Reactome | GNB1 [plasma membrane]

GNB1 [plasma membrane]

Stable Identifier

R-HSA-164347

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

G-protein beta1 (GBB1) subunit

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P62873 GNB1

Gene Names

GNB1

Chain

initiator methionine:1, chain:2-340

Reference Genes

BioGPS Gene:2782 GNB1

COSMIC (genes):GNB1 GNB1

CTD Gene:2782 GNB1

dbSNP Gene:2782 GNB1

ENSEMBL:ENSG00000078369 GNB1

HGNC:4396 GNB1

KEGG Gene (Homo sapiens):2782 GNB1

Monarch:2782 GNB1

NCBI Gene:2782 GNB1

OMIM:139380 GNB1

UCSC:P62873 GNB1

Reference Transcript

Other Identifiers

0001580270

11717427_a_at

11717428_s_at

200744_s_at

200745_s_at

200746_s_at

2391841

2391842

2391843

2391844

2391845

2391846

2391847

2391849

2391852

2391853

2391854

2391860

2391861

2391863

2391865

2391870

2391875

2391876

2391883

2391895

2391896

2391897

2391898

2782

33341_at

7911619

A_23_P22926

A_24_P71021

GO:0001750

GO:0001917

GO:0003674

GO:0003924

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005764

GO:0005765

GO:0005773

GO:0005829

GO:0005834

GO:0005886

GO:0005929

GO:0006457

GO:0006950

GO:0007165

GO:0007186

GO:0007191

GO:0007200

GO:0007204

GO:0007213

GO:0007223

GO:0007265

GO:0007267

GO:0008092

GO:0008150

GO:0008219

GO:0008283

GO:0010659

GO:0016020

GO:0016056

GO:0019899

GO:0030168

GO:0030425

GO:0030507

GO:0032991

GO:0042592

GO:0042622

GO:0043226

GO:0044297

GO:0044877

GO:0045202

GO:0047391

GO:0048856

GO:0050877

GO:0050909

GO:0051020

GO:0060041

GO:0070062

GO:0071380

GO:0071456

GO:0071870

GO:0097381

GO:1903561

Hs.215595.0.A1_3p_s_at

Hs.215595.0.A2_3p_s_at

ILMN_1760320

M36430_s_at

PH_hs_0023640

TC01006298.hg

X04526_at

g11321584_3p_s_at

Participant Of

hasComponent

GNAL:GNB1:GNGT1 [plasma membrane]

input

G Protein trimer formation (olfactory)

hasMember

G-protein beta subunit [plasma membrane]

Other forms of this molecule

GNB1 [photoreceptor disc membrane]

Unfolded GNB1 [cytosol]

Partially folded GNB1 [cytosol]

GNB1 [cytosol]

Inferred To

gpbA [plasma membrane] (Dictyostelium discoideum)

STE4 [plasma membrane] (Saccharomyces cerevisiae)

Gbeta13F [plasma membrane] (Drosophila melanogaster)

gpb-1 [plasma membrane] (Caenorhabditis elegans)

G-protein beta 1 subunit [plasma membrane] (Mus musculus)

Gbeta76C [plasma membrane] (Drosophila melanogaster)

gnb1b [plasma membrane] (Danio rerio)

GNB1 [plasma membrane] (Bos taurus)

GNB1 [plasma membrane] (Canis familiaris)

GNB1 [plasma membrane] (Gallus gallus)

GNB1 [plasma membrane] (Sus scrofa)

GNB1 [plasma membrane] (Xenopus tropicalis)

Gnb1 [plasma membrane] (Rattus norvegicus)

Homologues of GNB1 [plasma membrane] (Drosophila melanogaster)

git5 [plasma membrane] (Schizosaccharomyces pombe)

Cross References

RefSeq

XP_016856549.1, XP_016856550.1, NP_002065.1, NP_001269468.1, XP_016856548.1, NP_001269467.1

OpenTargets

ENSG00000078369

HPA

ENSG00000078369-GNB1

GeneCards

P62873

Ensembl

ENSP00000367872, ENSG00000078369, ENST00000378609, ENST00000610897, ENSP00000481878

PRO

P62873

Orphanet

25724

HMDB Protein

HMDBP08398

PDB

6M8S, 6E3Y, 6G79, 6DDE, 6DDF, 6OT0, 6NI3, 6N4B, 5UKM, 6OIJ, 5UZ7, 5HE2, 4PNK, 6OS9, 4KFM, 6OIK, 5HE3, 6OSA, 6NIY, 5UKK, 6B3J, 6ORV, 5HE0, 6CRK, 5HE1, 6GDG, 5UKL, 6D9H, 6EG8

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P59768 GNG2	1	GNG2 [plasma membrane] (R-HSA-164380)	0.645	4
UniProt:Q08AM6 VAC14	3	VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219) VAC14 [Golgi membrane] (R-HSA-1806235)	0.556	3
UniProt:Q9UI47-2 CTNNA3			0.556	3
UniProt:Q9NRI5 DISC1			0.553	2
UniProt:P48039 MTNR1A	1	MTNR1A [plasma membrane] (R-HSA-419316)	0.527	2
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.462	3