Reactome | PPP2CB [nucleoplasm]

PPP2CB [nucleoplasm]

Stable Identifier

R-HSA-165991

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PP2A-catalytic subunit C beta isoform

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        CCNG1 recruits PP2A-PPP2R5C to MDM2 (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
        
        PPP2CB [nucleoplasm] (Homo sapiens)
        
        PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
        
        PPP2CB [nucleoplasm] (Homo sapiens)
        
        PP2A-PP2R5C dephosphorylates MDM2 (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
        
        PPP2CB [nucleoplasm] (Homo sapiens)
        
        PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
        
        PPP2CB [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62714 PPP2CB

Gene Names

PPP2CB

Chain

chain:1-309

Reference Genes

BioGPS Gene:5516 PPP2CB

COSMIC (genes):PPP2CB PPP2CB

CTD Gene:5516 PPP2CB

dbSNP Gene:5516 PPP2CB

ENSEMBL:ENSG00000104695 PPP2CB

HGNC:9300 PPP2CB

KEGG:hsa:5516 PPP2CB

Monarch:5516 PPP2CB

NCBI Gene:5516 PPP2CB

OMIM:176916 PPP2CB

UCSC:P62714 PPP2CB

Reference Transcript

RefSeq:NM_001009552.1 PPP2CB

Other Identifiers

11716041_a_at

11716042_x_at

11726558_a_at

17076083

201374_3p_x_at

201374_PM_x_at

201374_x_at

201375_PM_s_at

201375_s_at

3130214

3130216

3130217

3130218

3130219

3130220

3130222

3130223

3130224

3130225

3130226

3130227

3130228

3130229

3130233

3130234

3130235

3130239

3130240

3130241

3130242

3130243

5516

8150126

924_s_at

A_23_P134693

GE58000

GE79502

GO:0000159

GO:0000278

GO:0000775

GO:0000922

GO:0003824

GO:0004721

GO:0004722

GO:0005515

GO:0005634

GO:0005694

GO:0005737

GO:0005829

GO:0005856

GO:0006355

GO:0006470

GO:0007005

GO:0008092

GO:0008637

GO:0010288

GO:0010468

GO:0010629

GO:0010804

GO:0016787

GO:0017018

GO:0030163

GO:0032088

GO:0034976

GO:0035970

GO:0042542

GO:0043161

GO:0043226

GO:0044325

GO:0046580

GO:0046677

GO:0046872

GO:0048156

GO:0070262

GO:0090443

GO:0140096

GO:1904528

HMNXSV003036743

Hs.80350.0.S1_3p_at

Hs.80350.0.S1_3p_x_at

ILMN_1675693

ILMN_1712659

ILMN_1768582

J03805_s_at

PH_hs_0027708

TC08001111.hg

g4758951_3p_a_at

Participates

as a candidate of

PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)

Other forms of this molecule

MeL-PPP2CB [nucleoplasm]

p-Y307-PPP2CB [cytosol]

PPP2CB [cytosol]

Inferred To

ppp2cb [nucleoplasm] (Danio rerio)

ppp2cb [nucleoplasm] (Xenopus tropicalis)

PPP2CA [nucleoplasm] (Caenorhabditis elegans)

PPP2CA [nucleoplasm] (Dictyostelium discoideum)

PPP2CA [nucleoplasm] (Drosophila melanogaster)

PPP2CA [nucleoplasm] (Saccharomyces cerevisiae)

PPP2CA [nucleoplasm] (Schizosaccharomyces pombe)

PPP2CB [nucleoplasm] (Bos taurus)

PPP2CB [nucleoplasm] (Canis familiaris)

PPP2CB [nucleoplasm] (Gallus gallus)

PPP2CB [nucleoplasm] (Mus musculus)

PPP2CB [nucleoplasm] (Rattus norvegicus)

PPP2CB [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001009552.1

ENSEMBL

ENST00000221138, ENSP00000221138

OpenTargets

ENSG00000104695

HPA

ENSG00000104695-PPP2CB

PRO

P62714

Pharos - Targets

P62714

GlyGen

P62714

HMDB Protein

HMDBP08685

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63151 PPP2R2A	2	PPP2R2A [nucleoplasm] (R-HSA-1564978) PPP2R2A [cytosol] (R-HSA-377253)	0.886	8
UniProt:Q9Y570 PPME1	1	PPME1 [nucleoplasm] (R-HSA-8857790)	0.788	6
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.788	6
UniProt:Q86XL3 ANKLE2	2	Ac-K302-ANKLE2 [endoplasmic reticulum membrane] (R-HSA-9667946) ANKLE2 [endoplasmic reticulum membrane] (R-HSA-2529000)	0.725	5
UniProt:Q9Y6E0 STK24	4	STK24 [cytosol] (R-HSA-351829) STK24(1-313) [cytosol] (R-HSA-351892) STK24(314-443) [cytosol] (R-HSA-351898) STK24(1-313) [nucleoplasm] (R-HSA-351944)	0.669	3
UniProt:Q9Y2T1 AXIN2	4	AXIN2 [cytosol] (R-HSA-3640821) ub-AXIN2 [cytosol] (R-HSA-4641131) RibC-AXIN2 [cytosol] (R-HSA-3640842) Ub-RibC-AXIN2 [cytosol] (R-HSA-3640859)	0.645	4
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.643	3
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.527	2
UniProt:Q9P289 STK26	3	MST4(306-416) [cytosol] (R-HSA-351903) MST4(1-305) [cytosol] (R-HSA-351855) MST4 [cytosol] (R-HSA-351918)	0.527	2
UniProt:Q9BRV8 SIKE1	1	SIKE1 [cytosol] (R-HSA-916828)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	11

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