Thiosulfate can transfer its sulfur atom to glutathione

Stable Identifier
R-HSA-1655879
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Thiosulfate is able to transfer its sulfur atom to glutathione, a reaction investigated in yeast (Chauncey & Westley 1983). Recombinant human thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1 (TSTD1 aka KAT1) (and its yeast equivalent RDL1) catalyse a predicted thiosulfate-dependent conversion of glutathione (GSH) to glutathione disulfide (GSSG) (Melideo et al. 2014).
Literature References
PubMed ID Title Journal Year
24981631 Biosynthesis of a central intermediate in hydrogen sulfide metabolism by a novel human sulfurtransferase and its yeast ortholog

Melideo, SL, Jorns, MS, Jackson, MR

Biochemistry 2014
6361026 The catalytic mechanism of yeast thiosulfate reductase

Chauncey, TR, Westley, J

J Biol Chem 1983
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Catalyst Activity

thiosulfate-thiol sulfurtransferase activity of TSTD1 [cytosol]

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