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p-S1108,S1148,S1192-EIF4G1 [cytosol]
Stable Identifier
R-HSA-165762
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF4G-P
Icon
Locations in the PathwayBrowser for interactor UniProt:P06730 EIF4E
Expand all
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
mTORC1-mediated signalling (Homo sapiens)
Phosphorylation and activation of eIF4G by activated S6K1 (Homo sapiens)
p-S1108,S1148,S1192-EIF4G1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q04637 EIF4G1
Gene Names
EIF4G1, EIF4F, EIF4G, EIF4GI
Chain
initiator methionine:, chain:1-1599
Reference Genes
BioGPS Gene:1981 EIF4G1
COSMIC (genes):EIF4G1 EIF4G1
CTD Gene:1981 EIF4G1
dbSNP Gene:1981 EIF4G1
ENSEMBL:ENSG00000114867 EIF4G1
HGNC:3296 EIF4G1
KEGG Gene (Homo sapiens):1981 EIF4G1
Monarch:1981 EIF4G1
NCBI Gene:1981 EIF4G1
OMIM:600495 EIF4G1
UCSC:Q04637 EIF4G1
Reference Transcript
RefSeq:NM_182917.4 EIF4G1
RefSeq:NM_198242.2 EIF4G1
RefSeq:NM_198241.2 EIF4G1
RefSeq:NM_004953.4 EIF4G1
Other Identifiers
0000770164
0001190551
0005390035
11726566_a_at
11726567_a_at
11726568_x_at
1306_at
16948909
1981
208624_s_at
208625_3p_s_at
208625_s_at
2655689
2655690
2655691
2655692
2655693
2655695
2655696
2655697
2655698
2655699
2655700
2655701
2655702
2655704
2655705
2655706
2655707
2655708
2655709
2655711
2655712
2655713
2655714
2655715
2655716
2655717
2655718
2655719
2655720
2655721
2655722
2655723
2655725
2655727
2655728
2655729
2655730
2655731
2655732
2655733
2655734
2655735
2655737
2655738
2655739
2655741
2655743
2655745
2655747
2655750
2655751
2655752
2655753
2655754
2655756
32844_at
57332_r_at
69222_at
8084439
A_23_P218892
GE62301
GO:0000184
GO:0000278
GO:0001662
GO:0002191
GO:0003674
GO:0003723
GO:0003729
GO:0003743
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0005844
GO:0006412
GO:0006413
GO:0006417
GO:0006446
GO:0006464
GO:0006914
GO:0006950
GO:0007049
GO:0008135
GO:0008150
GO:0008190
GO:0008219
GO:0009056
GO:0009058
GO:0010494
GO:0010507
GO:0010801
GO:0010942
GO:0016020
GO:0016032
GO:0016281
GO:0022607
GO:0030154
GO:0030307
GO:0031369
GO:0031669
GO:0032270
GO:0032502
GO:0032991
GO:0033138
GO:0034330
GO:0034641
GO:0034645
GO:0034655
GO:0036493
GO:0040007
GO:0042592
GO:0042802
GO:0043167
GO:0043226
GO:0043488
GO:0044403
GO:0045666
GO:0048856
GO:0060090
GO:0060964
GO:0065003
GO:0080135
GO:0097009
GO:1900087
GO:1901215
GO:1905537
GO:1905606
GO:1905612
GO:1905618
GO:1905696
Hs.211568.1.A1_3p_a_at
ILMN_1657066
ILMN_1672902
ILMN_1678244
ILMN_1768470
ILMN_2370772
PH_hs_0030188
TC03001000.hg
TC03002693.hg
g3941723_3p_s_at
Participant Of
output
Phosphorylation and activation of eIF4G by activated S6K1
Other forms of this molecule
EIF4G1 [cytosol]
Inferred To
phospho-EIF4G1 [cytosol] (Canis familiaris)
phospho-eIF4G1 [cytosol] (Drosophila melanogaster)
phospho-Eif4g1 [cytosol] (Mus musculus)
phospho-Eif4g1 [cytosol] (Rattus norvegicus)
phospho-eif4g1a [cytosol] (Danio rerio)
Homologues of p-S1108,S1148,S1192-EIF4G1 [cytosol] (Drosophila melanogaster)
Homologues of p-S1108,S1148,S1192-EIF4G1 [cytosol] (Saccharomyces cerevisiae)
phospho-eIF4G2 [cytosol] (Drosophila melanogaster)
phospho-tif471 [cytosol] (Schizosaccharomyces pombe)
phospho-ifg-1 [cytosol] (Caenorhabditis elegans)
phospho-eif4g [cytosol] (Dictyostelium discoideum)
phospho-fndc3a [cytosol] (Xenopus tropicalis)
phospho-TIF4631 [cytosol] (Saccharomyces cerevisiae)
phospho-p-S1108,S1148,S1192-EIF4G1 [cytosol] (Gallus gallus)
phospho-p-S1108,S1148,S1192-EIF4G1 [cytosol] (Plasmodium falciparum)
phospho-p-S1108,S1148,S1192-EIF4G1 [cytosol] (Sus scrofa)
phospho-TIF4632 [cytosol] (Saccharomyces cerevisiae)
Modified Residues
Name
O-phospho-L-serine at 1108
Coordinate
1108
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1148
Coordinate
1148
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1192
Coordinate
1192
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_004944.3
,
NP_937884.1
,
NP_937885.1
,
NP_886553.3
OpenTargets
ENSG00000114867
GeneCards
Q04637
HPA
ENSG00000114867-EIF4G1
Ensembl
ENSP00000371767
,
ENSP00000343450
,
ENSP00000316879
,
ENSP00000317600
,
ENST00000342981
,
ENST00000350481
,
ENSP00000338020
,
ENST00000424196
,
ENSP00000416255
,
ENST00000435046
,
ENST00000382330
,
ENST00000392537
,
ENST00000346169
,
ENST00000414031
,
ENST00000434061
,
ENSP00000411826
,
ENST00000352767
,
ENSG00000114867
,
ENSP00000404754
,
ENSP00000391935
,
ENSP00000376320
PRO
Q04637
Orphanet
20634
PDB
5T46
,
4F02
,
5EI3
,
1UG3
,
4AZA
,
2W97
,
1LJ2
,
5EIR
,
5EHC
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60842 EIF4A1
1
EIF4A1 [cytosol]
(R-HSA-72573)
0.961
15
UniProt:P06730 EIF4E
1
EIF4E [cytosol]
(R-HSA-72578)
0.915
10
UniProt:P11940 PABPC1
1
PABPC1 [cytosol]
(R-HSA-156803)
0.835
6
UniProt:Q14240 EIF4A2
1
EIF4A2 [cytosol]
(R-HSA-72575)
0.656
4
UniProt:Q9BWF3-1 RBM4
0.591
4
UniProt:Q9UGR2 Z3H7B
0.567
3
UniProt:P23116
1
Eif3a [cytosol]
(R-MMU-72546)
0.564
2
UniProt:O00571 DDX3X
3
DDX3X [extracellular region]
(R-HSA-6806507)
DDX3X [ficolin-1-rich granule lumen]
(R-HSA-6801273)
DDX3X [secretory granule lumen]
(R-HSA-6801275)
0.557
3
UniProt:Q04637 EIF4G1
2
EIF4G1 [cytosol]
(R-HSA-72584)
p-S1108,S1148,S1192-EIF4G1 [cytosol]
(R-HSA-165762)
0.544
2
UniProt:P03372 ESR1
8
SUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.527
3
UniProt:O75822 EIF3J
1
EIF3J [cytosol]
(R-HSA-72534)
0.524
2
UniProt:Q9J0X9 Q9J0X9
0.499
3
UniProt:Q14103-4 HNRNPD
2
HNRNPD-4 [cytosol]
(R-HSA-450442)
Ub-HNRNPD-4 [cytosol]
(R-HSA-451232)
0.499
3
UniProt:Q13283 G3BP1
0.491
2
UniProt:Q00721 NSP3
0.482
2
UniProt:Q09161 NCBP1
2
NCBP1 [cytosol]
(R-HSA-162459)
NCBP1 [nucleoplasm]
(R-HSA-51469)
0.462
2
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