Formation of TSC1:TSC2 complex

Stable Identifier
R-HSA-165179
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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A membrane-associated TSC1 (hamartin) binds TSC2 (tuberin) and recruits it to the plasma membrane where it can exert its function as a GAP (GTPase activating protein) for the small GTPase RHEB (Cai et al. 2006).

Literature References
PubMed ID Title Journal Year
15589136 Signaling pathways: the benefits of good communication

Fisher, TL, White, MF

Curr Biol 2004
16636147 Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

Cai, SL, Tee, AR, Short, JD, Bergeron, JM, Kim, J, Shen, J, Guo, R, Johnson, CL, Kiguchi, K, Walker, CL

J. Cell Biol. 2006
Participants
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Orthologous Events
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