Phosphorylation and activation of eIF4G by activated S6K1

Stable Identifier
R-HSA-165766
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Phosphorylated S6K1 in turn phosphorylates eIF4G, a component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Serine residues 1108, 1148, 1192 of the EIF4G1 isoform in Raught et al. (2000) correspond to serine residues 1147, 1185, and 1231 of the UniProt reference sequence.
Literature References
PubMed ID Title Journal Year
10654941 Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI

Sonenberg, N, Aebersold, R, Gradi, A, Raught, B, Gygi, SP, Imataka, H, Gingras, AC, Morino, S

EMBO J 2000
15314020 Upstream and downstream of mTOR

Hay, N, Sonenberg, N

Genes Dev 2004
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-T412-RPS6KB1 [cytosol]

Orthologous Events
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