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p-T37,T46-EIF4EBP1 [cytosol]
Stable Identifier
R-HSA-165685
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
4E-BP1-P
Locations in the PathwayBrowser for interactor UniProt:P06730%20EIF4E
Expand all
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
mTORC1-mediated signalling (Homo sapiens)
Dissociation of phosphorylated 4EBP1 from eIF4E (Homo sapiens)
p-T37,T46-EIF4EBP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13541 EIF4EBP1
Gene Names
EIF4EBP1
Chain
initiator methionine:, chain:2-118
Reference Genes
BioGPS Gene:1978 EIF4EBP1
COSMIC (genes):EIF4EBP1 EIF4EBP1
CTD Gene:1978 EIF4EBP1
dbSNP Gene:1978 EIF4EBP1
ENSEMBL:ENSG00000187840 EIF4EBP1
ENSEMBL_homo_sapiens_GENE:ENSG00000187840.5 EIF4EBP1
HGNC:3288 EIF4EBP1
KEGG Gene (Homo sapiens):1978 EIF4EBP1
Monarch:1978 EIF4EBP1
NCBI Gene:1978 EIF4EBP1
OMIM:602223 EIF4EBP1
UCSC:Q13541 EIF4EBP1
Reference Transcript
RefSeq:NM_004095.3 EIF4EBP1
Other Identifiers
11718283_a_at
11718284_x_at
11763248_x_at
17067963
1978
221539_PM_at
221539_at
31597_r_at
4049863
4049864
4049865
4049875
4049876
54152_at
8145889
A_23_P22224
GE79604
GE87606
GO:0000082
GO:0000278
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006417
GO:0008190
GO:0017148
GO:0023052
GO:0030371
GO:0031369
GO:0031929
GO:0043226
GO:0045182
GO:0045931
GO:0045947
HMNXSV003013289
ILMN_1767324
PH_hs_0028337
TC08000281.hg
g11527778_3p_at
Participates
as an output of
Dissociation of phosphorylated 4EBP1 from eIF4E (Homo sapiens)
as a component of
eIF4E:4E-BP1-P [cytosol] (Homo sapiens)
Other forms of this molecule
EIF4EBP1 [cytosol]
Inferred To
phospho-EIF4EBP1 [cytosol]
(Bos taurus)
phospho-EIF4EBP1 [cytosol]
(Canis familiaris)
phospho-EIF4EBP1 [cytosol]
(Sus scrofa)
phospho-Eif4ebp1 [cytosol]
(Mus musculus)
phospho-Eif4ebp1 [cytosol]
(Rattus norvegicus)
phospho-febA [cytosol]
(Dictyostelium discoideum)
phospho-p-T37,T46-EIF4EBP1 [cytosol]
(Gallus gallus)
phospho-wu:fc04h09 [cytosol]
(Danio rerio)
phospho-Thor [cytosol]
(Drosophila melanogaster)
Modified Residues
Name
O-phospho-L-threonine at 37
Coordinate
37
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 46
Coordinate
46
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_004086.1
OpenTargets
ENSG00000187840
HPA
ENSG00000187840-EIF4EBP1
GeneCards
Q13541
Ensembl
ENST00000338825
,
ENSG00000187840
,
ENSP00000340691
PRO
Q13541
Pharos - Targets
Q13541
PDB
6BCU
,
4UED
,
3M93
,
5NVN
,
1EJ4
,
1WKW
,
6BCX
,
3M94
,
3HXG
,
5WBJ
,
2V8W
,
5EKV
,
2JGB
,
3HXI
,
2V8X
,
2JGC
,
5BXV
,
2V8Y
,
3U7X
,
1EJH
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06730 EIF4E
1
EIF4E [cytosol]
(R-HSA-72578)
0.98
31
UniProt:Q8N122 RPTOR
3
RPTOR [nucleoplasm]
(R-HSA-5083664)
RPTOR [cytosol]
(R-HSA-3006727)
p-S722,S792-RPTOR [cytosol]
(R-HSA-3132767)
0.711
5
UniProt:O60573-1 EIF4E2
0.669
6
UniProt:P06730-1 EIF4E
0.591
3
UniProt:P15884 TCF4
1
TCF4 [nucleoplasm]
(R-HSA-445672)
0.556
3
IntAct:EBI-22653406 CCSB ORF ID
0.556
5
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.556
3
UniProt:Q04864-2 REL
0.556
3
UniProt:P25791-3 LMO2
0.556
3
UniProt:A6NMX2 I4E1B
0.556
3
UniProt:Q96D03 DDT4L
0.556
3
UniProt:P78424 PO6F2
0.556
3
UniProt:P50221 MEOX1
0.556
3
UniProt:Q8N720 ZNF655
1
ZNF655 [nucleoplasm]
(R-HSA-2127575)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
ChEBI:50210 7-METHYL-GTP
0.527
3
UniProt:Q9JLN9
2
MTOR [nucleoplasm]
(R-MMU-5083674)
MTOR [cytosol]
(R-MMU-165662)
0.525
2
UniProt:Q9UKV8 AGO2
2
AGO2 [nucleoplasm]
(R-HSA-5578701)
AGO2 [cytosol]
(R-HSA-209723)
0.524
2
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