Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PLK1 [cytosol]
Stable Identifier
R-HSA-164603
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Recruitment of NuMA to mitotic centrosomes (Homo sapiens)
Association of NuMA with microtubules (Homo sapiens)
Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
p-T2055-NUMA1 homodimer:Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Translocation of NuMA to the centrosomes (Homo sapiens)
Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
PLK1 phosphorylates FIRMM at S744 (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
PPP1CC dephosphorylates PLK1 (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
AURKA Activation by TPX2 (Homo sapiens)
TPX2 binds AURKA at centrosomes (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Centrosome:AURKA:TPX2:HMMR [cytosol] (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
TPX2 promotes AURKA autophosphorylation (Homo sapiens)
Centrosome:AURKA:TPX2:HMMR [cytosol] (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA:TPX2:HMMR [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Centrosome maturation (Homo sapiens)
Loss of proteins required for interphase microtubule organization from the centrosome (Homo sapiens)
Loss of C-Nap-1 from centrosomes (Homo sapiens)
cNAP-1 depleted centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Loss of Nlp from mitotic centrosomes (Homo sapiens)
Dissociation of Phospho-Nlp from the centrosome (Homo sapiens)
Nlp-depleted centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
centrosome containing phosphorylated Nlp [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Plk1-mediated phosphorylation of Nlp (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
centrosome containing phosphorylated Nlp [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Recruitment of mitotic centrosome proteins and complexes (Homo sapiens)
Recruitment of CDK11p58 to the centrosomes (Homo sapiens)
Centrosomes containing recruited CDK11p58 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Recruitment of Plk1 to centrosomes (Homo sapiens)
Centrosome associated Plk1 [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Homo sapiens)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Cyclin A/B1/B2 associated events during G2/M transition (Homo sapiens)
Phosphorylation of Cyclin B1 in the CRS domain (Homo sapiens)
CRS kinase [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Polo-like kinase mediated events (Homo sapiens)
FOXM1 stimulates PLK1 transcription (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Regulation of PLK1 Activity at G2/M Transition (Homo sapiens)
AJUBA binds centrosome-associated AURKA (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Centrosome:AURKA:AJUBA [cytosol] (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
AJUBA facilitates AURKA autophosphorylation (Homo sapiens)
Centrosome:AURKA:AJUBA [cytosol] (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
AURKA phosphorylates PLK1 (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
p-S252-BORA:PLK1 [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
BORA binds PLK1 and AURKA (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
p-S252-BORA:PLK1 [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
Association of cell cycle proteins with the APC/C:Cdh1 complex (Homo sapiens)
(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Degradation of multiubiquitinated cell cycle proteins (Homo sapiens)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Homo sapiens)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Homo sapiens)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Homo sapiens)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation (Homo sapiens)
MITF-M-dependent PLK1 expression (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
Anchoring of the basal body to the plasma membrane (Homo sapiens)
C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
C2CD3 binds the mother centriole (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
basal body:transition zone proteins [cytosol] (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
basal body:transition zone proteins [cytosol] (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
CP110 and CEP97 dissociate from the centriole (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
MARK4 binds ODF2 in the centriole (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
basal body:transition zone proteins [cytosol] (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Recruitment of transition zone proteins (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
basal body:transition zone proteins [cytosol] (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
The distal appendage proteins recruit TTBK2 (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PLK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P53350 PLK1
Gene Names
PLK1, PLK
Chain
initiator methionine:, chain:2-603
Reference Genes
BioGPS Gene:5347 PLK1
COSMIC (genes):PLK1 PLK1
CTD Gene:5347 PLK1
dbSNP Gene:5347 PLK1
ENSEMBL:ENSG00000166851 PLK1
ENSEMBL_homo_sapiens_GENE:ENSG00000166851.15 PLK1
HGNC:9077 PLK1
KEGG Gene (Homo sapiens):5347 PLK1
Monarch:5347 PLK1
NCBI Gene:5347 PLK1
OMIM:602098 PLK1
UCSC:P53350 PLK1
Reference Transcript
RefSeq:NM_005030.5 PLK1
Other Identifiers
11716726_a_at
11716727_x_at
11750302_a_at
16817017
202240_PM_at
202240_at
3137730
3653073
3653074
3653075
3653076
3653079
3653080
3653081
3653083
3653085
3653086
3653088
3653090
3653092
3653093
37228_at
5347
7994109
A_14_P113539
A_24_P313504
A_33_P3298387
GO:0000070
GO:0000086
GO:0000122
GO:0000132
GO:0000166
GO:0000228
GO:0000278
GO:0000281
GO:0000287
GO:0000775
GO:0000776
GO:0000779
GO:0000785
GO:0000795
GO:0000910
GO:0000922
GO:0000940
GO:0001578
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005813
GO:0005814
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005876
GO:0006281
GO:0006302
GO:0006351
GO:0006355
GO:0006468
GO:0007010
GO:0007049
GO:0007052
GO:0007059
GO:0007062
GO:0007076
GO:0007077
GO:0007091
GO:0007094
GO:0007095
GO:0007098
GO:0007163
GO:0007346
GO:0008017
GO:0008092
GO:0010800
GO:0010997
GO:0012501
GO:0015630
GO:0016301
GO:0016310
GO:0016321
GO:0016567
GO:0016740
GO:0018105
GO:0019901
GO:0022414
GO:0023052
GO:0030071
GO:0030163
GO:0030496
GO:0031648
GO:0032436
GO:0032465
GO:0033365
GO:0034451
GO:0036211
GO:0042802
GO:0043066
GO:0043226
GO:0043393
GO:0045143
GO:0045184
GO:0045736
GO:0045862
GO:0048313
GO:0051081
GO:0051233
GO:0051301
GO:0051443
GO:0051726
GO:0061024
GO:0070194
GO:0071168
GO:0090435
GO:0097431
GO:0097681
GO:0106310
GO:0140013
GO:0140014
GO:0140096
GO:1900182
GO:1901673
GO:1901990
GO:1904668
GO:1904776
GO:1905784
HMNXSV003006606
ILMN_1736176
PH_hs_0032688
TC16000258.hg
U01038_at
g4826915_3p_at
Participates
as a component of
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
p-S217,277,376-Gorasp1:PLK1 [Golgi membrane] (Homo sapiens)
Centrosome associated Plk1 [cytosol] (Homo sapiens)
Nlp-depleted centrosome [cytosol] (Homo sapiens)
centrosome containing phosphorylated Nlp [cytosol] (Homo sapiens)
cNAP-1 depleted centrosome [cytosol] (Homo sapiens)
p-S252-BORA:PLK1 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
as an output of
MITF-M-dependent PLK1 expression (Homo sapiens)
PPP1CC dephosphorylates PLK1 (Homo sapiens)
FOXM1 stimulates PLK1 transcription (Homo sapiens)
as an input of
PLK1 binds phosphorylated Gorasp1 (Homo sapiens)
Recruitment of Plk1 to centrosomes (Homo sapiens)
BORA binds PLK1 and AURKA (Homo sapiens)
as a member of
(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Homo sapiens)
as a candidate of
CRS kinase [cytosol] (Homo sapiens)
Other forms of this molecule
PLK1 [nucleoplasm]
p-T210-PLK1 [cytosol]
p-T210-PLK1 [nucleoplasm]
Inferred To
PLK1 [cytosol]
(Bos taurus)
PLK1 [cytosol]
(Caenorhabditis elegans)
PLK1 [cytosol]
(Canis familiaris)
PLK1 [cytosol]
(Danio rerio)
PLK1 [cytosol]
(Dictyostelium discoideum)
PLK1 [cytosol]
(Drosophila melanogaster)
PLK1 [cytosol]
(Gallus gallus)
PLK1 [cytosol]
(Mus musculus)
PLK1 [cytosol]
(Plasmodium falciparum)
PLK1 [cytosol]
(Rattus norvegicus)
PLK1 [cytosol]
(Saccharomyces cerevisiae)
PLK1 [cytosol]
(Schizosaccharomyces pombe)
PLK1 [cytosol]
(Sus scrofa)
PLK1 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_005021.2
ZINC - World Drugs
PLK1_HUMAN
Guide to Pharmacology - Targets
2168
OpenTargets
ENSG00000166851
ZINC - FDA approved
PLK1_HUMAN
ZINC - Substances
PLK1_HUMAN
ZINC - Biogenic
PLK1_HUMAN
ZINC target
P53350
PRO
P53350
PDB
8XB9
,
2OGQ
,
4E67
,
4X9W
,
2OWB
,
2V5Q
,
4H71
,
8BJT
,
4O6W
,
4WHL
,
3P36
,
4X9R
,
4WHK
,
5NFU
,
4E9D
,
4E9C
,
4X9V
,
5NJE
,
7MX1
,
8X72
,
1UMW
,
3THB
,
5TA8
,
8CRC
,
8JOQ
,
5NN1
,
4O9W
,
5TA6
,
5NN2
,
4J52
,
4A4O
,
6GY2
,
3Q1I
,
4H5X
,
4J53
,
4HAB
,
3HIH
,
1Q4K
,
5NMM
,
3HIK
,
4RCP
,
4A4L
,
3C5L
,
1Q4O
,
5NEI
,
6AX4
,
3P37
,
5J19
,
3BZI
,
3RQ7
,
7MSO
,
2YAC
,
2OU7
,
4LKL
,
8JOY
,
3P2W
,
4O56
,
3P35
,
3KB7
,
3P34
,
2OJX
,
4HY2
,
4LKM
,
3P2Z
,
3FC2
,
4WHH
,
4HCO
,
4DFW
,
3FVH
,
2RKU
ZINC - Investigational
PLK1_HUMAN
ZINC - Metabolites
PLK1_HUMAN
GeneCards
P53350
HPA
ENSG00000166851-PLK1
Ensembl
ENST00000300093
,
ENSP00000300093
,
ENSG00000166851
Pharos - Targets
P53350
ZINC - Predictions - Purchasable
PLK1_HUMAN
HMDB Protein
HMDBP01514
Interactors (94)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P30307 CDC25C
8
p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol]
(R-HSA-8863654)
p-S191-CDC25C [nucleoplasm]
(R-HSA-6802968)
p-S216-CDC25C [cytosol]
(R-HSA-75003)
p-S216-CDC25C [nucleoplasm]
(R-HSA-156496)
CDC25C [nucleoplasm]
(R-HSA-69741)
CDC25C [cytosol]
(R-HSA-157879)
p-S198-CDC25C [cytosol]
(R-HSA-8981697)
p-S198-CDC25C [nucleoplasm]
(R-HSA-156668)
0.858
8
UniProt:Q6PGQ7 BORA
3
p-S252-BORA [cytosol]
(R-HSA-4086411)
p-S252,S497,T501-BORA [cytosol]
(R-HSA-3000330)
BORA [cytosol]
(R-HSA-2562607)
0.848
9
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.797
4
UniProt:O60271 SPAG9
1
SPAG9 [cytosol]
(R-HSA-375975)
0.789
7
UniProt:Q2NKX8 ERCC6L
1
ERCC6L [cytosol]
(R-HSA-376250)
0.788
6
UniProt:Q8IY92 SLX4
1
SLX4 [nucleoplasm]
(R-HSA-5686477)
0.777
8
UniProt:Q92889 ERCC4
1
ERCC4 [nucleoplasm]
(R-HSA-67445)
0.773
6
UniProt:O75170 PP6R2
0.745
7
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.737
6
UniProt:Q9NYF3 FA53C
0.725
5
UniProt:O96017 CHEK2
3
p-T68-CHEK2 [nucleoplasm]
(R-HSA-113825)
CHEK2 [nucleoplasm]
(R-HSA-113824)
p-S,3T-CHEK2 [nucleoplasm]
(R-HSA-5683784)
0.72
7
UniProt:Q12888 TP53BP1
3
monoSUMO1-K-TP53BP1 [nucleoplasm]
(R-HSA-2997591)
p-S25,S1778-TP53BP1 [nucleoplasm]
(R-HSA-5683418)
TP53BP1 [nucleoplasm]
(R-HSA-61175)
0.718
6
UniProt:Q9H0H5 RACGAP1
1
RACGAP1 [cytosol]
(R-HSA-195122)
0.71
4
UniProt:Q13158 FADD
1
FADD [cytosol]
(R-HSA-54639)
0.676
9
UniProt:Q92844 TANK
2
TANK [cytosol]
(R-HSA-933407)
K63polyUb-TANK [cytosol]
(R-HSA-5362480)
0.674
4
UniProt:O95251 KAT7
1
KAT7 [nucleoplasm]
(R-HSA-3321823)
0.671
6
UniProt:P49736 MCM2
1
MCM2 [nucleoplasm]
(R-HSA-68557)
0.657
3
UniProt:O60447 EVI5
0.656
3
UniProt:Q71F23-1 CENPU
0.65
5
UniProt:O75052 CAPON
0.643
3
UniProt:Q86VG3 IFTAP
0.643
3
UniProt:P82094 TMF1
1
TMF1 [cytosol]
(R-HSA-8847539)
0.643
3
UniProt:Q8TD16 BICD2
1
BICD2 [cytosol]
(R-HSA-8848107)
0.643
5
UniProt:Q86WB0 ZC3HC1
2
p-S354 ZC3HC1 [nucleoplasm]
(R-HSA-9724996)
ZC3HC1 [nucleoplasm]
(R-HSA-9724992)
0.643
5
UniProt:O15084 ANKRD28
2
ANKRD28 [cytosol]
(R-HSA-5685714)
ANKRD28 [nucleoplasm]
(R-HSA-9686571)
0.643
3
UniProt:Q9UPW6 SATB2
2
polySUMO3-K233,K350-SATB2 [nucleoplasm]
(R-HSA-4615865)
SATB2 [nucleoplasm]
(R-HSA-4615944)
0.643
3
UniProt:Q9UKN8 GTF3C4
1
GTF3C4 [nucleoplasm]
(R-HSA-83689)
0.638
3
UniProt:P61962 DCAF7
2
DCAF7 [nucleoplasm]
(R-HSA-8863312)
Unfolded DCAF7 [cytosol]
(R-HSA-6813821)
0.638
3
UniProt:Q9Y5Q8 GTF3C5
1
GTF3C5 [nucleoplasm]
(R-HSA-83693)
0.638
3
UniProt:Q99741 CDC6
4
CDC6 [nucleoplasm]
(R-HSA-68542)
p-CDC6 [nucleoplasm]
(R-HSA-5661317)
p-CDC6 [cytosol]
(R-HSA-68583)
CDC6 [cytosol]
(R-HSA-113566)
0.632
6
UniProt:Q60838
5
Dvl2 [cytosol]
(R-MMU-4652689)
Dvl2 [cytosol]
(R-MMU-201694)
phospho-Dvl2 [clathrin-coated endocytic vesicle]
(R-MMU-5138444)
phospho-Dvl2 [cytosol]
(R-MMU-201706)
phospho-Dvl2 [cytosol]
(R-MMU-3772398)
0.632
12
UniProt:Q8TD19 NEK9
3
p-S29,T210,T333,S750,S869-NEK9 [cytosol]
(R-HSA-2984225)
p-T333-NEK9 [cytosol]
(R-HSA-2530600)
p-S29,T333,S750,S869-NEK9 [cytosol]
(R-HSA-2984213)
0.625
5
UniProt:O75665 OFD1
1
OFD1 [cytosol]
(R-HSA-380318)
0.618
4
UniProt:Q9NR09 BIRC6
2
BIRC6(1-958)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713451)
BIRC6(1-958)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713450)
0.602
4
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.602
7
UniProt:P54132 BLM
2
4SUMO2,3-BLM [nucleoplasm]
(R-HSA-4568883)
BLM [nucleoplasm]
(R-HSA-174881)
0.591
4
UniProt:P30291 WEE1
3
p-WEE1 [nucleoplasm]
(R-HSA-156491)
p-S53-WEE1 [nucleoplasm]
(R-HSA-156694)
WEE1 [nucleoplasm]
(R-HSA-69253)
0.59
2
UniProt:P08107 HSP71
0.571
5
UniProt:Q9NYZ3 GTSE1
4
GTSE1 [cytosol]
(R-HSA-8852264)
p-S435-GTSE1 [cytosol]
(R-HSA-8852316)
p-S435-GTSE1 [nucleoplasm]
(R-HSA-8852332)
p-T513,T526-GTSE1 [cytosol]
(R-HSA-8852308)
0.571
6
UniProt:A1L170 CA226
0.564
2
UniProt:O14641 DVL2
5
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
DVL2 [cytosol]
(R-HSA-201694)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.564
2
UniProt:Q5HYW2 NHSL2
0.556
3
UniProt:P49768-2 PSEN1
0.556
3
UniProt:Q15583 TGIF1
1
TGIF1 [nucleoplasm]
(R-HSA-2186594)
0.556
3
UniProt:Q14790 CASP8
8
CASP8(1-374) [cytosol]
(R-HSA-3465404)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(217-374) [cytosol]
(R-HSA-75975)
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(1-479) [cytosol]
(R-HSA-57031)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q16659 MAPK6 gene
6
ub-MAPK6 [cytosol]
(R-HSA-5687000)
MAPK6 [cytosol]
(R-HSA-5686979)
p-S189 MAPK6 [cytosol]
(R-HSA-5687019)
p-S189 MAPK6 [nucleoplasm]
(R-HSA-5687015)
MAPK6 [nucleoplasm]
(R-HSA-5692686)
p-3S,T MAPK6 [nucleoplasm]
(R-HSA-5692665)
0.547
2
UniProt:Q76N32 CEP68
0.544
2
UniProt:O60359 CACNG3
2
CACNG3 [plasma membrane]
(R-HSA-210465)
CACNG3 [endocytic vesicle membrane]
(R-HSA-416853)
0.527
2
UniProt:Q5VYV7 SLX4I
0.527
2
UniProt:Q8NB46 ANR52
0.527
2
UniProt:Q71F23 CENPU
2
MLF1IP [nucleoplasm]
(R-HSA-606309)
MLF1IP [cytosol]
(R-HSA-375315)
0.527
2
UniProt:Q6ZWJ1 STXB4
0.527
2
UniProt:Q8TEB1 DCAF11
1
DCAF11 [nucleoplasm]
(R-HSA-8863251)
0.527
2
UniProt:Q9NYP9 MIS18A
1
MIS18A [nucleoplasm]
(R-HSA-606299)
0.527
2
UniProt:Q99689 FEZ1
0.527
2
UniProt:Q9P286 PAK5
2
PAK7 [plasma membrane]
(R-HSA-211555)
PAK5 [cytosol]
(R-HSA-428459)
0.527
2
UniProt:Q9BZF3 OSBPL6
1
OSBPL6 [cytosol]
(R-HSA-8867534)
0.527
2
UniProt:Q9BQ83 SLX1A
1
SLX1A [nucleoplasm]
(R-HSA-5686481)
0.527
2
UniProt:Q9H6R7 WDCP
2
WDCP(1-680)-p-7Y-ALK(1061-1620) fusion [cytosol]
(R-HSA-9700468)
WDCP(1-680)-ALK(1061-1620) fusion [cytosol]
(R-HSA-9700460)
0.527
2
UniProt:P10644 PRKAR1A
4
PRKAR1A(1-183)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713476)
PRKAR1A(1-183)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713471)
PRKAR1A [ciliary base]
(R-HSA-5610408)
PRKAR1A [cytosol]
(R-HSA-57836)
0.527
2
UniProt:Q9Y5Q9 GTF3C3
1
GTF3C3 [nucleoplasm]
(R-HSA-83691)
0.527
2
UniProt:O60296 TRAK2
1
TRAK2 [cytosol]
(R-HSA-9693815)
0.527
3
UniProt:Q86XD5 FAM131B
2
FAM131B(1-18)-BRAF(381-766) fusion [cytosol]
(R-HSA-6802323)
FAM131B(1-18)-p-BRAF(381-766) fusion [cytosol]
(R-HSA-6802527)
0.527
2
UniProt:Q6WCQ1 MPRIP
2
MPRIP(2-1015)-RAF1(279-648) fusion [cytosol]
(R-HSA-6802406)
MPRIP(2-1015)-p-RAF1(279-648) fusion [cytosol]
(R-HSA-6802540)
0.527
2
UniProt:O00743 PPP6C
2
PPP6C [cytosol]
(R-HSA-5685719)
PPP6C [nucleoplasm]
(R-HSA-9686576)
0.527
2
UniProt:Q9P0K7 RAI14
0.527
3
UniProt:Q8IW35 CEP97
1
CEP97 [cytosol]
(R-HSA-5626440)
0.527
2
UniProt:Q13188 STK3
4
p-T180-STK3(1-322) [cytosol]
(R-HSA-2028696)
STK3(323-491) [cytosol]
(R-HSA-2028684)
STK3(1-491) [cytosol]
(R-HSA-2028280)
p-T180-STK3(1-491) [cytosol]
(R-HSA-2028274)
0.527
2
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.527
2
UniProt:Q9UHD2 TBK1
5
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
p-TBK1 [cytosol]
(R-HSA-9008705)
K63polyUb-K30,K401-TBK1 [cytosol]
(R-HSA-9730430)
TBK1 [cytosol]
(R-HSA-166267)
p-S172-TBK1 [cytosol]
(R-HSA-168379)
0.527
2
UniProt:Q13627 DYRK1A
1
DYRK1A [nucleoplasm]
(R-HSA-1362267)
0.527
2
UniProt:Q92547 TOPBP1
1
TOPBP1 [nucleoplasm]
(R-HSA-5684878)
0.527
3
UniProt:O14965 AURKA
6
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
AURKA [nucleoplasm]
(R-HSA-4655443)
AURKA [cytosol]
(R-HSA-174254)
p-T288-AURKA [cytosol]
(R-HSA-2574832)
0.525
4
UniProt:P33993 MCM7
1
MCM7 [nucleoplasm]
(R-HSA-68555)
0.524
4
UniProt:Q9Y4E8 USP25
1
USP15 [cytosol]
(R-HSA-2173138)
0.508
2
UniProt:Q9Y6A4 CFA20
0.508
2
UniProt:Q96R06 SPAG5
0.508
2
UniProt:Q14683 SMC1A
4
SMC1A [cytosol]
(R-HSA-2484798)
SMC1A [chromosome]
(R-HSA-1638774)
SMC1A [chromosome, centromeric region]
(R-HSA-2466015)
SMC1A [nucleoplasm]
(R-HSA-64561)
0.508
2
UniProt:Q92949 FOXJ1
0.508
2
UniProt:Q15393 SF3B3
1
SF3B3 [nucleoplasm]
(R-HSA-71973)
0.508
2
UniProt:Q9Y6Y0 NS1BP
0.508
2
UniProt:Q8IXK0 PHC2
1
PHC2 [nucleoplasm]
(R-HSA-389112)
0.508
2
UniProt:P33991 MCM4
1
MCM4 [nucleoplasm]
(R-HSA-68549)
0.508
2
UniProt:Q14566 MCM6
1
MCM6 [nucleoplasm]
(R-HSA-68553)
0.508
2
UniProt:Q00613 HSF1
11
p-S121-HSF1 [cytosol]
(R-HSA-4793906)
p-S303-HSF1 [cytosol]
(R-HSA-4793927)
p-S307-HSF1 [cytosol]
(R-HSA-4793929)
p-S303,307-HSF1 [cytosol]
(R-HSA-4793922)
HSF1 [nucleoplasm]
(R-HSA-5082385)
hC36,103-HSF1 [cytosol]
(R-HSA-4793916)
p-S230-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082361)
Ac-K80-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5097238)
hC36,103-HSF1 [nucleoplasm]
(R-HSA-3371416)
p-S326-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082355)
HSF1 [cytosol]
(R-HSA-3371452)
0.508
2
UniProt:Q9UBC2 EPS15L1
2
EPS15L1 [plasma membrane]
(R-HSA-182937)
EPS15L1 [cytosol]
(R-HSA-8935900)
0.508
2
UniProt:Q92769 HDAC2
2
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
HDAC2 [nucleoplasm]
(R-HSA-205135)
0.508
2
UniProt:Q15648 MED1
1
MED1 [nucleoplasm]
(R-HSA-212445)
0.508
2
UniProt:P70399-1 TP53BP1
0.499
2
UniProt:P54727 RAD23B
2
RAD23B [nucleoplasm]
(R-HSA-62590)
RAD23B [cytosol]
(R-HSA-8850589)
0.489
2
UniProt:P23588 EIF4B
2
p-S422-EIF4B [cytosol]
(R-HSA-165773)
EIF4B [cytosol]
(R-HSA-72589)
0.489
3
UniProt:Q5BJF6 ODF2
1
ODF2 [cytosol]
(R-HSA-380293)
0.483
2
UniProt:Q99IB8-PRO_0000045602
0.463
4
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text