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Translocation of nuclear RNA transport complex to cytoplasm
Stable Identifier
R-HSA-165047
Type
Reaction [dissociation]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol
,
nuclear envelope
ReviewStatus
5/5
Locations in the PathwayBrowser
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Rev-mediated nuclear export of HIV RNA (Homo sapiens)
Translocation of nuclear RNA transport complex to cytoplasm (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
Interactions of Rev with host cellular proteins (Homo sapiens)
Rev-mediated nuclear export of HIV RNA (Homo sapiens)
Translocation of nuclear RNA transport complex to cytoplasm (Homo sapiens)
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Crm1 is a nucleocytoplasmic transport factor that is believed to interact with nucleoporins facilitating docking of the RRE-Rev-CRM1-RanGTP complex to the nuclear pore and the translocation of the complex across the nuclear pore complex (see Cullen 1998) Crm1 has been found in complex with two such nucleoporins, CAN/Nup214 and Nup88 which have been shown to be components of the human nuclear pore complex (Fornerod et al., 1997).
Literature References
PubMed ID
Title
Journal
Year
7958838
The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm
Malim, MH
,
Meyer, BE
Genes Dev
1994
11836381
Recruitment of the Crm1 nuclear export factor is sufficient to induce cytoplasmic expression of incompletely spliced human immunodeficiency virus mRNAs
Yi, R
,
Cullen, BR
,
Bogerd, HP
J Virol
2002
Participants
Input
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP:NPC [nuclear envelope]
(Homo sapiens)
Output
Nuclear Pore Complex (NPC) [nuclear envelope]
(Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP [cytosol]
(Homo sapiens)
Participates
as an event of
Rev-mediated nuclear export of HIV RNA (Homo sapiens)
Disease
Name
Identifier
Synonyms
Human immunodeficiency virus infectious disease
DOID:526
HIV infection
Authored
Matthews, L (2005-07-27)
Rice, AP (2005-07-27)
Reviewed
Kumar, A (2007-02-01)
Created
Matthews, L (2005-07-27)
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