Transfer of LPS from LBP carrier to CD14

Stable Identifier
R-HSA-166020
Type
Pathway
Species
Homo sapiens
Compartment
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LBP delivers LPS from bacteria (or bacterial membrane fragments) to CD14 on the surfaces of phagocytes, where it is recognised by the MD2:TLR4 complex . Thus, LBP is an opsonin and CD14 is an opsonic receptor for complexes of LPS (or LPS-containing particles such as bacteria) and LBP. CD14 exists as two isoforms. CD14 can be either secreted into the extracellular compartment, or it can be anchored to the plasma membrane via its GPI module.

Literature References
PubMed ID Title Journal Year
9665271 LPS-binding proteins and receptors

Fenton, MJ, Golenbock, DT

J Leukoc Biol 1998
Participants
Participant Of
Orthologous Events
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Created