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ATP5F1B [mitochondrial matrix]
Stable Identifier
R-HSA-164576
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
ATP5B, ATP synthase beta chain
Locations in the PathwayBrowser for interactor UniProt:P25090 FPR2
Expand all
Organelle biogenesis and maintenance (Homo sapiens)
Mitochondrial biogenesis (Homo sapiens)
Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
Expression of ATP5B (Homo sapiens)
ATP5F1B [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:P06576 ATP5F1B
Gene Names
ATP5F1B, ATP5B, ATPMB, ATPSB
Chain
transit peptide:1-47, chain:48-529
Reference Genes
BioGPS Gene:506 ATP5F1B
COSMIC (genes):ATP5F1B ATP5F1B
CTD Gene:506 ATP5F1B
dbSNP Gene:506 ATP5F1B
ENSEMBL:ENSG00000110955 ATP5B
HGNC:830 ATP5F1B
KEGG:hsa:506 ATP5F1B
Monarch:506 ATP5F1B
NCBI Gene:506 ATP5F1B
OMIM:102910 ATP5F1B
UCSC:P06576 ATP5F1B
Reference Transcript
RefSeq:NM_001686.3 ATP5F1B
Other Identifiers
11724190_s_at
11757873_x_at
16766260
16766279
201322_PM_at
201322_at
3458032
3458034
3458035
3458036
3458037
3458038
3458039
3458040
3458041
3458042
3458043
3458044
3458045
3458046
3458047
3458048
3458050
3458051
3458054
3458055
3458056
506
7964234
7964246
A_21_P0000374
A_23_P33216
GE57035
GO:0001525
GO:0001649
GO:0003824
GO:0005215
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005739
GO:0005743
GO:0005759
GO:0005886
GO:0006091
GO:0006629
GO:0006754
GO:0006811
GO:0006933
GO:0009986
GO:0015986
GO:0016020
GO:0016469
GO:0016787
GO:0016874
GO:0016887
GO:0030154
GO:0031966
GO:0042288
GO:0042645
GO:0042776
GO:0043226
GO:0043532
GO:0043536
GO:0045259
GO:0045261
GO:0046034
GO:0046933
GO:0046961
GO:0051453
GO:0055085
GO:0055086
GO:0070062
GO:0098761
GO:0140657
GO:1901135
GO:1902495
GO:1902600
HMNXSV003021703
HMNXSV003039648
ILMN_1772132
M19483_at
PH_hs_0019285
RNA33693|snoRNA_scaRNA_289_75
TC12001609.hg
TC12001610.hg
g4502294_3p_at
Participates
as an output of
Expression of ATP5B (Homo sapiens)
as a member of
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
as a component of
ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
Other forms of this molecule
ATP5B(1-529) [cytosol]
ATP5B(1-529) [mitochondrial intermembrane space]
ATP5B(1-529) [mitochondrial inner membrane]
ATP5B(1-47) [mitochondrial matrix]
ATP5B [mitochondrial inner membrane]
Inferred To
atp-2 [mitochondrial matrix]
(Caenorhabditis elegans)
ATP2 [mitochondrial matrix]
(Saccharomyces cerevisiae)
atp5f1b [mitochondrial matrix]
(Danio rerio)
atp5f1b [mitochondrial matrix]
(Dictyostelium discoideum)
atp5f1b [mitochondrial matrix]
(Xenopus tropicalis)
ATP5F1B [mitochondrial matrix]
(Bos taurus)
ATP5F1B [mitochondrial matrix]
(Canis familiaris)
ATP5F1B [mitochondrial matrix]
(Gallus gallus)
ATP5F1B [mitochondrial matrix]
(Sus scrofa)
ATPsynbeta [mitochondrial matrix]
(Drosophila melanogaster)
atp2 [mitochondrial matrix]
(Schizosaccharomyces pombe)
Atp5f1b [mitochondrial matrix]
(Mus musculus)
Atp5f1b [mitochondrial matrix]
(Rattus norvegicus)
Cross References
RefSeq
NP_001677.2
Guide to Pharmacology - Targets
797
OpenTargets
ENSG00000110955
ENSEMBL
ENSG00000110955
,
ENSP00000262030
,
ENST00000262030
GeneCards
ATP5F1B
HPA
ENSG00000110955-ATP5F1B
PRO
P06576
Pharos - Targets
P06576
GlyGen
P06576
HMDB Protein
HMDBP01465
PDB
8H9E
,
8H9U
,
8H9L
,
8H9I
,
8H9S
,
8H9V
,
8H9T
,
8KI3
,
8H9P
Interactors (53)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8N5M1 ATPF2
0.848
9
UniProt:P25705 ATP5F1A
3
ATP5F1A [mitochondrial matrix]
(R-HSA-164575)
ATP5A1(1-553) [cytosol]
(R-HSA-1267955)
ATP5A1(1-553) [mitochondrial intermembrane space]
(R-HSA-1267978)
0.802
8
UniProt:Q9UII2 ATIF1
0.744
5
UniProt:P24539 ATP5PB
1
ATP5PB [mitochondrial inner membrane]
(R-HSA-164537)
0.744
6
UniProt:Q5TC12 ATPF1
0.738
4
UniProt:O60779 SLC19A2
1
SLC19A2 [plasma membrane]
(R-HSA-199636)
0.725
4
UniProt:Q5T1Q4 S35F1
0.688
3
UniProt:O75947 ATP5PD
1
ATP5PD [mitochondrial inner membrane]
(R-HSA-50522)
0.669
3
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.643
4
UniProt:O75964 ATP5MG
1
ATP5MG [mitochondrial inner membrane]
(R-HSA-50518)
0.643
3
UniProt:Q86VR2 RETR3
0.643
3
UniProt:P25106 ACKR3
1
CXCR7 [plasma membrane]
(R-HSA-373859)
0.643
3
UniProt:P48047 ATP5PO
1
ATP5PO [mitochondrial inner membrane]
(R-HSA-164533)
0.643
3
UniProt:P18859 ATP5PF
1
ATP5PF [mitochondrial inner membrane]
(R-HSA-164532)
0.643
4
UniProt:Q96G23 CERS2
1
CERS2 [endoplasmic reticulum membrane]
(R-HSA-428171)
0.643
3
UniProt:P36542 ATP5F1C
1
ATP5F1C [mitochondrial matrix]
(R-HSA-164577)
0.623
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
20
UniProt:P28566 HTR1E
1
HTR1E [plasma membrane]
(R-HSA-390960)
0.564
2
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.564
2
UniProt:P54253 ATX1
0.556
3
UniProt:Q13895 BYSL
2
BYSL [nucleoplasm]
(R-HSA-6791526)
BYSL [cytosol]
(R-HSA-6791518)
0.556
3
UniProt:Q8N448 LNX2
0.553
4
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.536
2
UniProt:Q99679 GPR21
0.527
2
UniProt:O60512 B4GALT3
1
B4GALT3 [Golgi membrane]
(R-HSA-975922)
0.527
4
UniProt:P03928 MT-ATP8
1
MT-ATP8 [mitochondrial inner membrane]
(R-HSA-50500)
0.527
2
UniProt:P0DTD1-PRO_0000449624 REP
0.527
2
UniProt:P30049 ATP5F1D
1
ATP5F1D [mitochondrial matrix]
(R-HSA-164574)
0.527
2
UniProt:Q06136 KDSR
1
KDSR [endoplasmic reticulum membrane]
(R-HSA-428134)
0.527
2
UniProt:O95136 S1PR2
1
S1PR2 [plasma membrane]
(R-HSA-419419)
0.527
2
UniProt:P48201 ATP5MC3
1
ATP5MC3 [mitochondrial inner membrane]
(R-HSA-5216110)
0.527
2
UniProt:Q9HC97 GPR35
1
GPR35 [plasma membrane]
(R-HSA-3295332)
0.527
2
UniProt:P27449 ATP6V0C
7
ATP6V0C [endosome membrane]
(R-HSA-912591)
ATP6V0C [azurophil granule membrane]
(R-HSA-6799363)
ATP6V0C [plasma membrane]
(R-HSA-6806254)
ATP6V0C [tertiary granule membrane]
(R-HSA-6800991)
ATP6V0C [ficolin-1-rich granule membrane]
(R-HSA-6800908)
ATP6V0C [phagocytic vesicle membrane]
(R-HSA-1222603)
ATP6V0C [lysosomal membrane]
(R-HSA-9640194)
0.527
3
UniProt:Q9H244 P2RY12
1
P2RY12 [plasma membrane]
(R-HSA-391959)
0.527
2
UniProt:Q6ZMG9 CERS6
1
CERS6 [endoplasmic reticulum membrane]
(R-HSA-428145)
0.527
2
UniProt:Q5I7T1 ALG10B
1
ALG10B [endoplasmic reticulum membrane]
(R-HSA-449653)
0.527
2
UniProt:Q5K4L6 SLC27A3
1
SLC27A3 [mitochondrial matrix]
(R-HSA-5216184)
0.527
2
UniProt:P25090 FPR2
4
FPR2 [plasma membrane]
(R-HSA-416408)
FPR2 [specific granule membrane]
(R-HSA-6803319)
FPR2 [tertiary granule membrane]
(R-HSA-6803296)
FPR2 [ficolin-1-rich granule membrane]
(R-HSA-6803335)
0.527
2
UniProt:P32241 VIPR1
1
VIPR1 [plasma membrane]
(R-HSA-420157)
0.527
2
UniProt:Q9NX36 DJC28
0.527
2
UniProt:Q9BXJ8 TACAN
0.527
2
UniProt:O15127 SCAM2
0.527
2
UniProt:Q7Z7J7 LHPL4
0.527
2
UniProt:Q9H1C4 UNC93B1
4
UNC93B1 [Golgi membrane]
(R-HSA-1679064)
UNC93B1 [endoplasmic reticulum membrane]
(R-HSA-1678930)
UNC93B1 P345Pfs*103 [endoplasmic reticulum membrane]
(R-HSA-9628866)
UNC93B1 L230Afs*188 [endoplasmic reticulum membrane]
(R-HSA-9628869)
0.527
2
UniProt:P41587 VIPR2
1
VIPR2 [plasma membrane]
(R-HSA-420227)
0.527
3
UniProt:Q8IXU6 S35F2
0.527
2
UniProt:P56385 ATP5ME
1
ATP5ME [mitochondrial inner membrane]
(R-HSA-50514)
0.527
2
UniProt:P51451 BLK
2
MyrG2-BLK [plasma membrane]
(R-HSA-9606871)
BLK [cytosol]
(R-HSA-983580)
0.527
2
UniProt:P28335 HTR2C
1
HTR2C [plasma membrane]
(R-HSA-390965)
0.527
2
UniProt:Q8IUW5 RELL1
0.527
2
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.483
2
UniProt:A0A0F6B1Q8 A0A0F6B1Q8
0.462
2
UniProt:P05919 vpu
6
VPU (P05919) protein [cytosol]
(R-HIV-173223)
VPU (P05919) [endoplasmic reticulum membrane]
(R-HIV-180550)
VPU (P05919) protein [extracellular region]
(R-HIV-175522)
VPU (P05919) protein [nucleoplasm]
(R-HIV-175200)
VPU (P05919) [Golgi membrane]
(R-HIV-3149439)
VPU (P05919) [plasma membrane]
(R-HIV-3149423)
0.462
2
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