Reactome | PPP2CA [cytosol]

PPP2CA [cytosol]

Stable Identifier

R-HSA-165971

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PP2A-catalytic subunit C alpha isoform

Locations in the PathwayBrowser for interactor UniProt:Q13362 PPP2R5C

Expand all

External Reference Information

External Reference

UniProt:P67775 PPP2CA

Gene Names

PPP2CA

Chain

chain:1-309

Reference Genes

BioGPS Gene:5515 PPP2CA

COSMIC (genes):PPP2CA PPP2CA

CTD Gene:5515 PPP2CA

dbSNP Gene:5515 PPP2CA

ENSEMBL:ENSG00000113575 PPP2CA

ENSEMBL_homo_sapiens_GENE:ENSG00000113575.12 PPP2CA

HGNC:9299 PPP2CA

KEGG Gene (Homo sapiens):5515 PPP2CA

Monarch:5515 PPP2CA

NCBI Gene:5515 PPP2CA

OMIM:176915 PPP2CA

UCSC:P67775 PPP2CA

Reference Transcript

RefSeq:NM_002715.2 PPP2CA

Other Identifiers

11715804_s_at

11715805_a_at

11758731_at

17000022

208652_PM_at

208652_at

235502_PM_at

235502_at

237_s_at

238719_PM_at

238719_at

2876044

2876045

2876047

2876048

2876049

2876050

2876051

2876052

2876053

2876054

2876055

2876056

2876058

2876060

2876061

2876062

2876066

2876067

2876075

2876076

2876077

2876078

33181_at

48243_at

54851_at

5515

8114158

A_23_P122041

GE57999

GO:0000159

GO:0000278

GO:0000775

GO:0000922

GO:0001932

GO:0002376

GO:0003824

GO:0004721

GO:0004722

GO:0004725

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005694

GO:0005737

GO:0005739

GO:0005829

GO:0005856

GO:0005886

GO:0005975

GO:0006091

GO:0006260

GO:0006275

GO:0006351

GO:0006355

GO:0006470

GO:0006629

GO:0006672

GO:0006915

GO:0007155

GO:0007498

GO:0008092

GO:0008380

GO:0010033

GO:0010288

GO:0010719

GO:0012501

GO:0015630

GO:0016020

GO:0016787

GO:0017018

GO:0019932

GO:0022414

GO:0023052

GO:0030111

GO:0030154

GO:0030155

GO:0030308

GO:0035970

GO:0036211

GO:0040008

GO:0042532

GO:0043029

GO:0043226

GO:0045121

GO:0045202

GO:0045595

GO:0046872

GO:0046982

GO:0048156

GO:0048856

GO:0050811

GO:0051321

GO:0051898

GO:0055086

GO:0065003

GO:0070062

GO:0070262

GO:0071902

GO:0140096

GO:1900227

GO:1901135

GO:1904526

GO:1904528

GO:1904539

GO:2000045

HMNXSV003012706

Hs.102243.0.A1_3p_at

Hs.102243.0.A1_3p_x_at

Hs.79204.0.S1_3p_at

ILMN_1722858

ILMN_2196097

M60483_rna1_s_at

PH_hs_0005098

TC05003406.hg

g12653262_3p_at

Participates

as an input of

PPP2CA and PPP2R1A,B bind PPP2R2A in p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin (Homo sapiens)

as a component of

as a member of

PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)

as a candidate of

PP2A-catalytic subunit C [cytosol] (Homo sapiens)

Other forms of this molecule

MeL-PPP2CA [nucleoplasm]

p-Y307-PPP2CA [cytosol]

PPP2CA [nucleoplasm]

Inferred To

PPP2CA [cytosol] (Bos taurus)

PPP2CA [cytosol] (Caenorhabditis elegans)

PPP2CA [cytosol] (Canis familiaris)

PPP2CA [cytosol] (Dictyostelium discoideum)

PPP2CA [cytosol] (Drosophila melanogaster)

PPP2CA [cytosol] (Gallus gallus)

PPP2CA [cytosol] (Mus musculus)

PPP2CA [cytosol] (Plasmodium falciparum)

PPP2CA [cytosol] (Rattus norvegicus)

PPP2CA [cytosol] (Saccharomyces cerevisiae)

PPP2CA [cytosol] (Schizosaccharomyces pombe)

PPP2CA [cytosol] (Sus scrofa)

ppp2caa [cytosol] (Danio rerio)

ppp2ca [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_002706.1

Guide to Pharmacology - Targets

3263

OpenTargets

ENSG00000113575

GeneCards

P67775

HPA

ENSG00000113575-PPP2CA

Ensembl

ENSP00000418447, ENSG00000113575, ENST00000481195

ZINC target

P67775

PRO

P67775

Pharos - Targets

P67775

HMDB Protein

HMDBP02514

PDB

7SOY, 2NYM, 3P71, 3C5W, 8TTB, 4I5N, 7PKS, 4LAC, 2NYL, 4I5L, 8RBX, 7CUN, 8SO0, 4NY3, 3DW8, 6NTS, 8TWE, 8U89, 2IE3, 2NPP, 4IYP, 8RBZ, 3K7V, 8RC4, 3K7W, 7YCX, 5W0W, 8UWB, 2IAE, 2IE4, 3FGA, 8TWI, 8U1X, 7K36

Interactors (113)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30153 PPP2R1A	2	PPP2R1A [nucleoplasm] (R-HSA-165968) PPP2R1A [cytosol] (R-HSA-165982)	0.984	50
UniProt:P78318 IGBP1			0.959	20
UniProt:Q13362 PPP2R5C	3	PPP2R5C [nucleoplasm] (R-HSA-3008946) p-S337-PPP2R5C [cytosol] (R-HSA-6811447) PPP2R5C [cytosol] (R-HSA-3008954)	0.934	11
UniProt:P30154 PPP2R1B	2	PPP2R1B [cytosol] (R-HSA-165980) PPP2R1B [nucleoplasm] (R-HSA-166000)	0.919	9
UniProt:P63151 PPP2R2A	2	PPP2R2A [nucleoplasm] (R-HSA-1564978) PPP2R2A [cytosol] (R-HSA-377253)	0.915	12
UniProt:Q15173 PPP2R5B	2	p-S368-PPP2R5B [cytosol] (R-HSA-6811453) PPP2R5B [cytosol] (R-HSA-535469)	0.908	8
UniProt:Q15172 PPP2R5A	2	p-S28-PPP2R5A [cytosol] (R-HSA-9836658) PPP2R5A [cytosol] (R-HSA-196235)	0.903	8
UniProt:Q5VSL9 STRP1			0.899	10
UniProt:Q9Y570 PPME1	1	PPME1 [nucleoplasm] (R-HSA-8857790)	0.877	9
UniProt:Q13136 PPFIA1	1	PPFIA1 [cytosol] (R-HSA-383377)	0.864	8
UniProt:Q14738 PPP2R5D	2	PPP2R5D [nucleoplasm] (R-HSA-3008956) PPP2R5D [cytosol] (R-HSA-3008950)	0.864	8
UniProt:Q16537 PPP2R5E	1	PPP2R5E [cytosol] (R-HSA-1638770)	0.855	7
UniProt:Q5FBB7 SGO1	1	SGOL1 [cytosol] (R-HSA-376227)	0.848	7
UniProt:Q66LE6 PPP2R2D	1	PPP2R2D [nucleoplasm] (R-HSA-2160962)	0.848	10
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.84	7
UniProt:Q13033 STRN3			0.831	9
UniProt:Q9Y3A3 PHOCN			0.823	9
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.788	5
UniProt:Q15645 PCH2			0.764	6
UniProt:Q9P2B4 CT2NL			0.758	6
UniProt:P78371 CCT2	3	CCT2 [extracellular region] (R-HSA-6806220) CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [cytosol] (R-HSA-390464)	0.758	5
UniProt:O75145 PPFIA3	1	PPFIA3 [cytosol] (R-HSA-383382)	0.758	5
UniProt:Q9NRL3 STRN4			0.758	5
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.758	5
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.756	4
UniProt:Q14BN4 SLMAP			0.745	5
UniProt:Q76MZ3 Ppp2r1a	2	Ppp2r1a [nucleoplasm] (R-MMU-165968) PP2A A subunit [cytosol] (R-MMU-206067)	0.743	4
UniProt:Q9BRV8 SIKE1	1	SIKE1 [cytosol] (R-HSA-916828)	0.725	5
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.725	4
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.725	4
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.725	4
UniProt:P50990 CCT8	5	CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894) CCT8 [extracellular region] (R-HSA-6806238) CCT8 [azurophil granule lumen] (R-HSA-6799369) CCT8 [cytosol] (R-HSA-390449)	0.725	4
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.725	4
UniProt:Q16204 CCDC6			0.725	4
UniProt:Q9Y2T4 2ABG			0.708	6
UniProt:P22830 FECH	1	FECH [mitochondrial inner membrane] (R-HSA-189441)	0.671	4
UniProt:Q96CB8 INTS12	1	INTS12 [nucleoplasm] (R-HSA-6807456)	0.643	3
UniProt:Q9NVR7 TBCC1			0.643	3
UniProt:Q9Y5P8 PPP2R3B	1	PPP2R3B [nucleoplasm] (R-HSA-3008955)	0.643	3
UniProt:Q9UL03 INTS6	1	INTS6 [nucleoplasm] (R-HSA-6807440)	0.643	3
UniProt:Q8TF05 PP4R1			0.643	3
UniProt:Q5THK1 PR14L			0.643	3
UniProt:Q13033-2 STRN3			0.643	4
UniProt:Q9P289 STK26	3	MST4(306-416) [cytosol] (R-HSA-351903) MST4(1-305) [cytosol] (R-HSA-351855) MST4 [cytosol] (R-HSA-351918)	0.643	4
UniProt:Q9NVK5 FGFR1OP2	2	FGFR1OP(1-132)-FGFR1(429-822) fusion [cytosol] (R-HSA-1606443) FGFR1OP(1-132)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838998)	0.643	4
UniProt:Q96HW7 INTS4	1	INTS4 [nucleoplasm] (R-HSA-6807462)	0.643	3
UniProt:O15169 AXIN1	11	AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) RibC-AXIN1 [cytosol] (R-HSA-3640841) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) AXIN1 [cytosol] (R-HSA-195249)	0.643	4
UniProt:Q06190 P2R3A			0.643	4
UniProt:O00506 STK25			0.643	3
UniProt:Q86XL3 ANKLE2	2	ANKLE2 [endoplasmic reticulum membrane] (R-HSA-2529000) Ac-K302-ANKLE2 [endoplasmic reticulum membrane] (R-HSA-9667946)	0.643	3
UniProt:Q9Y6E0 STK24	4	STK24(1-313) [nucleoplasm] (R-HSA-351944) STK24(314-443) [cytosol] (R-HSA-351898) STK24(1-313) [cytosol] (R-HSA-351892) STK24 [cytosol] (R-HSA-351829)	0.643	3
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.641	4
UniProt:O14920 IKBKB	3	IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506)	0.641	3
UniProt:Q61249 IGBP1			0.602	3
UniProt:P03129 VE7			0.602	3
UniProt:Q00005 2ABB			0.597	5
UniProt:Q14674 ESPL1	4	ESPL1(1-1506) [cytosol] (R-HSA-2467768) ESPL1(1507-1535) [cytosol] (R-HSA-2500272) ESPL1(1536-2120) [cytosol] (R-HSA-2467767) ESPL1 [cytosol] (R-HSA-1638167)	0.597	3
UniProt:Q969F8 KISS1R	1	KISS1R [plasma membrane] (R-HSA-388974)	0.593	3
UniProt:Q04206 RELA	7	MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S536-RELA [nucleoplasm] (R-HSA-9861499) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.591	6
UniProt:O75663 TIPRL			0.589	3
UniProt:Q562F6 SGO2	1	SGOL2 [cytosol] (R-HSA-376242)	0.564	2
UniProt:Q9UPQ4-2 Q9UPQ42			0.556	3
UniProt:Q5T6F2 UBAP2			0.556	3
IntAct:EBI-22384931 CCSB ORF ID			0.556	3
UniProt:Q16740 CLPP	1	CLPP [mitochondrial matrix] (R-HSA-9838002)	0.556	3
UniProt:Q08AM6 VAC14	3	VAC14 [Golgi membrane] (R-HSA-1806235) VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219)	0.556	3
UniProt:Q96JM7-2 L3MBTL3			0.556	3
UniProt:Q3SXR2 CC036			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P28749 RBL1	2	RBL1 [nucleoplasm] (R-HSA-389104) p-T369,S640,S964,S975-RBL1 [nucleoplasm] (R-HSA-1226085)	0.544	2
UniProt:Q08999 RBL2	2	RBL2 [nucleoplasm] (R-HSA-389102) p-T401,S672,S1035-RBL2 [nucleoplasm] (R-HSA-1226084)	0.544	2
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.544	2
UniProt:Q9NV88 INTS9	1	INTS9 [nucleoplasm] (R-HSA-6807424)	0.527	2
UniProt:Q9H0H0 INTS2	1	INTS2 [nucleoplasm] (R-HSA-6807448)	0.527	2
UniProt:Q9BWN1 PRR14			0.527	2
UniProt:Q77M19 Q77M19			0.527	2
UniProt:Q5TA45 CPSF3L	1	CPSF3L [nucleoplasm] (R-HSA-6807411)	0.527	2
UniProt:Q9NVR2 INTS10	1	INTS10 [nucleoplasm] (R-HSA-6807420)	0.527	2
UniProt:Q969G9 NKD1			0.527	2
UniProt:Q9NQX6 ZNF331	1	ZNF331 [nucleoplasm] (R-HSA-1247549)	0.527	3
UniProt:O95684 CEP43	3	FGFR1OP(2-163)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604533) FGFR1OP(2-163)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838994) FGFR1OP [cytosol] (R-HSA-380309)	0.527	2
UniProt:Q6ZMY9 ZNF517	1	ZNF517 [nucleoplasm] (R-HSA-1973869)	0.527	2
UniProt:O43638 FOXS1			0.527	2
UniProt:Q8IYG6 LRC56			0.527	2
UniProt:Q96SY0 VWA9	1	VWA9 [nucleoplasm] (R-HSA-6807412)	0.527	2
UniProt:Q9NVH2 INTS7	1	INTS7 [nucleoplasm] (R-HSA-6807401)	0.527	2
UniProt:Q12950 FOXD4			0.527	3
UniProt:Q9NUC0 SRTD4			0.527	3
UniProt:P42695 NCAPD3	3	p-T1415,S1419-NCAPD3 [nucleoplasm] (R-HSA-2294594) p-T1415-NCAPD3 [nucleoplasm] (R-HSA-2294587) NCAPD3 [nucleoplasm] (R-HSA-1629790)	0.527	2
UniProt:Q8NC26 ZNF114	1	ZNF114 [nucleoplasm] (R-HSA-975026)	0.527	2
UniProt:Q96H86 ZNF764	1	ZNF764 [nucleoplasm] (R-HSA-3343766)	0.527	2
UniProt:Q9BXL8 CDCA4			0.527	4
UniProt:Q92974 ARHGEF2	1	ARHGEF2 [cytosol] (R-HSA-195101)	0.527	2
UniProt:Q7Z398 ZNF550	1	ZNF550 [nucleoplasm] (R-HSA-1973896)	0.527	2
UniProt:Q6P9B9 INTS5	1	INTS5 [nucleoplasm] (R-HSA-6807418)	0.527	2
UniProt:O00755 WNT7A	9	WNT7A [extracellular region] (R-HSA-517404) N4GlycoAsn-PalmS WNT7A [extracellular exosome] (R-HSA-3781951) N4GlycoAsn-PalmS WNT7A [endocytic vesicle membrane] (R-HSA-3781961) WNT7A [endoplasmic reticulum lumen] (R-HSA-3238312) N4GlycoAsn-WNT7A [endoplasmic reticulum lumen] (R-HSA-3238249) N4GlycoAsn-PalmS WNT7A [endoplasmic reticulum lumen] (R-HSA-3238354) N4GlycoAsn-PalmS WNT7A [Golgi lumen] (R-HSA-3247778) N4GlycoAsn-PalmS WNT7A [extracellular region] (R-HSA-3247774) N4GlycoAsn-PalmS WNT7A [plasma membrane] (R-HSA-3247833)	0.527	2
UniProt:O60293 ZC3H1			0.527	2
UniProt:Q9Y228 T3JAM			0.527	3
UniProt:Q9BUL8 PDC10			0.527	2
UniProt:Q75QN2 INTS8	1	INTS8 [nucleoplasm] (R-HSA-6807409)	0.527	2
UniProt:Q8N201 INTS1	1	INTS1 [nucleoplasm] (R-HSA-6807446)	0.527	2
UniProt:Q96E09 PBIR1			0.527	2
UniProt:Q8IYD2 KLD8A			0.527	2
UniProt:Q68E01 INTS3	1	INTS3 [nucleoplasm] (R-HSA-6807435)	0.527	2
UniProt:P62714 PPP2CB	4	MeL-PPP2CB [nucleoplasm] (R-HSA-8857799) p-Y307-PPP2CB [cytosol] (R-HSA-8857935) PPP2CB [nucleoplasm] (R-HSA-165991) PPP2CB [cytosol] (R-HSA-165987)	0.527	2
UniProt:P68104 EEF1A1	7	Me3K79-EEF1A1 [cytosol] (R-HSA-8932212) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) EEF1A1 [secretory granule lumen] (R-HSA-6801479) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [lysosomal membrane] (R-HSA-9626022)	0.527	3
UniProt:P04020 VE7			0.524	2
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.524	2
UniProt:P97346 NXN			0.524	2
UniProt:P46695 IER3	1	IER3 [cytosol] (R-HSA-6811515)	0.524	2
UniProt:Q14653 IRF3	6	p-5S,T404-IRF3 [nucleoplasm] (R-HSA-936418) p-4S,T404-IRF3 [nucleoplasm] (R-HSA-177654) p-4S,T404-IRF3 [cytosol] (R-HSA-166258) IRF3(272-427) [cytosol] (R-HSA-9729737) IRF3(2-271) [cytosol] (R-HSA-9729696) IRF3 [cytosol] (R-HSA-166251)	0.499	4
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.488	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.462	2

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