Nef mediated downregulation of MHC class I complex cell surface expression

Stable Identifier
R-HSA-164940
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Locations in the PathwayBrowser
Summation

Down-regulation of MHC class I involves Nef-mediated connection in the endosomes between MHC-I's cytoplasmic tail and the phosphofurin acidic cluster sorting protein-1 (PACS-1)-dependent protein-sorting pathway. Down-regulation of MHC I protects HIV-infected cells from host CTL response.

Literature References
PubMed ID Title Journal Year
12414957 Direct binding of human immunodeficiency virus type 1 Nef to the major histocompatibility complex class I (MHC-I) cytoplasmic tail disrupts MHC-I trafficking

Williams, M, Roeth, JF, Kasper, MR, Fleis, RI, Przybycin, CG, Collins, KL

J Virol 2002
11593029 HIV-1 Nef impairs MHC class II antigen presentation and surface expression

Stumptner-Cuvelette, P, Morchoisne, S, Dugast, M, Le Gall, S, Raposo, G, Schwartz, O, Benaroch, P

Proc Natl Acad Sci U S A 2001
8612235 Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein

Schwartz, O, Marechal, V, Le Gall, S, Lemonnier, F, Heard, JM

Nat Med 1996
9586638 Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules

Le Gall, S, Erdtmann, L, Benichou, S, Berlioz-Torrent, C, Liu, L, Benarous, R, Heard, JM, Schwartz, O

Immunity 1998
12526811 HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway

Blagoveshchenskaya, AD, Thomas, L, Feliciangeli, SF, Hung, CH, Thomas, G

Cell 2002
Participants
Participant Of
Event Information
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Reviewed