Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1)

Stable Identifier
R-HSA-1655848
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1)
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The HMGCS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
Literature References
PubMed ID Title Journal Year
12177166 Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes

Matsuzaka, T, Amemiya-Kudo, M, Ohashi, K, Yamada, N, Kimura, S, Tamura, Y, Yoshikawa, T, Yahagi, N, Harada, K, Iizuka, Y, Okazaki, H, Shimano, H, Ishibashi, S, Sato, R, Gotoda, T, Hasty, AH, Osuga, J

J Lipid Res 2002
19088433 Transcriptional regulation of HMG-CoA synthase and HMG-CoA reductase genes by human ACBP

Nitz, I, Döring, F, Vock, C

Cell Physiol Biochem 2008
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Regulator
SREBP1A,1C,2:NF-Y:HMGCS1 gene [nucleoplasm] (Homo sapiens)
Authored
May, B  (2011-09-28)
Reviewed
Liang, G  (2012-08-26)
Kersten, S  (2009-06-08)
Created
May, B  (2011-10-13)
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