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The role of Nef in HIV-1 replication and disease pathogenesis
Stable Identifier
R-HSA-164952
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
ReviewStatus
5/5
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The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)
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The HIV-1 Nef protein is a 27-kDa myristoylated protein that is abundantly produced during the early phase of viral replication cycle. It is highly conserved in all primate lentiviruses, suggesting that its function is essential for survival of these pathogens. The protein name "Nef" was derived from early reports of its negative effect on viral replication, thus 'negative factor' or Nef. Subsequently it has been demonstrated that Nef plays an important role in several steps of HIV replication. In addition, it appears to be a critical pathogenic factor, as Nef-deficient SIV and HIV are significantly less pathogenic than the wild-type viruses, whereas Nef-transgenic mice show many features characteristic to HIV disease.
The role of Nef in HIV-1 replication and disease pathogenesis is determined by at least four independent activities of this protein. Nef affects the cell surface expression of several cellular proteins, interferes with cellular signal transduction pathways, enhances virion infectivity and viral replication, and regulates cholesterol trafficking in HIV-infected cells.
Literature References
PubMed ID
Title
Journal
Year
16354571
Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions
Zhao, RY
,
Bukrinsky, M
,
Pauza, CD
,
Li, HS
,
Li, L
Cell Res
2005
Participants
Events
Nef and signal transduction
(Homo sapiens)
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
(Homo sapiens)
Participates
as an event of
Host Interactions of HIV factors (Homo sapiens)
Authored
Gillespie, ME (2007-07-25)
Reviewed
Skowronski, J (2007-08-07)
Created
Gillespie, ME (2005-07-23)
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