Phosphorylation of 4E-BP1 by activated mTORC1

Stable Identifier
R-HSA-165692
Type
Reaction
Species
Homo sapiens
Compartment
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Raptor recruits mTOR to non-phosphorylated 4E-BP1 bound to eIF4E and positively modulates phosphorylation of 4E-BP1 by mTOR. 4E-BP1 is further phosphorylated on multiple sites by other unknown kinases, also contributing to the dissociation of 4E-BP1 from eIF4E. Thus mTORC1 relieves the inhibitory effect of 4E-BP1 on eIF4E dependent translation initiation (Inoki et al. 2005, Gingras et al. 1999, 2001).

Literature References
PubMed ID Title Journal Year
12150926 Raptor, a binding partner of target of rapamycin (TOR), mediates TOR

Hara, K, Maruki, Y, Long, X, Yoshino, K, Oshiro, N, Hidayat, S, Tokunaga, C, Avruch, J, Yonezawa, K

Cell 2002
15809305 Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR

Ali, SM, Sabatini, DM

J Biol Chem 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Active mTORC1 complex [lysosomal membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
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