Minus strand DNA synthesis resumes

Stable Identifier
R-HSA-164520
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol
ReviewStatus
5/5
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Minus strand DNA synthesis resumes
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Synthesis of minus-strand DNA proceeds toward the 5' end of the PBS motif of the template HIV genomic RNA.
Literature References
PubMed ID Title Journal Year
10723025 The HIV-1 reverse transcription (RT) process as target for RT inhibitors

De Clercq, E, Anne, J, Jonckheere, H

Med Res Rev 2000
  Retroviruses

Varmus, HE, Hughes, SH, Coffin, JM

  1997
Participants
Input
Output
Participates
as an event of
Catalyst Activity

RNA-directed DNA polymerase activity of RTC with minus sssDNA transferred to 3'-end of viral RNA template [cytosol]

Physical Entity
RTC with minus sssDNA transferred to 3'-end of viral RNA template [cytosol] (Homo sapiens)
Activity
RNA-directed DNA polymerase activity (GO:0003964)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
D'Eustachio, P  (2006-05-19)
Gopinathrao, G  (2006-05-19)
Reviewed
Hughes, SH  (2006-10-31)
Created
D'Eustachio, P  (2005-05-24)
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