Reactome | RAN [nucleoplasm]

RAN [nucleoplasm]

Stable Identifier

R-HSA-165528

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RAN GTPase

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External Reference Information

External Reference

UniProt:P62826 RAN

Gene Names

RAN, ARA24, OK/SW-cl.81

Chain

initiator methionine:1, chain:2-216

Reference Genes

BioGPS Gene:5901 RAN

COSMIC (genes):RAN RAN

CTD Gene:5901 RAN

dbSNP Gene:5901 RAN

ENSEMBL:ENSG00000132341 RAN

HGNC:9846 RAN

KEGG Gene (Homo sapiens):5901 RAN

Monarch:5901 RAN

NCBI Gene:5901 RAN

OMIM:601179 RAN

UCSC:P62826 RAN

Reference Transcript

Other Identifiers

0007050161

11726279_x_at

11753560_s_at

11758953_s_at

16759202

1839_at

1840_g_at

200749_at

200750_s_at

2901614

2901617

2901618

2901619

3438028

3438029

3438030

3438031

3438033

3438034

3438040

3438041

3438043

3438044

3438045

3438046

3438047

3438048

38708_at

45716_at

5901

7959882

8117888

A_14_P128218

A_23_P128126

A_24_P47547

GE61422

GE80197

GO:0000054

GO:0000055

GO:0000056

GO:0000070

GO:0000166

GO:0000278

GO:0000287

GO:0000785

GO:0003674

GO:0003682

GO:0003723

GO:0003924

GO:0005049

GO:0005515

GO:0005525

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005635

GO:0005643

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005768

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0006259

GO:0006409

GO:0006606

GO:0006611

GO:0006629

GO:0006810

GO:0006913

GO:0007010

GO:0007049

GO:0007052

GO:0007059

GO:0007084

GO:0008150

GO:0009058

GO:0010586

GO:0015031

GO:0016020

GO:0016032

GO:0019003

GO:0030496

GO:0031410

GO:0032092

GO:0032991

GO:0034641

GO:0035281

GO:0042254

GO:0042307

GO:0042470

GO:0042565

GO:0043167

GO:0043226

GO:0043657

GO:0044281

GO:0044403

GO:0045296

GO:0045540

GO:0046039

GO:0046872

GO:0046982

GO:0051276

GO:0051301

GO:0055037

GO:0061015

GO:0061024

GO:0070062

GO:0070883

GO:0075733

GO:0140014

GO:1902570

HMNXSV003031581

Hs.10842.0.A3_3p_at

ILMN_1757384

ILMN_3307930

PH_hs_0001070

TC12001038.hg

g4092053_3p_a_at

g4092053_3p_x_at

Participates

as a component of

Other forms of this molecule

RAN [cytosol]

Inferred To

Homologues of RAN [nucleoplasm] (Bos taurus)

RAN [nucleoplasm] (Bos taurus)

RAN [nucleoplasm] (Gallus gallus)

RAN [nucleoplasm] (Plasmodium falciparum)

RAN [nucleoplasm] (Sus scrofa)

GSP1 [nucleoplasm] (Saccharomyces cerevisiae)

ran [nucleoplasm] (Danio rerio)

ran [nucleoplasm] (Xenopus tropicalis)

Ran [nucleoplasm] (Drosophila melanogaster)

Ran [nucleoplasm] (Mus musculus)

Ran [nucleoplasm] (Rattus norvegicus)

ranA [nucleoplasm] (Dictyostelium discoideum)

ran-1 [nucleoplasm] (Caenorhabditis elegans)

spi1 [nucleoplasm] (Schizosaccharomyces pombe)

LOC100686305 [nucleoplasm] (Canis familiaris)

Cross References

RefSeq

NP_001287725.1, NP_006316.1, NP_001287726.1

OpenTargets

ENSG00000132341

GeneCards

P62826

HPA

ENSG00000132341-RAN

Ensembl

ENST00000543796, ENSP00000446215, ENSG00000132341, ENST00000392369, ENSP00000376176

PRO

P62826

Pharos - Targets

P62826

GlyGen

P62826

HMDB Protein

HMDBP01769

PDB

1RRP, 5UWP, 5UWO, 6X2Y, 5UWR, 3GJ6, 5CJ2, 5CIW, 3GJ7, 4C0Q, 4HAW, 6CIT, 3CH5, 5UWH, 1QBK, 6X2V, 4GMX, 4HAY, 6XJP, 5UWU, 3NC1, 5CLL, 6X2W, 3GJ0, 3ZJY, 3GJ3, 6A3A, 5UWW, 6X2U, 4HAZ, 2N1B, 4OL0, 3GJX, 6XJT, 6X2P, 1K5G, 4HAU, 4HB4, 6KFT, 3EA5, 6XJU, 4HB3, 5YST, 5DHF, 6A3B, 1I2M, 5DI9, 6X2X, 6X2O, 2MMC, 6TVO, 2MMG, 5UWJ, 5DIF, 5CIT, 6X2S, 5CLQ, 5CIQ, 3GJ5, 4GPT, 5DIS, 7L5E, 6X2M, 5UWQ, 5YRO, 3GJ8, 3NBY, 4HAV, 6A38, 5DLQ, 5DH9, 4WVF, 5UWT, 4HAX, 5ZPU, 4HB2, 4HB0, 3GJ4, 1K5D, 5DHA, 5JLJ, 6Q84, 6A3C, 5YSU, 1IBR, 6X2R, 6Q82, 5FYQ, 4HAT, 5YTB, 6XJR, 3NC0, 5UWI, 6XJS, 3NBZ, 6A3E, 5UWS

Interactors (35)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18754 RCC1	2	RCC1 [nucleoplasm] (R-HSA-180690) RCC1 [chromosome] (R-HSA-9668547)	0.88	15
GDP [ChEBI:17552]	7	GDP [plasma membrane] (R-ALL-114549) GDP [cytoplasmic vesicle membrane] (R-ALL-1996292) GDP [platelet dense granule lumen] (R-ALL-114622) GDP [cilium] (R-ALL-5617810) GDP [lysosomal membrane] (R-ALL-9628545) GDP [nucleoplasm] (R-ALL-111349) GDP [endoplasmic reticulum lumen] (R-ALL-1467290)	0.806	7
UniProt:P49792 RANBP2	6	RANBP2(1-867)-ALK(1058-1620) fusion [cytosol] (R-HSA-9702002) RANBP2 [nuclear envelope] (R-HSA-2993756) RANBP2(1-867)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9718443) RANBP2 [cytosol] (R-HSA-157703) SUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720) SUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599)	0.764	4
GTP [ChEBI:15996]	7	GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cilium] (R-ALL-5617813) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [Golgi membrane] (R-ALL-1806221) GTP [early endosome membrane] (R-ALL-2130170) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [lysosomal membrane] (R-ALL-2213216)	0.761	9
UniProt:Q6P5F9	2	Xpo1 [nucleoplasm] (R-MMU-165529) Xpo1 [cytosol] (R-MMU-165539)	0.676	3
UniProt:Q8WUF5 PPP1R13L	1	PPP1R13L [nucleoplasm] (R-HSA-6799738)	0.65	9
UniProt:O15392 BIRC5	3	BIRC5 [nucleoplasm] (R-HSA-4655344) BIRC5 [cytosol] (R-HSA-50851) ub-BIRC5 [cytosol] (R-HSA-8955933)	0.635	7
UniProt:P43487 RANBP1	1	RANBP1 [nuclear envelope] (R-HSA-167651)	0.609	3
UniProt:P47813 EIF1AX	1	EIF1AX [cytosol] (R-HSA-72557)	0.591	3
UniProt:Q9ERU9 Ranbp2	5	Ranbp2 [nuclear envelope] (R-MMU-4551599) Ranbp2 [nuclear envelope] (R-MMU-4551720) Ranbp2 [nuclear envelope] (R-MMU-2993756) Ranbp2 [nuclear envelope] (R-MMU-5228524) Ranbp2 [cytosol] (R-MMU-157703)	0.564	2
UniProt:Q13901 C1D	1	C1D [nucleoplasm] (R-HSA-6791515)	0.556	3
UniProt:O43592 XPOT	2	XPOT [cytosol] (R-HSA-6783484) XPOT [nucleoplasm] (R-HSA-6783465)	0.556	3
UniProt:Q06547-3 GABPB1	1	NRF2 gamma-1 subunit [nucleoplasm] (R-HSA-1592216)	0.556	3
UniProt:Q9H0Y0 ATG10	2	GlyK166-ATG10 [cytosol] (R-HSA-5683572) ATG10 [cytosol] (R-HSA-5671733)	0.556	3
UniProt:Q86WV5 TEN1	1	TEN1 [nucleoplasm] (R-HSA-9668823)	0.556	3
UniProt:P06241 FYN	6	MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) p-Y420-FYN [cytosol] (R-HSA-391821) FYN [cytosol] (R-HSA-200917) p-Y531-FYN [cytosol] (R-HSA-391819) p-S21,Y420-FYN [cytosol] (R-HSA-5218745) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873)	0.556	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) CTNNB1 S45F [cytosol] (R-HSA-4791268) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45P [cytosol] (R-HSA-4791272) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619)	0.556	3
UniProt:Q9BQA1 WDR77	3	pT5-WDR77 [nucleoplasm] (R-HSA-5205602) WDR77 [nucleoplasm] (R-HSA-5205610) WDR77 [cytosol] (R-HSA-191823)	0.556	3
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.556	3
UniProt:P37840 SNCA	4	SNCA [cytosol] (R-HSA-5658500) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569) Ub-SNCA [cytosol] (R-HSA-5660754)	0.556	3
UniProt:Q86US8 SMG6	1	SMG6 [cytosol] (R-HSA-927851)	0.556	3
UniProt:Q14032 BAAT	2	BAAT [cytosol] (R-HSA-159392) BAAT [peroxisomal matrix] (R-HSA-193517)	0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:Q8WUX9 CHMP7	2	CHMP7 [endosome membrane] (R-HSA-9631168) CHMP7 [cytosol] (R-HSA-917703)	0.556	3
UniProt:Q04206 RELA	6	SUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) RELA [nucleoplasm] (R-HSA-177676) p-S276-RELA [nucleoplasm] (R-HSA-5624468)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:Q12888 TP53BP1	3	SUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.556	3
UniProt:Q07869 PPARA	2	PPARA [nucleoplasm] (R-HSA-400186) SUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099)	0.556	3
UniProt:O15534 PER1	4	PER1 [cytosol] (R-HSA-400373) p-S-PER1 [nucleoplasm] (R-HSA-3325590) Ub-p-S-PER1 [cytosol] (R-HSA-517831) p-S-PER1 [cytosol] (R-HSA-400310)	0.556	3
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:O95674 CDS2	1	CDS2 [mitochondrial inner membrane] (R-HSA-1498755)	0.556	3
UniProt:P13569 CFTR	17	CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR [plasma membrane] (R-HSA-383188) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR [endosome membrane] (R-HSA-6782965) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) CFTR N1303K [plasma membrane] (R-HSA-5678983) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) ub-CFTR F508del [cytosol] (R-HSA-8866838) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	10
UniProt:Q14974 KPNB1	5	KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [cytosol] (R-HSA-180733)	0.527	2
UniProt:P63279 UBE2I	8	SUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [nuclear envelope] (R-HSA-4655408) UBE2I [cytosol] (R-HSA-4655342) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481)	0.527	2
UniProt:P42771 CDKN2A	20	p16INK4A V126D [cytosol] (R-HSA-9631055) p16INK4A P81L [cytosol] (R-HSA-9632280) p16INK4A P114L [cytosol] (R-HSA-9630916) p16INK4A P81R [cytosol] (R-HSA-9632294) p16INK4A R58* [cytosol] (R-HSA-9632582) p16INK4A W110* [cytosol] (R-HSA-9632585) p16INK4A D84H [cytosol] (R-HSA-9632489) p16INK4A D84N [cytosol] (R-HSA-9632483) p16INK4A A20P [cytosol] (R-HSA-9630805) p16INK4A D84G [cytosol] (R-HSA-9632461) p16INK4A D84Y [cytosol] (R-HSA-9632478) p16INK4A P81T [cytosol] (R-HSA-9632275) p16INK4A M53I [cytosol] (R-HSA-9630911) p16INK4A D84V [cytosol] (R-HSA-9632465) p16INK4A D84A [cytosol] (R-HSA-9632486) p16INK4A R80* [cytosol] (R-HSA-9632586) p16INK4A G101W [cytosol] (R-HSA-9631257) p16INK4A R87P [cytosol] (R-HSA-9632335) p16INK4A E88* [cytosol] (R-HSA-9632588) p16INK4A P81H [cytosol] (R-HSA-9632293)	0.463	2

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