Phosphorylation of Ribosomal protein S6 by activated S6K1

Stable Identifier
R-HSA-165726
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Once phosphorylated, S6K1-P phosphorylates and activates ribosomal protein S6 (rpS6), which in turn selectively increases the translation of 5'-TOP mRNAs. These mRNAs encode exclusively for components of the translation machinery (PMID 15809305).

Literature References
PubMed ID Title Journal Year
15809305 Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR

Ali, SM, Sabatini, DM

J Biol Chem 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S371,T389-RPS6KB1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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