane] (R-HSA-9865341)	0.612	11
UniProt:P13073 COX4I1	2	COX4I1 [mitochondrial inner membrane] (R-HSA-164305) COX4I1 [mitochondrial intermembrane space] (R-HSA-9865413)	0.564	3
UniProt:Q8IVM8 S22A9			0.527	2
UniProt:Q86VR2 RETR3			0.527	2
UniProt:P07307 ASGR2	1	PALM-C54,58-ASGR2 [plasma membrane] (R-HSA-8855706)	0.527	2
UniProt:P25103 TACR1	2	TACR1 [plasma membrane] (R-HSA-380103) TACR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869122)	0.527	2
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.527	2

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