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GNB1 [plasma membrane]
Stable Identifier
R-HSA-164347
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
G-protein beta1 (GBB1) subunit
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein activation (Homo sapiens)
The receptor:G-protein complex binds GTP (Homo sapiens)
Opioid:MOR:G-protein complex [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein [plasma membrane] (Homo sapiens)
G-protein beta subunit [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
The receptor:G-protein complex releases GDP (Homo sapiens)
Opioid:MOR:G-protein complex [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein [plasma membrane] (Homo sapiens)
G-protein beta subunit [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Olfactory Signaling Pathway (Homo sapiens)
G Protein trimer formation (olfactory) (Homo sapiens)
GNAL:GNB1:GNGT1 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
Olfactory Receptor - G Protein olfactory trimer complex formation (Homo sapiens)
GNAL:GNB1:GNGT1 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
Olfactory receptor:G protein trimer [plasma membrane] (Homo sapiens)
GNAL:GNB1:GNGT1 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62873 GNB1
Gene Names
GNB1
Chain
initiator methionine:1, chain:2-340
Reference Genes
BioGPS Gene:2782 GNB1
COSMIC (genes):GNB1 GNB1
CTD Gene:2782 GNB1
dbSNP Gene:2782 GNB1
ENSEMBL:ENSG00000078369 GNB1
HGNC:4396 GNB1
KEGG Gene (Homo sapiens):2782 GNB1
Monarch:2782 GNB1
NCBI Gene:2782 GNB1
OMIM:139380 GNB1
UCSC:P62873 GNB1
Reference Transcript
RefSeq:NM_001282538.1 GNB1
RefSeq:XM_017001060.1 GNB1
RefSeq:XM_017001059.1 GNB1
RefSeq:NM_002074.4 GNB1
RefSeq:XM_017001061.1 GNB1
RefSeq:NM_001282539.1 GNB1
Other Identifiers
0001580270
11717427_a_at
11717428_s_at
200744_s_at
200745_s_at
200746_s_at
2391841
2391842
2391843
2391844
2391845
2391846
2391847
2391849
2391852
2391853
2391854
2391860
2391861
2391863
2391865
2391870
2391875
2391876
2391883
2391895
2391896
2391897
2391898
2782
33341_at
7911619
A_23_P22926
A_24_P71021
GO:0001750
GO:0001917
GO:0003674
GO:0003924
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005764
GO:0005765
GO:0005773
GO:0005829
GO:0005834
GO:0005886
GO:0005929
GO:0006457
GO:0006950
GO:0007165
GO:0007186
GO:0007191
GO:0007200
GO:0007204
GO:0007213
GO:0007223
GO:0007265
GO:0007267
GO:0008092
GO:0008150
GO:0008219
GO:0008283
GO:0010659
GO:0016020
GO:0016056
GO:0019899
GO:0030168
GO:0030425
GO:0030507
GO:0031682
GO:0032991
GO:0042592
GO:0042622
GO:0043226
GO:0044297
GO:0044877
GO:0045202
GO:0047391
GO:0048856
GO:0050877
GO:0050909
GO:0051020
GO:0060041
GO:0070062
GO:0071380
GO:0071456
GO:0071870
GO:0097381
GO:1903561
Hs.215595.0.A1_3p_s_at
Hs.215595.0.A2_3p_s_at
ILMN_1760320
M36430_s_at
PH_hs_0023640
TC01006298.hg
X04526_at
g11321584_3p_s_at
Participant Of
input
G Protein trimer formation (olfactory)
hasComponent
GNAL:GNB1:GNGT1 [plasma membrane]
hasMember
G-protein beta subunit [plasma membrane]
Other forms of this molecule
GNB1 [photoreceptor disc membrane]
Unfolded GNB1 [cytosol]
Partially folded GNB1 [cytosol]
GNB1 [cytosol]
Inferred To
gpbA [plasma membrane] (Dictyostelium discoideum)
STE4 [plasma membrane] (Saccharomyces cerevisiae)
Gbeta13F [plasma membrane] (Drosophila melanogaster)
gpb-1 [plasma membrane] (Caenorhabditis elegans)
G-protein beta 1 subunit [plasma membrane] (Mus musculus)
Gbeta76C [plasma membrane] (Drosophila melanogaster)
gnb1b [plasma membrane] (Danio rerio)
GNB1 [plasma membrane] (Canis familiaris)
GNB1 [plasma membrane] (Gallus gallus)
GNB1 [plasma membrane] (Sus scrofa)
GNB1 [plasma membrane] (Xenopus tropicalis)
Gnb1 [plasma membrane] (Rattus norvegicus)
Homologues of GNB1 [plasma membrane] (Drosophila melanogaster)
git5 [plasma membrane] (Schizosaccharomyces pombe)
Cross References
RefSeq
XP_016856548.1
,
NP_001269468.1
,
XP_016856549.1
,
NP_002065.1
,
NP_001269467.1
,
XP_016856550.1
Target Pathogen
5b354852be737e166372e7ac
,
5b354852be737e166372e7f7
OpenTargets
ENSG00000078369
HPA
ENSG00000078369-GNB1
GeneCards
P62873
Ensembl
ENSG00000078369
,
ENSP00000367872
,
ENST00000610897
,
ENSP00000481878
,
ENST00000378609
PRO
P62873
Orphanet
25724
HMDB Protein
HMDBP08398
PDB
6P9X
,
6WHC
,
6PB1
,
6OSA
,
6LML
,
6GDG
,
6KPG
,
6PB0
,
6UUN
,
6OIJ
,
6KPF
,
6OS9
,
6EG8
,
6PT0
,
6OIK
,
6NIY
,
6LMK
,
4KFM
,
6DDF
,
6VMS
,
6M1I
,
6ORV
,
6E3Y
,
5HE3
,
6OT0
,
6UVA
,
6DDE
,
6M1H
,
4PNK
,
5UZ7
,
5UKM
,
6VCB
,
5HE2
,
6LI3
,
6CRK
,
5HE1
,
6G79
,
5UKL
,
6M8S
,
6D9H
,
6NI3
,
6UUS
,
6OMM
,
6P9Y
,
5UKK
,
6B3J
,
5HE0
,
6N4B
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
10
UniProt:P59768 GNG2
1
GNG2 [plasma membrane]
(R-HSA-164380)
0.645
4
UniProt:P60033 CD81
1
CD81 [plasma membrane]
(R-HSA-197933)
0.597
7
UniProt:P07237 P4HB
3
HC53,56-P4HB [endoplasmic reticulum lumen]
(R-HSA-3341287)
P4HB [endoplasmic reticulum lumen]
(R-HSA-174692)
p-P4HB [endoplasmic reticulum lumen]
(R-HSA-8956902)
0.556
3
UniProt:Q08AM6 VAC14
3
VAC14 [early endosome membrane]
(R-HSA-1806207)
VAC14 [late endosome membrane]
(R-HSA-1806219)
VAC14 [Golgi membrane]
(R-HSA-1806235)
0.556
3
UniProt:Q92782-2 Q927822
0.556
3
UniProt:Q9UI47-2 CTNNA3
0.556
3
UniProt:Q9NRI5 DISC1
0.553
2
UniProt:P48039 MTNR1A
1
MTNR1A [plasma membrane]
(R-HSA-419316)
0.527
2
UniProt:P0DTD1-PRO_0000449625 REP
0.527
2
UniProt:P06881 CALCA
1
CALCA(83-119) [extracellular region]
(R-HSA-419836)
0.488
2
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