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Our Logo
License Agreement
Privacy Notice
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Table of Contents
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MTOR [cytosol]
Stable Identifier
R-HSA-165662
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
mTOR
Icon
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Active MTORC1 binds the ULK1 complex (Homo sapiens)
MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
Active MTORC1 phosphorylates ULK1 (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
MTORC1 dissociates from ULK complex (Homo sapiens)
MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
MTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Homo sapiens)
mTORC1 with p-S722,S792-RPTOR [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
MTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Homo sapiens)
mTORC1 with p-S722,S792-RPTOR [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
Rheb in the MTORC1 complex hydrolyses GTP (Homo sapiens)
MTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Homo sapiens)
MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
MTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Homo sapiens)
mTORC1 with p-S722,S792-RPTOR [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Amino acids regulate mTORC1 (Homo sapiens)
RRAGA,B hydrolyzes GTP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
mTORC1 binds RHEB:GTP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by AKT1 E17K in Cancer (Homo sapiens)
AKT1 E17K mutant is phosphorylated by TORC2 complex (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
TORC2 complex [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Degradation (Homo sapiens)
TORC2 complex phosphorylates SGK1 (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
TORC2 complex [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CD28 co-stimulation (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
TORC2 complex [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
MAF1 translocates to the nucleus (Homo sapiens)
MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
mTORC1 phosphorylates MAF1 (Homo sapiens)
MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
TORC2 complex [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
MTOR signalling (Homo sapiens)
AKT1S1 (PRAS40) binds mTORC1 (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Homo sapiens)
mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
Energy dependent regulation of mTOR by LKB1-AMPK (Homo sapiens)
AMPK phosphorylates Raptor in the mTORC1 complex (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Homo sapiens)
mTORC1 with p-S722,S792-RPTOR [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
Formation of active mTORC1 complex (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
Phosphorylated AKT1S1:mTORC1 binds YWHAB (Homo sapiens)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
mTORC1 phosphorylates AKT1S1 (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
mTORC1-mediated signalling (Homo sapiens)
Phosphorylation of 4E-BP1 by activated mTORC1 (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
mTORC1 phosphorylation of RPS6KB1 (S6K) (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Homo sapiens)
mTORC1 with p-S722,S792-RPTOR [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
mTORC1 [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated vascular permeability (Homo sapiens)
TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
TORC2 complex [cytosol] (Homo sapiens)
MTOR [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42345 MTOR
Gene Names
MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1
Chain
chain:1-2549
Reference Genes
BioGPS Gene:2475 MTOR
COSMIC (genes):MTOR MTOR
CTD Gene:2475 MTOR
dbSNP Gene:2475 MTOR
ENSEMBL:ENSG00000198793 MTOR
HGNC:3942 MTOR
KEGG Gene (Homo sapiens):2475 MTOR
Monarch:2475 MTOR
NCBI Gene:2475 MTOR
OMIM:601231 MTOR
UCSC:P42345 MTOR
Reference Transcript
RefSeq:XM_005263438.2 MTOR
RefSeq:NM_004958.3 MTOR
Other Identifiers
0003190369
11716133_a_at
11716134_a_at
11750567_a_at
16681661
202288_at
2396538
2396539
2396540
2396541
2396542
2396543
2396544
2396545
2396547
2396548
2396550
2396552
2396555
2396556
2396557
2396560
2396561
2396562
2396563
2396565
2396567
2396569
2396570
2396571
2396572
2396576
2396577
2396580
2396581
2396582
2396584
2396586
2396587
2396588
2396589
2396598
2396599
2396600
2396603
2396604
2396605
2396606
2396607
2396609
2396610
2396611
2396612
2396613
2396614
2396615
2396616
2396617
2396618
2396619
2396620
2396622
2396623
2396625
2396628
2396629
2396633
2396635
2396637
2475
267_at
40139_at
7912412
A_23_P34606
GE81461
GO:0000003
GO:0000139
GO:0000166
GO:0001002
GO:0001003
GO:0001006
GO:0001156
GO:0001558
GO:0001932
GO:0001933
GO:0001934
GO:0001938
GO:0002296
GO:0002376
GO:0003007
GO:0003013
GO:0003179
GO:0003674
GO:0003677
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005635
GO:0005654
GO:0005737
GO:0005739
GO:0005741
GO:0005764
GO:0005765
GO:0005773
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0005975
GO:0005979
GO:0006091
GO:0006109
GO:0006112
GO:0006207
GO:0006412
GO:0006464
GO:0006468
GO:0006629
GO:0006810
GO:0006914
GO:0006950
GO:0007010
GO:0007040
GO:0007049
GO:0007050
GO:0007165
GO:0007267
GO:0007281
GO:0007420
GO:0007568
GO:0007569
GO:0007584
GO:0007616
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0008361
GO:0008542
GO:0009056
GO:0009058
GO:0009267
GO:0009791
GO:0010506
GO:0010507
GO:0010592
GO:0010628
GO:0010718
GO:0010831
GO:0010942
GO:0010976
GO:0012505
GO:0014042
GO:0014736
GO:0014823
GO:0016020
GO:0016241
GO:0016242
GO:0016301
GO:0016310
GO:0016605
GO:0016740
GO:0018105
GO:0018107
GO:0019899
GO:0019901
GO:0019904
GO:0021510
GO:0021700
GO:0022607
GO:0030030
GO:0030154
GO:0030163
GO:0030425
GO:0030838
GO:0031090
GO:0031397
GO:0031410
GO:0031529
GO:0031641
GO:0031667
GO:0031669
GO:0031929
GO:0031931
GO:0031932
GO:0031998
GO:0032095
GO:0032148
GO:0032516
GO:0032868
GO:0032956
GO:0032991
GO:0034198
GO:0034641
GO:0034655
GO:0035176
GO:0035264
GO:0038202
GO:0040007
GO:0040011
GO:0042060
GO:0042220
GO:0042752
GO:0042802
GO:0043022
GO:0043025
GO:0043087
GO:0043167
GO:0043200
GO:0043226
GO:0043231
GO:0043276
GO:0043278
GO:0043610
GO:0044281
GO:0044877
GO:0045182
GO:0045335
GO:0045429
GO:0045670
GO:0045727
GO:0045792
GO:0045859
GO:0045945
GO:0046777
GO:0046889
GO:0048255
GO:0048511
GO:0048661
GO:0048714
GO:0048738
GO:0048856
GO:0048870
GO:0050731
GO:0050769
GO:0050877
GO:0050882
GO:0051219
GO:0051496
GO:0051549
GO:0051647
GO:0051896
GO:0051897
GO:0055006
GO:0055013
GO:0055085
GO:0060048
GO:0060135
GO:0060252
GO:0060999
GO:0061051
GO:0065003
GO:0070885
GO:0071230
GO:0071233
GO:0071456
GO:0090335
GO:0090559
GO:0098978
GO:0099524
GO:0099547
GO:0106310
GO:0106311
GO:1900034
GO:1901216
GO:1901838
GO:1903691
GO:1904000
GO:1904056
GO:1904058
GO:1904059
GO:1904193
GO:1904197
GO:1904206
GO:1904213
GO:1904690
GO:1990253
HMNXSV003015930
HMNXSV003049665
ILMN_1769031
L34075_at
PH_hs_0016579
TC01002197.hg
g3282238_3p_at
Participates
as a component of
mTORC1 [cytosol] (Homo sapiens)
mTORC1 with p-S722,S792-RPTOR [cytosol] (Homo sapiens)
TORC2 complex [cytosol] (Homo sapiens)
Other forms of this molecule
MTOR [nucleoplasm]
Inferred To
MTOR [cytosol]
(Canis familiaris)
MTOR [cytosol]
(Danio rerio)
MTOR [cytosol]
(Gallus gallus)
MTOR [cytosol]
(Sus scrofa)
Homologues of MTOR [cytosol]
(Danio rerio)
Homologues of MTOR [cytosol]
(Saccharomyces cerevisiae)
tor2 [cytosol]
(Schizosaccharomyces pombe)
Ghost homologue of MTOR [cytosol]
(Bos taurus)
TOR2 [cytosol]
(Saccharomyces cerevisiae)
Tor [cytosol]
(Drosophila melanogaster)
tor [cytosol]
(Dictyostelium discoideum)
let-363 [cytosol]
(Caenorhabditis elegans)
mtor [cytosol]
(Danio rerio)
Mtor [cytosol]
(Mus musculus)
Mtor [cytosol]
(Rattus norvegicus)
TOR1 [cytosol]
(Saccharomyces cerevisiae)
Cross References
RefSeq
XP_005263495.1
,
NP_004949.1
ZINC - World Drugs
MTOR_HUMAN
OpenTargets
ENSG00000198793
ZINC - FDA approved
MTOR_HUMAN
ZINC - Substances
MTOR_HUMAN
ZINC target
P42345
PRO
P42345
PDB
4DRH
,
2NPU
,
1AUE
,
5WBY
,
4JSN
,
3JBZ
,
6BCX
,
5H64
,
5WBU
,
4JT6
,
4JSX
,
5GPG
,
6M4U
,
4JT5
,
5FLC
,
6M4W
,
6BCU
,
5ZCS
,
1NSG
,
4JSV
,
5WBH
,
2RSE
,
6SB2
,
2GAQ
,
1FAP
,
3FAP
,
4DRJ
,
4DRI
,
6SB0
,
4FAP
,
4JSP
,
2FAP
ZINC - Investigational
MTOR_HUMAN
IntEnz
2.7.11.1
GeneCards
P42345
HPA
ENSG00000198793-MTOR
Ensembl
ENST00000361445
,
ENSP00000354558
,
ENSG00000198793
ZINC - Predictions - Purchasable
MTOR_HUMAN
Orphanet
23236
HMDB Protein
HMDBP02611
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62942 FKBP1A
1
FKBP1A [cytosol]
(R-HSA-2026007)
0.786
5
UniProt:P31749 AKT1
13
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
0.731
4
UniProt:O75385 ULK1
7
ULK1 [cytosol]
(R-HSA-1632847)
ULK1 [recycling endosome]
(R-HSA-8854761)
ULK1 [mitochondrial outer membrane]
(R-HSA-8948145)
p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane]
(R-HSA-8948047)
p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol]
(R-HSA-5675858)
p-S317,467,556,638,T575-ULK1 [cytosol]
(R-HSA-5673747)
p-S758-ULK1 [cytosol]
(R-HSA-5672131)
0.702
7
UniProt:Q96B36 AKT1S1
5
p-S183,T246-AKT1S1 [cytosol]
(R-HSA-5672863)
AKT1S1 [nucleoplasm]
(R-HSA-5083637)
p-T246-AKT1S1 [cytosol]
(R-HSA-377124)
p-S183,T246-AKT1S1 [cytosol]
(R-HSA-200163)
AKT1S1 [cytosol]
(R-HSA-200155)
0.564
2
UniProt:Q12933 TRAF2
5
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.536
2
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.525
2
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