Rev molecules assemble onto the RRE RNA sequence through their ARM sequence

Stable Identifier
R-HSA-165027
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
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Nuclear export of the unspliced and partially spliced HIV-1 transcripts requires the association of the HIV-1 Rev protein with a cis-acting RNA sequence known as the Rev Response Element (RRE) located within the env gene. The RRE forms a stem loop structure that associates with an arginine-rich RNA binding motif (ARM) within Rev.

Literature References
PubMed ID Title Journal Year
2406030 HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence

Malim, MH, Tiley, LS, McCarn, DF, Rusche, JR, Hauber, J, Cullen, BR

Cell 1990
2556643 Sequence-specific RNA binding by the HIV-1 Rev protein

Zapp, ML, Green, MR

Nature 1989
Participants
Participant Of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Reviewed
Created