PKA activation in glucagon signalling

Stable Identifier
R-HSA-164378
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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PKA activation in glucagon signalling
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Adenylate cyclase catalyses the synthesis of cyclic AMP (cAMP) from ATP. In the absence of cAMP, protein kinase A (PKA) exists as inactive tetramers of two catalytic subunits and two regulatory subunits. cAMP binding to PKA tetramers causes them to dissociate and release their catalytic subunits as active monomers. Four isoforms of the regulatory subunit are known, that differ in their tissue specificity and functional characteristics, but the specific isoform activated in response to glucagon signaling has not yet been identified.
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Event Information
Go Biological Process
cellular response to glucagon stimulus (0071377)
Orthologous Events
PKA activation in glucagon signalling (Bos taurus)
PKA activation in glucagon signalling (Caenorhabditis elegans)
PKA activation in glucagon signalling (Canis familiaris)
PKA activation in glucagon signalling (Danio rerio)
PKA activation in glucagon signalling (Drosophila melanogaster)
PKA activation in glucagon signalling (Gallus gallus)
PKA activation in glucagon signalling (Mus musculus)
PKA activation in glucagon signalling (Rattus norvegicus)
PKA activation in glucagon signalling (Saccharomyces cerevisiae)
PKA activation in glucagon signalling (Schizosaccharomyces pombe)
PKA activation in glucagon signalling (Sus scrofa)
PKA activation in glucagon signalling (Xenopus tropicalis)
Authored
Gopinathrao, G  (2005-05-19)
D'Eustachio, P  (2005-05-19)
Created
Gopinathrao, G  (2005-05-19)
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