Reactome | PPP2R1B [nucleoplasm]

PPP2R1B [nucleoplasm]

Stable Identifier

R-HSA-166000

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PP2A-subunit A beta isoform

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        CCNG1 recruits PP2A-PPP2R5C to MDM2 (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-subunit A [nucleoplasm] (Homo sapiens)
        
        PPP2R1B [nucleoplasm] (Homo sapiens)
        
        PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-subunit A [nucleoplasm] (Homo sapiens)
        
        PPP2R1B [nucleoplasm] (Homo sapiens)
        
        PP2A-PP2R5C dephosphorylates MDM2 (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-subunit A [nucleoplasm] (Homo sapiens)
        
        PPP2R1B [nucleoplasm] (Homo sapiens)
        
        PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-subunit A [nucleoplasm] (Homo sapiens)
        
        PPP2R1B [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P30154 PPP2R1B

Gene Names

PPP2R1B

Chain

initiator methionine:1, chain:2-601

Reference Genes

BioGPS Gene:5519 PPP2R1B

COSMIC (genes):PPP2R1B PPP2R1B

CTD Gene:5519 PPP2R1B

dbSNP Gene:5519 PPP2R1B

ENSEMBL:ENSG00000137713 PPP2R1B

HGNC:9303 PPP2R1B

KEGG Gene (Homo sapiens):5519 PPP2R1B

Monarch:5519 PPP2R1B

NCBI Gene:5519 PPP2R1B

OMIM:603113 PPP2R1B

UCSC:P30154 PPP2R1B

Reference Transcript

Other Identifiers

0005550014

0005670707

0007040019

1093_at

1094_g_at

11731881_a_at

11733784_at

11733785_at

11747147_a_at

16744289

202883_s_at

202884_s_at

202885_s_at

202886_s_at

222351_at

3391030

3391031

3391037

3391038

3391039

3391040

3391041

3391042

3391043

3391046

3391048

3391049

3391052

3391055

3391056

3391057

3391059

3391060

3391063

3391066

3391067

3391069

3391070

3391071

3391072

41429_at

53816_i_at

54307_r_at

5519

56320_at

65331_at

65332_g_at

72441_at

7951614

A_23_P52793

A_24_P107291

A_24_P98762

GE80019

GO:0000159

GO:0003674

GO:0004722

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0006464

GO:0006470

GO:0007165

GO:0008150

GO:0008219

GO:0008287

GO:0016791

GO:0019888

GO:0030234

GO:0032991

GO:0043226

GO:0043666

GO:0045121

GO:0048856

GO:0060561

GO:0070062

GO:2001241

Hs.108705.0.S3_3p_a_at

Hs.168737.0.A1_3p_at

ILMN_1704656

ILMN_1709247

ILMN_1779841

M65254_at

PH_hs_0025221

TC11002284.hg

g11386166_3p_a_at

g11386166_3p_s_at

g11692008_3p_a_at

g189429_3p_a_at

Participant Of

hasCandidate

PP2A-subunit A [nucleoplasm]

Other forms of this molecule

PPP2R1B [cytosol]

Inferred To

paa-1 [nucleoplasm] (Caenorhabditis elegans)

pppA [nucleoplasm] (Dictyostelium discoideum)

Pp2A-29B [nucleoplasm] (Drosophila melanogaster)

PPP2R1B [nucleoplasm] (Canis familiaris)

PPP2R1B [nucleoplasm] (Xenopus tropicalis)

Ppp2r1b [nucleoplasm] (Mus musculus)

Ppp2r1b [nucleoplasm] (Rattus norvegicus)

paa1 [nucleoplasm] (Schizosaccharomyces pombe)

ppp2r1ba [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_859051.1, NP_859050.1, NP_001171034.1, NP_001171033.1, NP_002707.3

OpenTargets

ENSG00000137713

HPA

ENSG00000137713-PPP2R1B

GeneCards

P30154

Ensembl

ENSG00000137713, ENSP00000376775, ENSP00000410671, ENSP00000343317, ENSP00000311344, ENSP00000437193, ENST00000393055, ENST00000527614, ENST00000311129, ENST00000341980, ENST00000426998

PRO

P30154

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43815 STRN	3	STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) STRN [cytosol] (R-HSA-9037081) p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908)	0.643	3
UniProt:O08722 Unc5b	1	Unc5b [plasma membrane] (R-RNO-421655)	0.616	4
UniProt:Q9BRV8 SIKE1	1	SIKE1 [cytosol] (R-HSA-916828)	0.527	2
UniProt:Q9Y6E0 STK24	4	STK24(314-443) [cytosol] (R-HSA-351898) STK24(1-313) [nucleoplasm] (R-HSA-351944) STK24(1-313) [cytosol] (R-HSA-351892) STK24 [cytosol] (R-HSA-351829)	0.527	2
UniProt:O08785 Clock	2	p-S-Clock [nucleoplasm] (R-MMU-508670) Clock [cytosol] (R-MMU-508720)	0.508	2
UniProt:P11233 RALA	2	RALA [cytosol] (R-HSA-170988) GGC-RALA [cytoplasmic vesicle membrane] (R-HSA-1458479)	0.499	6

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