Rev-mediated nuclear export of HIV RNA

Stable Identifier
R-HSA-165054
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
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The HIV-1 genome contains 9 genes encoded by a single transcript. In order for the virus to replicate, unspliced, singly-spliced and fully spliced viral mRNA must be exported from the nucleus. The HIV-1 mRNA splice sites are inefficient resulting it the accumulation of a pool of incompletely spliced RNAs (Staffa and Cochrane, 1994). In the early stages of the viral life cycle, or in the absence of the viral Rev protein, completely spliced viral mRNA which encode the regulatory proteins Tat, Nef and Rev are exported from the nucleus while the incompletely spliced structural protein encoding transcripts are held within the nucleus by cellular proteins that normally function in preventing the nuclear export of cellular pre-mRNA. Export of both unspliced and partially spliced mRNA is mediated by the viral protein Rev which is recruited, along with cellular cofactors, to the Rev Response Element (RRE) within the HIV-1 mRNA sequence (Malim et al., 1990; Fischer et al., 1994). The cellular hRIP protein is essential for correct Rev-mediated export of viral RNAs to the cytoplasm (Sanchez-Velar et al., 2004; Yu et al., 2005).

Literature References
PubMed ID Title Journal Year
9791012 Retroviruses as model systems for the study of nuclear RNA export

Cullen, BR

Virology 1998
8805303 HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs

Fritz, CC, Green, MR

Curr Biol 1996
12932730 Nuclear mRNA export: insights from virology

Cullen, BR

Trends Biochem Sci 2003
Participants
Participant Of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Cross References
BioModels Database
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