Reactome | 2xN4GlycoAsn-TLR4 [plasma membrane]

2xN4GlycoAsn-TLR4 [plasma membrane]

Stable Identifier

R-HSA-166045

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

TLR4

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Locations in the PathwayBrowser for interactor UniProt:Q9Y2C9 TLR6

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Literature References

PubMed ID	Title	Journal	Year
11706042	MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor Ulevitch, RJ, da Silva Correia, J	J. Biol. Chem.	2002

External Reference Information

External Reference

UniProt:O00206 TLR4

Gene Names

TLR4

Chain

signal peptide:1-23, chain:24-839

Reference Genes

COSMIC (genes):TLR4 TLR4

dbSNP Gene:7099 TLR4

ENSEMBL:ENSG00000136869 TLR4

Participates

as a component of

as an input of

Hemes:LY96 activates TLR4 (Homo sapiens)

Other forms of this molecule

TLR4 [endosome membrane]

Inferred To

Tehao [plasma membrane] (Drosophila melanogaster)

MstProx [plasma membrane] (Drosophila melanogaster)

Tlr4 [plasma membrane] (Mus musculus)

Tlr4 [plasma membrane] (Rattus norvegicus)

Tl [plasma membrane] (Drosophila melanogaster)

Homologues of 2xN4GlycoAsn-TLR4 [plasma membrane] (Drosophila melanogaster)

Toll-9 [plasma membrane] (Drosophila melanogaster)

TLR4 [plasma membrane] (Bos taurus)

TLR4 [plasma membrane] (Canis familiaris)

TLR4 [plasma membrane] (Gallus gallus)

TLR4 [plasma membrane] (Sus scrofa)

Toll-4 [plasma membrane] (Drosophila melanogaster)

Modified Residues

Name

N4-glycosyl-L-asparagine at 526

Coordinate

526

PsiMod Name

N4-glycosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.

Name

N4-glycosyl-L-asparagine at 575

Coordinate

575

PsiMod Name

N4-glycosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P58753 TIRAP	2	TIRAP [cytosol] (R-HSA-166141) p-4Y-TIRAP [plasma membrane] (R-HSA-2201321)	0.807	6
UniProt:Q99836 MYD88	8	MyD88 R196C [cytosol] (R-HSA-5602329) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 E65del [cytosol] (R-HSA-5602598) MYD88 [endosome membrane] (R-HSA-975123) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-166059)	0.758	4
UniProt:Q9Y6Y9 LY96	3	LY96 [extracellular region] (R-HSA-9707658) LY96 [endosome membrane] (R-HSA-2201307) 2xN4GlycoAsn-LY96 [plasma membrane] (R-HSA-166047)	0.743	7
UniProt:O00206 TLR4	2	TLR4 [endosome membrane] (R-HSA-2201285) 2xN4GlycoAsn-TLR4 [plasma membrane] (R-HSA-166045)	0.692	3
UniProt:Q9NPH5 NOX4	2	NOX4 [endoplasmic reticulum membrane] (R-HSA-6807561) NOX4 [plasma membrane] (R-HSA-5212694)	0.683	4
UniProt:Q86XR7 TICAM2	3	MyrG-p-S16-TICAM2 [plasma membrane] (R-HSA-166160) MyrG-p-S16-TICAM2 [secretory granule membrane] (R-HSA-6804964) MyrG-p-S16-TICAM2 [endosome membrane] (R-HSA-2201336)	0.678	3
UniProt:P09429 HMGB1	5	HC23,45-HMGB1 [extracellular region] (R-HSA-6797422) HMGB1 [nucleoplasm] (R-HSA-266221) HMGB1 [extracellular region] (R-HSA-879382) HMGB1 [secretory granule lumen] (R-HSA-6803337) HMGB1 [ficolin-1-rich granule lumen] (R-HSA-6803291)	0.604	3
UniProt:P11226 MBL2	1	MBL2 [extracellular region] (R-HSA-166674)	0.558	2
UniProt:Q9Y336 SIGLEC9	2	SIGLEC9 [plasma membrane] (R-HSA-197723) SIGLEC9 [secretory granule membrane] (R-HSA-6804775)	0.544	2
UniProt:O15389 SIGLEC5	4	SIGLEC5 [tertiary granule membrane] (R-HSA-6801320) SIGLEC5 [secretory granule membrane] (R-HSA-6801292) SIGLEC5 [plasma membrane] (R-HSA-197711) SIGLEC5 [ficolin-1-rich granule membrane] (R-HSA-6801283)	0.544	2
UniProt:O43699-3 SIGLEC6			0.544	2
UniProt:Q9Y2C9 TLR6	1	TLR6 [plasma membrane] (R-HSA-168061)	0.499	2

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