Reactome | 2xN4GlycoAsn-TLR4 [plasma membrane]

2xN4GlycoAsn-TLR4 [plasma membrane]

Stable Identifier

R-HSA-166045

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

TLR4

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Locations in the PathwayBrowser for interactor UniProt:O00206 TLR4

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Literature References

PubMed ID	Title	Journal	Year
11706042	MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor Ulevitch, RJ, da Silva Correia, J	J. Biol. Chem.	2002

External Reference Information

External Reference

UniProt:O00206 TLR4

Gene Names

TLR4

Chain

signal peptide:1-23, chain:24-839

Reference Genes

BioGPS Gene:7099 TLR4

COSMIC (genes):TLR4 TLR4

CTD Gene:7099 TLR4

dbSNP Gene:7099 TLR4

ENSEMBL:ENSG00000136869 TLR4

ENSEMBL_homo_sapiens_GENE:ENSG00000136869.16 TLR4

HGNC:11850 TLR4

KEGG Gene (Homo sapiens):7099 TLR4

Monarch:7099 TLR4

NCBI Gene:7099 TLR4

OMIM:603030 TLR4

UCSC:O00206 TLR4

Reference Transcript

Other Identifiers

11743196_a_at

11743197_at

11747518_a_at

1552798_PM_a_at

1552798_a_at

17088527

221060_PM_s_at

221060_s_at

224341_PM_x_at

224341_x_at

232068_PM_s_at

232068_s_at

240948_PM_at

240948_at

3186967

3186968

3186969

3186971

3186972

3186973

3186974

3186976

3186977

3186978

3186979

3186980

3186981

3186982

3186983

3186984

3186985

3186986

3186987

3186988

3186989

3186990

3186991

3186992

3186993

3186994

3186995

43219_at

7099

75770_at

76813_i_at

76817_r_at

8157524

A_14_P202106

A_23_P60306

A_24_P69538

A_24_P868313

A_32_P66881

GE470555

GE59576

GO:0001530

GO:0001540

GO:0001726

GO:0001875

GO:0001891

GO:0002218

GO:0002224

GO:0002246

GO:0002322

GO:0002376

GO:0002537

GO:0002730

GO:0002755

GO:0003824

GO:0004888

GO:0005102

GO:0005515

GO:0005737

GO:0005768

GO:0005769

GO:0005886

GO:0006351

GO:0006355

GO:0006809

GO:0006909

GO:0006954

GO:0006955

GO:0007165

GO:0007252

GO:0007254

GO:0008289

GO:0009617

GO:0009897

GO:0009986

GO:0010008

GO:0010467

GO:0010572

GO:0010628

GO:0012501

GO:0014002

GO:0014004

GO:0014911

GO:0016020

GO:0016046

GO:0016192

GO:0016787

GO:0022008

GO:0022600

GO:0023052

GO:0030154

GO:0030890

GO:0031410

GO:0031663

GO:0032496

GO:0032497

GO:0032689

GO:0032700

GO:0032707

GO:0032715

GO:0032720

GO:0032722

GO:0032727

GO:0032728

GO:0032729

GO:0032731

GO:0032732

GO:0032733

GO:0032735

GO:0032755

GO:0032757

GO:0032760

GO:0032874

GO:0034142

GO:0035666

GO:0036120

GO:0036211

GO:0038023

GO:0042060

GO:0042088

GO:0042100

GO:0042116

GO:0042742

GO:0042802

GO:0042995

GO:0043032

GO:0043123

GO:0043226

GO:0043235

GO:0043406

GO:0045087

GO:0045342

GO:0045348

GO:0045429

GO:0045671

GO:0045944

GO:0046330

GO:0046651

GO:0046696

GO:0046982

GO:0048471

GO:0048661

GO:0048856

GO:0048870

GO:0050135

GO:0050671

GO:0050727

GO:0050729

GO:0050829

GO:0051092

GO:0051403

GO:0051770

GO:0060089

GO:0060729

GO:0060907

GO:0061809

GO:0065003

GO:0070371

GO:0070373

GO:0070374

GO:0070427

GO:0070430

GO:0070431

GO:0070434

GO:0071222

GO:0071223

GO:0071260

GO:0071346

GO:0098542

GO:0120163

GO:0140052

GO:1900017

GO:1900227

GO:1901224

GO:1903428

GO:1903974

GO:1904466

GO:1904646

GO:2000343

GO:2001238

HMNXSV003033006

Hs.177864.0.A1_3p_at

Hs2.159239.2.S1_3p_s_at

ILMN_1706217

PH_hs_0030838

TC09000601.hg

TC09002219.hg

U93091_at

g2429102_3p_s_at

g4507532_3p_s_at

Participates

as a component of

as an input of

Hemes:LY96 activates TLR4 (Homo sapiens)

Other forms of this molecule

TLR4 [endosome membrane]

Inferred To

Tehao [plasma membrane] (Drosophila melanogaster)

MstProx [plasma membrane] (Drosophila melanogaster)

Tlr4 [plasma membrane] (Mus musculus)

Tlr4 [plasma membrane] (Rattus norvegicus)

Tl [plasma membrane] (Drosophila melanogaster)

Homologues of 2xN4GlycoAsn-TLR4 [plasma membrane] (Drosophila melanogaster)

Toll-9 [plasma membrane] (Drosophila melanogaster)

TLR4 [plasma membrane] (Bos taurus)

TLR4 [plasma membrane] (Canis familiaris)

TLR4 [plasma membrane] (Gallus gallus)

TLR4 [plasma membrane] (Sus scrofa)

Toll-4 [plasma membrane] (Drosophila melanogaster)

Modified Residues

Name

N4-glycosyl-L-asparagine at 526

Coordinate

526

PsiMod Name

N4-glycosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.

Name

N4-glycosyl-L-asparagine at 575

Coordinate

575

PsiMod Name

N4-glycosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.

Cross References

RefSeq

NP_612564.1, NP_003257.1, NP_612567.1

Guide to Pharmacology - Targets

1754

OpenTargets

ENSG00000136869

ZINC - Substances

TLR4_HUMAN

ZINC target

O00206

PRO

O00206

PDB

3FXI, 4G8A, 5NAM, 2Z65, 3UL8, 2Z62, 3UL9, 2Z66, 2Z63, 3ULA, 3UL7, 5NAO

ZINC - Investigational

TLR4_HUMAN

GeneCards

O00206

HPA

ENSG00000136869-TLR4

Ensembl

ENSP00000377997, ENST00000394487, ENSP00000363089, ENSG00000136869, ENST00000355622

Pharos - Targets

O00206

Orphanet

22161

ZINC - Predictions - Purchasable

TLR4_HUMAN

HMDB Protein

HMDBP02639

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P58753 TIRAP	2	TIRAP [cytosol] (R-HSA-166141) p-4Y-TIRAP [plasma membrane] (R-HSA-2201321)	0.807	6
UniProt:Q99836 MYD88	8	MyD88 R196C [cytosol] (R-HSA-5602329) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 E65del [cytosol] (R-HSA-5602598) MYD88 [endosome membrane] (R-HSA-975123) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-166059)	0.758	4
UniProt:Q9Y6Y9 LY96	3	LY96 [extracellular region] (R-HSA-9707658) LY96 [endosome membrane] (R-HSA-2201307) 2xN4GlycoAsn-LY96 [plasma membrane] (R-HSA-166047)	0.743	7
UniProt:O00206 TLR4	2	TLR4 [endosome membrane] (R-HSA-2201285) 2xN4GlycoAsn-TLR4 [plasma membrane] (R-HSA-166045)	0.692	3
UniProt:Q9NPH5 NOX4	2	NOX4 [plasma membrane] (R-HSA-5212694) NOX4 [endoplasmic reticulum membrane] (R-HSA-6807561)	0.683	4
UniProt:Q86XR7 TICAM2	3	MyrG-p-S16-TICAM2 [secretory granule membrane] (R-HSA-6804964) MyrG-p-S16-TICAM2 [plasma membrane] (R-HSA-166160) MyrG-p-S16-TICAM2 [endosome membrane] (R-HSA-2201336)	0.678	3
UniProt:P09429 HMGB1	5	HMGB1 [secretory granule lumen] (R-HSA-6803337) HMGB1 [ficolin-1-rich granule lumen] (R-HSA-6803291) HMGB1 [extracellular region] (R-HSA-879382) HMGB1 [nucleoplasm] (R-HSA-266221) HC23,45-HMGB1 [extracellular region] (R-HSA-6797422)	0.604	3
UniProt:P11226 MBL2	1	MBL2 [extracellular region] (R-HSA-166674)	0.558	2
UniProt:Q9Y336 SIGLEC9	2	SIGLEC9 [plasma membrane] (R-HSA-197723) SIGLEC9 [secretory granule membrane] (R-HSA-6804775)	0.544	2
UniProt:O15389 SIGLEC5	4	SIGLEC5 [ficolin-1-rich granule membrane] (R-HSA-6801283) SIGLEC5 [secretory granule membrane] (R-HSA-6801292) SIGLEC5 [plasma membrane] (R-HSA-197711) SIGLEC5 [tertiary granule membrane] (R-HSA-6801320)	0.544	2
UniProt:O43699-3 SIGLEC6			0.544	2
UniProt:Q9Y2C9 TLR6	1	TLR6 [plasma membrane] (R-HSA-168061)	0.499	2