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G alpha (s):GTP [plasma membrane]
Stable Identifier
R-HSA-164358
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Gs:GTP
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
ADM:CALCRL:RAMP2:G-alpha(s):GDP:G-beta:G-gamma exchanges GDP for GTP (Homo sapiens)
ADM:CALCRL:RAMP2:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
ADM:CALCRL:RAMP2:G-alpha(s):GTP:G-beta:G-gamma dissociates (Homo sapiens)
ADM:CALCRL:RAMP2:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s) activates adenylate cyclase (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs (Homo sapiens)
ADORA2B:Ade-Rib:Heterotrimeric G-protein Gs:GTP [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
ADORA2B:Ade-Rib:GsGTP dissociates (Homo sapiens)
ADORA2B:Ade-Rib:Heterotrimeric G-protein Gs:GTP [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s) activates adenylate cyclase (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Prostacyclin signalling through prostacyclin receptor (Homo sapiens)
Dissociation of the Prostacyclin receptor:Gs complex (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
Gs activation by prostacyclin receptor (Homo sapiens)
Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Glucagon signaling in metabolic regulation (Homo sapiens)
G alpha (s) activates adenylate cyclase (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G(s):GTP activates Adenylyl cyclase (Homo sapiens)
ADCY5,6,8:G-alpha(s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
Glucagon:GCGR mediates GTP-GDP exchange (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
PKA activation in glucagon signalling (Homo sapiens)
Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Homo sapiens)
Activated Adenylyl cyclase synthesizes cyclic AMP (Homo sapiens)
ADCY5,6,8:G-alpha(s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G(s):GTP activates Adenylyl cyclase (Homo sapiens)
ADCY5,6,8:G-alpha(s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GLP1R:GLP1 activates G(s) (Homo sapiens)
GLP-1:GLP-1R:Heterotrimeric G(s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
Heterotrimeric G(s) complex dissociates (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s) activates adenylate cyclase (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP:SRC [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP:p-Y419-SRC [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP:SRC dissociates (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP:p-Y419-SRC [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G protein alpha (s):GTP binds SRC (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP:SRC [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GPER1 signaling (Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs (active):ESTG [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
ESTG-stimulated dissociation of GPER:heterotrimeric G-protein (s) complex (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs (active):ESTG [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s) activates adenylate cyclase (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (z) signalling events (Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Aquaporin-mediated transport (Homo sapiens)
Vasopressin regulates renal water homeostasis via Aquaporins (Homo sapiens)
AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Homo sapiens)
AVPR2:AVP:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s) activates adenylate cyclase (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
Heterotrimeric G(s) complex dissociates (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
Participants
components
GNAS [plasma membrane]
(Homo sapiens)
GTP [cytosol]
Participates
as an input of
G(s):GTP activates Adenylyl cyclase (Homo sapiens)
G protein alpha (s):GTP binds SRC (Homo sapiens)
G alpha (s) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
G alpha (s) activates adenylate cyclase (Homo sapiens)
as a component of
ADCY5,6,8:G-alpha(s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP:p-Y419-SRC [plasma membrane] (Homo sapiens)
G alpha (s):GTP:SRC [plasma membrane] (Homo sapiens)
GLP-1:GLP-1R:Heterotrimeric G(s):GTP [plasma membrane] (Homo sapiens)
G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
as an output of
G alpha (s):GTP:SRC dissociates (Homo sapiens)
ESTG-stimulated dissociation of GPER:heterotrimeric G-protein (s) complex (Homo sapiens)
ADM:CALCRL:RAMP2:G-alpha(s):GTP:G-beta:G-gamma dissociates (Homo sapiens)
Heterotrimeric G(s) complex dissociates (Homo sapiens)
Glucagon:GCGR mediates GTP-GDP exchange (Homo sapiens)
ADORA2B:Ade-Rib:GsGTP dissociates (Homo sapiens)
Dissociation of the Prostacyclin receptor:Gs complex (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
This entity regulates
Positively
GPR161 promotes cAMP production in a G alpha(s)-dependent manner
(Homo sapiens)
Inferred To
G alpha (s):GTP [plasma membrane]
(Bos taurus)
G alpha (s):GTP [plasma membrane]
(Caenorhabditis elegans)
G alpha (s):GTP [plasma membrane]
(Canis familiaris)
G alpha (s):GTP [plasma membrane]
(Danio rerio)
G alpha (s):GTP [plasma membrane]
(Drosophila melanogaster)
G alpha (s):GTP [plasma membrane]
(Gallus gallus)
G alpha (s):GTP [plasma membrane]
(Mus musculus)
G alpha (s):GTP [plasma membrane]
(Rattus norvegicus)
G alpha (s):GTP [plasma membrane]
(Sus scrofa)
G alpha (s):GTP [plasma membrane]
(Xenopus tropicalis)
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