Reactome | Phosphorylation and activation of eIF4G by activated S6K1

Phosphorylation and activation of eIF4G by activated S6K1

Stable Identifier

R-HSA-165766

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Phosphorylation and activation of eIF4G by activated S6K1

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Phosphorylated S6K1 in turn phosphorylates eIF4G, a component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Serine residues 1108, 1148, 1192 of the EIF4G1 isoform in Raught et al. (2000) correspond to serine residues 1147, 1185, and 1231 of the UniProt reference sequence.

Literature References

PubMed ID	Title	Journal	Year
10654941	Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI Raught, B, Gingras, AC, Gygi, SP, Imataka, H, Morino, S, Gradi, A, Aebersold, R, Sonenberg, N	EMBO J	2000
15314020	Upstream and downstream of mTOR Hay, N, Sonenberg, N	Genes Dev	2004