Rev molecules assemble onto the RRE RNA sequence through their ARM sequence

Stable Identifier
R-HSA-165027
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
nucleoplasm
ReviewStatus
5/5
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Rev molecules assemble onto the RRE RNA sequence through their ARM sequence
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Nuclear export of the unspliced and partially spliced HIV-1 transcripts requires the association of the HIV-1 Rev protein with a cis-acting RNA sequence known as the Rev Response Element (RRE) located within the env gene. The RRE forms a stem loop structure that associates with an arginine-rich RNA binding motif (ARM) within Rev.
Literature References
PubMed ID Title Journal Year
2556643 Sequence-specific RNA binding by the HIV-1 Rev protein

Green, MR, Zapp, ML

Nature 1989
2406030 HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence

Hauber, J, McCarn, DF, Tiley, LS, Cullen, BR, Malim, MH, Rusche, JR

Cell 1990
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Matthews, L  (2005-07-27)
Rice, AP  (2005-07-27)
Reviewed
Kumar, A  (2007-02-01)
Created
Matthews, L  (2005-07-27)
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