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RPS6KB1 [cytosol]
Stable Identifier
R-HSA-165716
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
S6K1
Locations in the PathwayBrowser for interactor UniProt:P31749 AKT1
Expand all
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
mTORC1-mediated signalling (Homo sapiens)
mTORC1 phosphorylation of RPS6KB1 (S6K) (Homo sapiens)
RPS6KB1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23443 RPS6KB1
Gene Names
RPS6KB1, STK14A
Chain
chain:1-525
Reference Genes
BioGPS Gene:6198 RPS6KB1
COSMIC (genes):RPS6KB1 RPS6KB1
CTD Gene:6198 RPS6KB1
dbSNP Gene:6198 RPS6KB1
ENSEMBL:ENSG00000108443 RPS6KB1
HGNC:10436 RPS6KB1
KEGG Gene (Homo sapiens):6198 RPS6KB1
Monarch:6198 RPS6KB1
NCBI Gene:6198 RPS6KB1
OMIM:608938 RPS6KB1
UCSC:P23443 RPS6KB1
Reference Transcript
RefSeq:NM_001272043.1 RPS6KB1
RefSeq:NM_001272044.1 RPS6KB1
RefSeq:NM_003161.3 RPS6KB1
RefSeq:NM_001272060.1 RPS6KB1
RefSeq:NM_001272042.1 RPS6KB1
Other Identifiers
11723299_a_at
11723300_at
11723301_s_at
11747836_a_at
11750648_x_at
11752465_a_at
11752466_s_at
16836626
17121602
17121812
2037_s_at
204171_at
211578_s_at
226660_at
3714522
3714523
3714529
3714531
3714533
3714537
3714539
3714543
3714545
3714549
3714551
3719610
3729295
3729296
3729297
3729298
3729300
3729305
3729306
3729307
3729311
3729312
3729318
3729320
3729321
3729324
3729327
3729329
3729332
3729334
3729335
3729336
3729337
3729338
3729339
3729340
3729341
3729342
3729343
3754090
3754150
3754153
3765831
3765833
3765834
3765836
3765837
3765841
3765842
37946_at
4040904
4040948
6198
8008887
82929_at
90022_at
A_14_P119384
A_21_P0011601
A_23_P141329
A_24_P387179
A_24_P497226
GE58003
GO:0000082
GO:0000166
GO:0000278
GO:0003674
GO:0004672
GO:0004674
GO:0004711
GO:0004712
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005741
GO:0005829
GO:0006412
GO:0006417
GO:0006464
GO:0006468
GO:0006810
GO:0006915
GO:0007049
GO:0007165
GO:0008150
GO:0008219
GO:0009058
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0030054
GO:0031667
GO:0031929
GO:0032869
GO:0034641
GO:0043005
GO:0043066
GO:0043167
GO:0043226
GO:0044539
GO:0045202
GO:0045727
GO:0045931
GO:0045948
GO:0046627
GO:0048015
GO:0071363
GO:0106310
GO:0106311
HMNXSV003030273
HMNXSV003045873
HMNXSV003049476
Hs.146217.0.S1_3p_at
ILMN_1704557
PH_hs_0036671
TC17000729.hg
TC17002113.hg
TC17002739.hg
g189509_3p_a_at
g4506736_3p_at
Participates
as an input of
mTORC1 phosphorylation of RPS6KB1 (S6K) (Homo sapiens)
Other forms of this molecule
p-S371,T389-RPS6KB1 [cytosol]
Inferred To
psk1 [cytosol]
(Schizosaccharomyces pombe)
S6k [cytosol]
(Drosophila melanogaster)
rsks-1 [cytosol]
(Caenorhabditis elegans)
Rps6kb1 [cytosol]
(Mus musculus)
Rps6kb1 [cytosol]
(Rattus norvegicus)
YPK3 [cytosol]
(Saccharomyces cerevisiae)
pkgC [cytosol]
(Dictyostelium discoideum)
RPS6KB1 [cytosol]
(Bos taurus)
RPS6KB1 [cytosol]
(Canis familiaris)
RPS6KB1 [cytosol]
(Gallus gallus)
RPS6KB1 [cytosol]
(Sus scrofa)
RPS6KB1 [cytosol]
(Xenopus tropicalis)
rps6kb1b [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_003152.1
,
NP_001258973.1
,
NP_001258972.1
,
NP_001258971.1
,
NP_001258989.1
ZINC - World Drugs
KS6B1_HUMAN
Guide to Pharmacology - Targets
1525
OpenTargets
ENSG00000108443
ZINC - FDA approved
KS6B1_HUMAN
ZINC - Substances
KS6B1_HUMAN
ZINC - Biogenic
KS6B1_HUMAN
ZINC target
P23443
PRO
P23443
PDB
3WF7
,
5WBK
,
4L42
,
4L3J
,
4L44
,
3WF8
,
4L43
,
4RLO
,
3WE4
,
3WF5
,
4L45
,
3A60
,
4L3L
,
3WF9
,
4RLP
,
3A61
,
5WBH
,
4L46
,
3WF6
,
3A62
ZINC - Investigational
KS6B1_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000108443-RPS6KB1
GeneCards
P23443
Ensembl
ENST00000225577
,
ENST00000443572
,
ENST00000406116
,
ENST00000393021
,
ENSP00000225577
,
ENSP00000384335
,
ENSP00000376744
,
ENSG00000108443
,
ENSP00000441993
Pharos - Targets
P23443
ZINC - Predictions - Purchasable
KS6B1_HUMAN
HMDB Protein
HMDBP01426
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P55884 EIF3B
1
EIF3B [cytosol]
(R-HSA-72542)
0.564
3
UniProt:P13051-2 UNG
0.556
3
UniProt:Q06481-5 APLP2
0.556
3
UniProt:Q13057 COASY
1
COASY [mitochondrial outer membrane]
(R-HSA-196735)
0.544
4
UniProt:P31749 AKT1
13
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.519
2
UniProt:Q00005 2ABB
0.499
2
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