Phosphorylation of complexed TSC2 by PKB

Stable Identifier
R-HSA-165182
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phosphorylation of complexed TSC2 by PKB
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Phosphorylation of TSC2 by PKB disrupts TSC1:TSC2 heterodimer formation (Hay & Sonenberg 2004) inducing ubiquination and degradation of both TSC1 and TSC2 through the proteosome pathway (Inoki et al. 2002, Dan et al. 2002, Proud 2002). Degradation of TSC2 is not always seen; dissociation of TSC2 from the lysosomal membrane has been suggested as an alternative mechanism (Menon et al. 2014).
Literature References
PubMed ID Title Journal Year
12869586 Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Inoki, K, Guan, KL, Li, Y, Xu, T

Genes Dev 2003
Participants
Input
Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T309,S474-AKT2:PIP3 [plasma membrane]

Physical Entity
p-T309,S474-AKT2:PIP3 [plasma membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of complexed TSC2 by PKB (Bos taurus)
Phosphorylation of complexed TSC2 by PKB (Drosophila melanogaster)
Phosphorylation of complexed TSC2 by PKB (Mus musculus)
Phosphorylation of complexed TSC2 by PKB (Rattus norvegicus)
Phosphorylation of complexed TSC2 by PKB (Schizosaccharomyces pombe)
Phosphorylation of complexed TSC2 by PKB (Sus scrofa)
Authored
Jupe, S  (2015-01-23)
Reviewed
Zwartkruis, FJ  (2015-05-14)
Created
de Bono, B  (2005-08-01)
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