Reactome | RAN [nucleoplasm]

RAN [nucleoplasm]

Stable Identifier

R-HSA-165528

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RAN GTPase

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P62826 RAN

Gene Names

RAN, ARA24, OK/SW-cl.81

Chain

initiator methionine:1, chain:2-216

Reference Genes

BioGPS Gene:5901 RAN

COSMIC (genes):RAN RAN

CTD Gene:5901 RAN

dbSNP Gene:5901 RAN

ENSEMBL:ENSG00000132341 RAN

HGNC:9846 RAN

KEGG Gene (Homo sapiens):5901 RAN

Monarch:5901 RAN

NCBI Gene:5901 RAN

OMIM:601179 RAN

UCSC:P62826 RAN

Reference Transcript

Other Identifiers

0007050161

11726279_x_at

11753560_s_at

11758953_s_at

16759202

1839_at

1840_g_at

1I2M

1IBR

1K5D

1K5G

1QBK

1RRP

200749_at

200750_s_at

2901614

2901617

2901618

2901619

2MMC

2MMG

2N1B

3438028

3438029

3438030

3438031

3438033

3438034

3438040

3438041

3438043

3438044

3438045

3438046

3438047

3438048

38708_at

3CH5

3EA5

3GJ0

3GJ3

3GJ4

3GJ5

3GJ6

3GJ7

3GJ8

3GJX

3NBY

3NBZ

3NC0

3NC1

3ZJY

45716_at

4C0Q

4GMX

4GPT

4HAT

4HAU

4HAV

4HAW

4HAX

4HAY

4HAZ

4HB0

4HB2

4HB3

4HB4

4OL0

4WVF

5901

5CIQ

5CIT

5CIW

5CJ2

5CLL

5CLQ

5DH9

5DHA

5DHF

5DI9

5DIF

5DIS

5DLQ

5FYQ

5JLJ

5UWH

5UWI

5UWJ

5UWO

5UWP

5UWQ

5UWR

5UWS

5UWT

5UWU

5UWW

5YRO

5YST

5YSU

5YTB

63353

6CIT

7959882

8117888

A0A087X0W0

A_14_P128218

A_23_P128126

A_24_P47547

AAA36546

AAC05840

AAC99400

AAH04272

AAH14518

AAH14901

AAH16654

AAH51908

AAH72000

AAM15923

AAP35935

AB062399

AF052578

AF054183

AF501887

AK290763

AK312466

B4DV51

B5MDF5

BAB93486

BAF83452

BAG35373

BC004272

BC014518

BC014901

BC016654

BC051908

BC072000

BT007271

CAG29343

CCDS9271

CH471054

CR450347

EAW98516

ENSG00000132341

ENSP00000376176

ENSP00000446215

ENST00000392369

ENST00000392369.6

ENST00000543796

ENST00000543796.5

EntrezGene:5901

EntrezGene:RAN

F5H018

g4092053_3p_a_at

g4092053_3p_x_at

GE61422

GE80197

GO:0000055

GO:0000056

GO:0000070

GO:0000166

GO:0000278

GO:0000287

GO:0000785

GO:0003674

GO:0003682

GO:0003723

GO:0003924

GO:0005049

GO:0005515

GO:0005525

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005643

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005768

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0006259

GO:0006409

GO:0006606

GO:0006611

GO:0006629

GO:0006810

GO:0006913

GO:0007010

GO:0007049

GO:0007052

GO:0007059

GO:0007165

GO:0008134

GO:0008150

GO:0009058

GO:0010586

GO:0015031

GO:0016020

GO:0016032

GO:0019003

GO:0030496

GO:0030521

GO:0031410

GO:0032092

GO:0032991

GO:0034641

GO:0035281

GO:0042254

GO:0042307

GO:0042470

GO:0042565

GO:0043167

GO:0043226

GO:0043657

GO:0044281

GO:0044403

GO:0045296

GO:0045540

GO:0045893

GO:0046039

GO:0046872

GO:0046982

GO:0050681

GO:0051276

GO:0051301

GO:0055037

GO:0061015

GO:0070062

GO:0070883

GO:0075733

GO:0140014

GO:1902570

HGNC:9846

HPA063353

Hs.10842.0.A3_3p_at

ILMN_1757384

ILMN_3307930

IPR001806

IPR002041

IPR005225

IPR027417

J3KQE5

M31469

MIM:601179

NM_006325

NP_006316

PF00071

PH_hs_0001070

PR00627

RAN

RAN-202

RAN-212

SM00173

SM00174

SM00175

SM00176

TC12001038.hg

UPI0000000DE2

Participant Of

hasComponent

Other forms of this molecule

RAN [cytosol]

Inferred To

Homologues of RAN [nucleoplasm] (Bos taurus)

RAN [nucleoplasm] (Bos taurus)

RAN [nucleoplasm] (Caenorhabditis elegans)

RAN [nucleoplasm] (Canis familiaris)

RAN [nucleoplasm] (Danio rerio)

RAN [nucleoplasm] (Dictyostelium discoideum)

RAN [nucleoplasm] (Drosophila melanogaster)

RAN [nucleoplasm] (Gallus gallus)

RAN [nucleoplasm] (Mus musculus)

RAN [nucleoplasm] (Plasmodium falciparum)

RAN [nucleoplasm] (Rattus norvegicus)

RAN [nucleoplasm] (Saccharomyces cerevisiae)

RAN [nucleoplasm] (Schizosaccharomyces pombe)

RAN [nucleoplasm] (Sus scrofa)

RAN [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_006316.1, NP_001287725.1, NP_001287726.1

OpenTargets

ENSG00000132341

GeneCards

P62826

PRO

P62826

HMDB Protein

HMDBP01769

PDB

6A3E, 5UWH, 4OL0, 5YTB, 5UWI, 3GJX, 5DIS, 2N1B, 1K5G, 2MMC, 5CLL, 5FYQ, 6A3C, 6A3B, 5YSU, 1RRP, 1I2M, 1IBR, 4GMX, 5DIF, 5ZPU, 4WVF, 3NC1, 3GJ0, 4HAX, 3NBZ, 4HAW, 1QBK, 5DH9, 5YST, 5DLQ, 4HAZ, 3GJ3, 4HAY, 5JLJ, 5UWW, 1K5D, 5CLQ, 3ZJY, 3GJ4, 4HAU, 4GPT, 4HB4, 3EA5, 4HB3, 3GJ5, 5UWT, 5CJ2, 4HAT, 3GJ6, 5UWU, 5DI9, 4C0Q, 3NBY, 3GJ7, 5UWR, 3NC0, 6CIT, 3CH5, 3GJ8, 5YRO, 4HAV, 5UWS, 6A3A, 6Q82, 5CIQ, 6Q84, 5UWP, 2MMG, 5UWQ, 5CIW, 4HB2, 5DHF, 5CIT, 4HB0, 6A38, 5UWJ, 5DHA, 5UWO

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18754 RCC1	1	RCC1 [nucleoplasm] (R-HSA-180690)	0.88	15
GDP [ChEBI:17552]	12	GDP [cytoplasmic vesicle membrane] (R-ALL-1996292) GDP [lysosomal membrane] (R-ALL-9628545) GDP [cilium] (R-ALL-5617810) GDP [platelet dense granule lumen] (R-ALL-114622) GDP [nucleoplasm] (R-ALL-111349) GDP [extracellular region] (R-ALL-114623) GDP [endocytic vesicle lumen] (R-ALL-8851528) GDP [Golgi lumen] (R-ALL-205689) GDP [endoplasmic reticulum lumen] (R-ALL-1467290) GDP [plasma membrane] (R-ALL-114549) GDP [mitochondrial matrix] (R-ALL-113525) GDP [cytosol] (R-ALL-29420)	0.806	7
UniProt:P49792 RANBP2	4	SUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599) SUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720) RANBP2 [cytosol] (R-HSA-157703) RANBP2 [nuclear envelope] (R-HSA-2993756)	0.764	4
GTP [ChEBI:15996]	13	GTP [early endosome membrane] (R-ALL-2130170) GTP [cilium] (R-ALL-5617813) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [extracellular region] (R-ALL-114626) GTP [Golgi lumen] (R-ALL-8851242) GTP [endocytic vesicle lumen] (R-ALL-8851508) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [mitochondrial matrix] (R-ALL-113573) GTP [Golgi membrane] (R-ALL-1806221) GTP [nucleoplasm] (R-ALL-113571) GTP [cytosol] (R-ALL-29438)	0.761	9
UniProt:Q6P5F9	2	XPO1 [cytosol] (R-MMU-165539) XPO1 [nucleoplasm] (R-MMU-165529)	0.676	3
UniProt:Q8WUF5 PPP1R13L	1	PPP1R13L [nucleoplasm] (R-HSA-6799738)	0.65	9
UniProt:O15392 BIRC5	3	BIRC5 [cytosol] (R-HSA-50851) ub-BIRC5 [cytosol] (R-HSA-8955933) BIRC5 [nucleoplasm] (R-HSA-4655344)	0.645	7
UniProt:P43487 RANBP1	1	RANBP1 [nuclear envelope] (R-HSA-167651)	0.609	3
UniProt:P47813 EIF1AX	1	EIF1AX [cytosol] (R-HSA-72557)	0.591	3
UniProt:Q9ERU9 Ranbp2	5	SUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-MMU-4551599) SUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-MMU-4551720) Ranbp2 [nuclear envelope] (R-MMU-5228524) RANBP2 [nuclear envelope] (R-MMU-2993756) RANBP2 [cytosol] (R-MMU-157703)	0.564	2
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [specific granule lumen] (R-HSA-6799646)	0.527	2
UniProt:P63279 UBE2I	8	SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) UBE2I [cytosol] (R-HSA-4655342) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617)	0.527	2
UniProt:O43592 XPOT	2	XPOT [nucleoplasm] (R-HSA-6783465) XPOT [cytosol] (R-HSA-6783484)	0.488	2
UniProt:P42771 CDKN2A	80	p16INK4A E88* [cytosol] (R-HSA-9632588) p16INK4A D84G [cytosol] (R-HSA-9632461) p16INK4A R87P [cytosol] (R-HSA-9632335) p16INK4A V126D [cytosol] (R-HSA-9631055) p16INK4A W110* [cytosol] (R-HSA-9632585) p16INK4A D84H [cytosol] (R-HSA-9632489) p16INK4A R80* [cytosol] (R-HSA-9632586) p16INK4A P114L [cytosol] (R-HSA-9630916) p16INK4A R58* [cytosol] (R-HSA-9632582) p16INK4A D84N [cytosol] (R-HSA-9632483) p16INK4A M53I [cytosol] (R-HSA-9630911) p16INK4A D84Y [cytosol] (R-HSA-9632478) p16INK4A G101W [cytosol] (R-HSA-9631257) p16INK4A P81L [cytosol] (R-HSA-9632280) p16INK4A A20P [cytosol] (R-HSA-9630805) p16INK4A D84V [cytosol] (R-HSA-9632465) p16INK4A P81T [cytosol] (R-HSA-9632275) p16INK4A P81H [cytosol] (R-HSA-9632293) p16INK4A D84A [cytosol] (R-HSA-9632486) p16INK4A P81R [cytosol] (R-HSA-9632294) p16INK4A E10* [cytosol] (R-HSA-9648382) p16INK4A S12* [cytosol] (R-HSA-9648383) p16INK4A P114T [cytosol] (R-HSA-9631034) p16INK4A P114S [cytosol] (R-HSA-9631027) p16INK4A G23fs3 [cytosol] (R-HSA-9648652) p16INK4A E61 [cytosol] (R-HSA-9648396) p16INK4A A20T [cytosol] (R-HSA-9630861) p16INK4A A36fs17 [cytosol] (R-HSA-9648653) p16INK4A E69 [cytosol] (R-HSA-9648397) p16INK4A W15fs1 [cytosol] (R-HSA-9648654) p16INK4A Y44 [cytosol] (R-HSA-9648398) p16INK4A T18fs15 [cytosol] (R-HSA-9648655) p16INK4A E26 [cytosol] (R-HSA-9648392) p16INK4A E33* [cytosol] (R-HSA-9648393) p16INK4A Q50* [cytosol] (R-HSA-9648394) p16INK4A E120* [cytosol] (R-HSA-9632587) p16INK4A S7fs8 [cytosol] (R-HSA-9648651) p16INK4A W15 [cytosol] (R-HSA-9648395) p16INK4A P75* [cytosol] (R-HSA-9648388) p16INK4A C72* [cytosol] (R-HSA-9648389) p16INK4A E119* [cytosol] (R-HSA-9648390) p16INK4A A20E [cytosol] (R-HSA-9630855) p16INK4A N39fs14 [cytosol] (R-HSA-9648647) p16INK4A P114R [cytosol] (R-HSA-9631046) p16INK4A P114H [cytosol] (R-HSA-9631043) p16INK4A E27 [cytosol] (R-HSA-9648387) p16INK4A P81S [cytosol] (R-HSA-9632287) p16INK4A G101V [cytosol] (R-HSA-9631263) p16INK4A Y44fs1 [cytosol] (R-HSA-9648664) p16INK4A V126I [cytosol] (R-HSA-9631130) p16INK4A L16fs9 [cytosol] (R-HSA-9648663) p16INK4A V126A [cytosol] (R-HSA-9631126) p16INK4A T18fs8 [cytosol] (R-HSA-9648656) p16INK4A V126F [cytosol] (R-HSA-9631120) p16INK4A L37fs16 [cytosol] (R-HSA-9648659) p16INK4A G35V [cytosol] (R-HSA-9631308) p16INK4A G23D [cytosol] (R-HSA-9630892) p16INK4A R24P [cytosol] (R-HSA-9630828) p16INK4A R80P [cytosol] (R-HSA-9632270) p16INK4A G35A [cytosol] (R-HSA-9631306) p16INK4A E88K [cytosol] (R-HSA-9632548) p16INK4A T77P [cytosol] (R-HSA-9632257) p16INK4A L97R [cytosol] (R-HSA-9632512) p16INK4A T18_A19dup [cytosol] (R-HSA-9632192) p16INK4A G67_N71del [cytosol] (R-HSA-9632252) p16INK4A A60R [cytosol] (R-HSA-9632216) p16INK4A D74Y [cytosol] (R-HSA-9632088) p16INK4A A60V [cytosol] (R-HSA-9632212) p16INK4A R112_L113insR [cytosol] (R-HSA-9632566) p16INK4A R99P [cytosol] (R-HSA-9632531) p16INK4A [cytosol] (R-HSA-182578) p16INK4A G35E [cytosol] (R-HSA-9631314) p16INK4A G35W [cytosol] (R-HSA-9631328) p16INK4A T77S [cytosol] (R-HSA-9632256) p16INK4A G35R [cytosol] (R-HSA-9631316) p16INK4A G23V [cytosol] (R-HSA-9631157) p16INK4A A60E [cytosol] (R-HSA-9632202) p16INK4A G23S [cytosol] (R-HSA-9631163) p16INK4A L97P [cytosol] (R-HSA-9632523) p16INK4A A60S [cytosol] (R-HSA-9632206)	0.463	2